Search results for "DIF"

showing 10 items of 16936 documents

Lämpöyhtälön ja Laplacen yhtälön ratkaisun ominaisuuksia

2015

Tämän tutkielman tarkoituksena on tutustua kahteen tärkeään osittaisdifferentiaaliyhtälöön; Laplacen yhtälöön ja lämpöyhtälöön. Näitä molempia hyödynnetään fysiikan lisäksi useiden muidenkin tieteenalojen sovelluksissa. Lämpöyhtälö, joka tunnetaan myös diffuusioyhtälönä, kuvaa jonkin suureen esimerkiksi lämmön johtumista aineissa ajan kuluessa. Pitkän ajan kuluttua tilanne tasapainottuu, jolloin lämmön määrä pysyy ajan suhteen vakiona tarkasteltavan alueen joka pisteessä. Tällaista täysin stabiloitunutta tilannetta voidaan mallintaa Laplacen yhtälöllä. Laplacen yhtälön toteuttavia funktioita kutsutaan harmonisiksi funktioiksi. Tutkielmassa johdetaan perusratkaisu ja keskiarvoperiaate molemm…

osittaisdifferentiaaliyhtälötyhtälöt
researchProduct

Adipogenic and osteogenic differentiation of mesenchymal stem cells.

2009

osteocytedifferentiationSettore BIO/06 - Anatomia Comparata E Citologiaadipocytemesenchymal stem cell
researchProduct

Uz hidroksiapatīta materiāliem audzētu cilvēka kaulu smazdzeņu mezenhimālo šūnu raksturošana

2020

Maģistra darba mērķis bija veikt cilvēka kaula smadzeņu mezenhimālās cilmes šūnu augšanu uz dažādu veidu hidroksiapatīta materiāliem un noteikt šūnu morfoloģiskās īpašības uz tiem. Lai sasniegtu izvirzīto mērķi, izmantojām šūnu iekrāsošanas metodes ar dažādām krāsvielām (faloidīnu, hoechst, Ki-67) un mikroskopā vērojām, kā šūnas uzvedas uz HA pārklājumiem. Morfoloģiskie dati tika analizēti ar NIS-elements un ImageJ programmām. Rezultāti parādīja, ka KS-MCŠ morfoloģija var ievērojami atšķirties audzētām uz dažādiem HA pārklājumiem.

osteodiferenciācijaMezenhimālās cilmes šūnasšūnu morfoloģijaFarmācijahidroksiapatīts
researchProduct

Sigma 1 receptora ietekme uz peļu mezenhimālo stromas šūnu osteodiferenciāciju

2021

Mezenhimālajām stromas šūnām (MSŠ) piemīt osteodiferenciācijas potenciāls. Sigma-1 receptors (SigmaR1) ir transmembrānu proteīns, tā ietekme uz osteodiferenciāciju nav vēl zināma. Bakalaura darba mērķis bija noskaidrot SigmaR1 ietekmi uz peļu taukaudu MSŠ (T-MSŠ) osteodiferenciāciju. Osteodiferenciācijas norise un SigmaR1 ietekme uz osteodiferenciāciju tika analizēta, pētot osteoģenēzē iesaistīto gēnu ekspresiju peļu T-MSŠ ar qPCR metodi. Salīdzinot izslēgta SigmaR1 (S1R-/-) T-MSŠ pret WT (wild type) T-MSŠ gēnu ekspresiju pēc osteodiferenciācijas, transkripcijas faktora osterix ekspresija tika nozīmīgi palielināta, bet nediferencētā stāvoklī būtiskas izmaiņas netika novērotas.

osteodiferenciācijaSigma-1 receptorsFarmācijastromālā vaskulārā frakcijagēnu ekspresijamezenhimālās stromas šūnas
researchProduct

Oxidation of aromatic alcohols in irradiated aqueous suspensions of commercial and home-prepared rutile TiO(2): a selectivity study.

2008

WOS: 000256241700021

oxidationPhotochemistryUltraviolet RaysAlcoholAnisolesAldehydeAlcohols Oxidation Photocatalysis Rutile SelectivityCatalysisCatalysisalcoholschemistry.chemical_compoundX-Ray DiffractionOrganic chemistryReactivity (chemistry)chemistry.chemical_classificationTitaniumSettore ING-IND/24 - Principi Di Ingegneria ChimicaAqueous solutionalcohols;oxidation;photocatalysis;rutile;selectivityMolecular StructureOrganic ChemistryselectivityWaterGeneral ChemistrychemistryBenzyl alcoholPhotocatalysisSettore CHIM/07 - Fondamenti Chimici Delle TecnologieSelectivityrutilephotocatalysisOxidation-ReductionBenzyl AlcoholChemistry (Weinheim an der Bergstrasse, Germany)
researchProduct

Variational parabolic capacity

2015

We establish a variational parabolic capacity in a context of degenerate parabolic equations of $p$-Laplace type, and show that this capacity is equivalent to the nonlinear parabolic capacity. As an application, we estimate the capacities of several explicit sets.

p-parabolic equationcapacityApplied Mathematicsta111Mathematical analysisDegenerate energy levelsMathematics::Analysis of PDEsContext (language use)Parabolic cylinder functionType (model theory)Parabolic partial differential equationHeat capacityNonlinear systemdegenerate parabolic equationsnonlinear potential theoryDiscrete Mathematics and CombinatoricsAnalysisComputer Science::Information TheoryMathematicsDiscrete and Continuous Dynamical Systems
researchProduct

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

2017

Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…

p530301 basic medicineCancer ResearchSmall interfering RNAMethyltransferaseCellular differentiationDruggabilityBiologyArticleEpigenesis GeneticNeuroblastoma03 medical and health sciences0302 clinical medicineNeuroblastomamedicineHumansEpigeneticsRNA Small InterferingGeneCell ProliferationsiRNA screenCell growthQuinazolineCell DifferentiationdifferentiationHistone-Lysine N-Methyltransferasemedicine.diseaseSETD8030104 developmental biologyOncology030220 oncology & carcinogenesisQuinazolinesCancer researchdifferentiation; epigenetics; neuroblastoma; p53; SETD8; siRNA screen; Oncology; Cell Biology; Cancer ResearchTumor Suppressor Protein p53epigeneticHuman
researchProduct

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

2010

10 p.-5 fig.

p53Cancer ResearchGenotypeCellular differentiationImmunologyPopulationp73RegulatorBiologyCellular and Molecular NeuroscienceMiceNeurosphereAnimalsProgenitor celleducationCell ProliferationNeuronsNeural stem cellseducation.field_of_studyCell growthTumor Suppressor ProteinsNuclear ProteinsCell DifferentiationNeurodegenerative DiseasesTumor Protein p73Cell BiologyEmbryonic stem cellasymmetric divisionNeural stem cellCell biologyDNA-Binding ProteinsDifferentiationSelf-renewalOriginal ArticleTumor Suppressor Protein p53
researchProduct

"Table 6" of "$\rm{K}^{*}(\rm{892})^{0}$ and $\phi(1020)$ production at midrapidity in pp collisions at $\sqrt{s}$ = 8 TeV"

2020

No table description available.

pT differential ratio 7TeV to 2.76TeV for Kstar1/Nev d^2N/(dp_Tdy) (GeV/c)^{-1}7000.0-8000.0
researchProduct

"Table 8" of "$\rm{K}^{*}(\rm{892})^{0}$ and $\phi(1020)$ production at midrapidity in pp collisions at $\sqrt{s}$ = 8 TeV"

2020

No table description available.

pT differential ratio 7TeV to 2.76TeV for Phi1/Nev d^2N/(dp_Tdy) (GeV/c)^{-1}7000.0-8000.0
researchProduct