Search results for "DIAGNOSTICS"
showing 10 items of 197 documents
Plasma diagnostic tools for ECR ion sources : What can we learn from these experiments for the next generation sources
2019
International audience; The order-of-magnitude performance leaps of ECR ion sources over the past decades result from improvements to the magnetic plasma confinement, increases in the microwave heating frequency, and techniques to stabilize the plasma at high densities. Parallel to the technical development of the ion sources themselves, significant effort has been directed into the development of their plasma diagnostic tools. We review the recent results of Electron Cyclotron Resonance Ion Source (ECRIS) plasma diagnostics highlighting a number of selected examples of plasma density, electron energy distribution, and ion confinement time measurements, obtained mostly with the second-gener…
Molecular diagnostics in gastric cancer.
2014
Despite recent advances in individualised targeted therapy, gastric cancer remains one of the most challenging diseases in gastrointestinal oncology. Modern imaging techniques using endoscopic filter devices and in vivo molecular imaging are designed to enable early detection of the cancer and surveillance of patients at risk. Molecular characterisation of the tumour itself as well as of the surrounding inflammatory environment is more sophisticated in the view of tailored therapies and individual prognostic assessment. The broad application of high throughput techniques for the description of genome wide patterns of structural (copy number aberrations, single nucleotide polymorphisms, meth…
Photoelectron Emission from Metal Surfaces Induced by Radiation Emitted by a 14 GHz Electron Cyclotron Resonance Ion Source
2015
Photoelectron emission measurements have been performed using a room-temperature 14 GHz ECR ion source. It is shown that the photoelectron emission from Al, Cu, and stainless steel (SAE 304) surfaces, which are common plasma chamber materials, is predominantly caused by radiation emitted from plasma with energies between 8 eV and 1 keV. Characteristic X-ray emission and bremsstrahlung from plasma have a negligible contribution to the photoelectron emission. It is estimated from the measured data that the maximum conceivable photoelectron flux from plasma chamber walls is on the order of 10% of the estimated total electron losses from the plasma. peerReviewed
Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers
2021
Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compared to those with normal immunoglobulin levels and, therefore, there is a rational explanation to administer intravenous IgM-enriched immunoglobulins to septic patients in ICU. Aim of this study is to evaluate the effectiveness of intravenous IgM-enriched immunoglobulins in decreasing several sepsis biomarker concentrations. 26 sepsis patients were enrolled in this observational cohort study and Nitric Oxide, Endocan, Pentraxin and presepsin serum levels were measured during their first 3 days of ICU stay. The use of intravenous IgM-enriched immunoglobulins did not influence the temporal evol…
Statistical issues in the development of an automotive on-board diagnostics
2008
The automotive on-board diagnostics (OBD) is a complex system whose aim is to monitor the state-of-health of another complex system, i.e. the vehicle engine. OBD aimed at the containment of polluting exhaust emissions is nowadays compulsory on every vehicle model introduced into the market. Increasingly stringent regulations and ever more demanding customers push from opposite sides towards a perfect working of OBD systems. Therefore manufacturers are globally interested in the high robustness and reliability of such critical systems. The aim of this presentation is to give an insight into the main statistical problems arisen during an extensive research project carried out in collaboration…
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
2006
Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis and glucose degradation to lactate. The nonoxidative part of the PPP is controlled by transketolase enzyme reactions. We have detected upregulation of a mutated transketolase transcript (TKTL1) in human malignancies, whereas transketolase (TKT) and transketolase-like-2 (TKTL2) transcripts were not upregulated. Strong TKTL1 protein expression was correlated to invasive colon and urothelial tumours and to poor patients outcome. TKTL1 encodes a transketolase with unusual enzymatic prop…
Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnos…
2021
Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment …
Diagnostic system based on the T.r.u.e. Methodology (Termography, Radar, Ultrasound, Endoscopy) and its applications
2013
Il poster 1 è dedicato alla Metodologia T.R.U.E., che persegue l'obiettivo di supportare la progettazione del restauro, con particolare riferimento alla conservazione delle superfici di finitura e nel rispetto del valore di autenticità materiale delle architetture storiche. Poster number 1 is dedicated to the T.R.U.E. Methodology, that pursues the finality to elaborate the project for the conservation of the architectural surfaces and, in general, the respect of the authenticity of the materials stratified on the monumental architectures.
Finte Pietre. Architettura dell'apparire e conservazione dei valori culturali
2012
Il volume presenta gli esiti di una ricerca incentrata sulla conoscenza delle finiture architettoniche di pietra artificiale, con particolare attenzione agli intonaci brevettati nel 1901 dai fratelli Li Vigni. Le attività di studio sono condotte attraverso la ricognizione dei documenti conservati presso l’Archivio Centrale dello Stato a Roma, e compiono una rigorosa selezione e analisi dei brevetti con l’obiettivo di tracciare il percorso evolutivo dei metodi d’intonacatura ed evidenziare i legami che s’instaurano tra le ricerche in corso nei diversi paesi. Nel XIX secolo i ricercatori di molte nazionalità avviano una selezione critica delle ricette tramandate dal passato e perfezionano pro…
The relationship between visible light emission and species fraction of the hydrogen ion beams extracted from 2.45 GHz microwave discharge.
2015
The relationship between Balmer-α and Fulcher-band emissions with extracted H + , H + 2 , and H + 3 ions is demonstrated for a 2.45 GHz microwave discharge. Ion mass spectra and optical measurements of Balmer-α and Fulcher-band emissions have been obtained with a Wien Filter having an optical viewport on the plasma chamber axis. The beam of approximately 1 mA is analyzed for different plasma conditions simultaneously with the measurement of light emissions both with temporal resolution. The use of visible light emissions as a valuable diagnostic tool for monitoring the species fraction of the extracted beams is proposed. peerReviewed