Search results for "DIAGNOSTICS"

“Ultra-sensitive” cardiac troponins: Requirements for effective implementation in clinical practice

2018

The measurement of cardiac troponins, either cardiac troponin I or T, has become the culprit of clinical decision making in patients with suspected acute coronary syndrome (ACS), especially in those with non-ST elevation myocardial infarction (NSTEMI). The leading analytical mainstays of cardiac troponin immunoassays include the limit of blank (LoB), limit of detection (LoD), functional sensitivity, the 99th percentile of a healthy reference population, along with the percentage of “ostensibly healthy” subjects displaying measurable values 50% in the general healthy population. The very recent commercialization of methods with further improved analytical sensitivity (i.e., “ultra-sensitive”…

Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy

2021

Abstract Background Brain tumor surgery must balance the benefit of maximal resection against the risk of inflicting severe damage. The impact of increased resection is diagnosis-specific. However, the precise diagnosis is typically uncertain at surgery due to limitations of imaging and intraoperative histomorphological methods. Novel and accurate strategies for brain tumor classification are necessary to support personalized intraoperative neurosurgical treatment decisions. Here, we describe a fast and cost-efficient workflow for intraoperative classification of brain tumors based on DNA methylation profiles generated by low coverage nanopore sequencing and machine learning algorithms. Met…

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

2021

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compared to those with normal immunoglobulin levels and, therefore, there is a rational explanation to administer intravenous IgM-enriched immunoglobulins to septic patients in ICU. Aim of this study is to evaluate the effectiveness of intravenous IgM-enriched immunoglobulins in decreasing several sepsis biomarker concentrations. 26 sepsis patients were enrolled in this observational cohort study and Nitric Oxide, Endocan, Pentraxin and presepsin serum levels were measured during their first 3 days of ICU stay. The use of intravenous IgM-enriched immunoglobulins did not influence the temporal evol…

Die Lungentuberkulose – aktuelle radiologische Diagnostik einer alten Krankheit

2000

Inzidenz. Abnehmende Inzidenzen aktiver Tuberkulose in den Industrielandern haben diese Erkrankung aus dem Bewusstsein vieler verdrangt. Dennoch stellt die Tuberkulose weiterhin weltweit die am haufigsten zum Tode fuhrende Infektionskrankheit dar. In den Industrielandern tragen Faktoren wie Einwanderungsbewegungen, zunehmende Verarmung und die Zunahme immunsupprimierter Patienten, insbesondere durch die HIV-Epidemie, dazu bei, dass ein Reservoir fur die Tuberkulose aufrecht erhalten wird. Diagnose. Eine fruhzeitige Diagnose ist wegen der spezifischen Therapiemoglichkeiten entscheidend fur den Krankheitsverlauf; im Falle von multiresistenten Stammen ist sie wichtig zur Verhinderung einer wei…

Radiation engineered nanogels as platform for next-generation of medical diagnostics and therapeutics

2010

Ion beam intensity and phase space measurement techniques for ion sources.

2022

Ion sources produce beams used in accelerators and other applications. Both development and use of ion sources need beam diagnostics to probe the plasma processes and beam formation for optimization purposes and to produce beam parameters needed for transport tuning. These diagnostics include beam intensity measurements usually carried out with Faraday cups or inductive pickups, magnetic separation, profile measurements with scintillation screens and wires, and phase space measurements with different types of emittance scanners. peerReviewed

Dynamic regimes of cyclotron instability in the afterglow mode of minimum-B electron cyclotron resonance ion source plasma

2016

The paper is concerned with the dynamic regimes of cyclotron instabilities in non-equilibrium plasma of a minimum-B electron cyclotron resonance ion source operated in pulsed mode. The instability appears in decaying ion source plasma shortly (1–10 ms) after switching off the microwave radiation of the klystron, and manifests itself in the form of powerful pulses of electromagnetic emission associated with precipitation of high-energy electrons along the magnetic field lines. Recently it was shown that this plasma instability causes perturbations of the extracted ion current, which limits the performance of the ion source and generates strong bursts of bremsstrahlung emission. In this artic…

Characteristic Kα emission of electron cyclotron resonance ion source plasmas

2018

This thesis presents the results of an investigation of the volumetric Kα emission rate/inner shell ionization rate from an Electron Cyclotron Resonance Ion Source (ECRIS) plasma tuned predominantly for high charge state ion production. The experimental work include four complimentary studies covering the influence of a parametric sweep of the four source tune parameters i.e microwave power, neutral gas flow, biased disc voltage and magnetic field on the volumetric Kα emission rate, an investigation into the gas mixing effect, an investigation into the effectiveness of double-frequency heating mode and finally an investigation into microwave induced electron losses (relative and direct) from th…

A novel approach to β-decay: PANDORA, a new experimental setup for future in-plasma measurements

2022

International audience; Theoretical predictions as well as experiments performed at storage rings have shown that the lifetimes of β-radionuclides can change significantly as a function of the ionization state. In this paper we describe an innovative approach, based on the use of a compact plasma trap to emulate selected stellar-like conditions. It has been proposed within the PANDORA project (Plasmas for Astrophysics, Nuclear Decay Observation and Radiation for Archaeometry) with the aim to measure, for the first time in plasma, nuclear β-decay rates of radionuclides involved in nuclear-astrophysics processes. To achieve this task, a compact magnetic plasma trap has been designed…

The relationship between visible light emission and species fraction of the hydrogen ion beams extracted from 2.45 GHz microwave discharge.

2015

The relationship between Balmer-α and Fulcher-band emissions with extracted H + , H + 2 , and H + 3 ions is demonstrated for a 2.45 GHz microwave discharge. Ion mass spectra and optical measurements of Balmer-α and Fulcher-band emissions have been obtained with a Wien Filter having an optical viewport on the plasma chamber axis. The beam of approximately 1 mA is analyzed for different plasma conditions simultaneously with the measurement of light emissions both with temporal resolution. The use of visible light emissions as a valuable diagnostic tool for monitoring the species fraction of the extracted beams is proposed. peerReviewed