Search results for "DILI"
showing 10 items of 427 documents
Detection of a synthetic sex steroid in the American crocodile (Crocodylus acutus): Evidence for a novel environmental androgen
2017
Endocrine-disrupting contaminants (EDC's) are well known to alter sexual differentiation among vertebrates via estrogenic effects during development, particularly in organisms characterized by temperature-dependent sex determination. However, substances producing androgenic effects typically lack potency when tested in laboratory settings and are virtually unstudied in field settings. Here, we assay levels of a synthetic androgen, 17a-methyltestosterone (MT), in a heavily male-biased population of American crocodiles in the Tempisque River Basin of Costa Rica based on the recent hypothesis that this chemical is an EDC in developing crocodilian embryos. The presence of MT was documented in a…
Inhibition by Fendiline of the Transient Outward Current in Rat Ventricular Cardiomyocytes
1999
The effects of fendiline on the transient outward current (Ito) were investigated in rat ventricular cardiomyocytes. Extracellularly applied fendiline reduced peak and steady-state current amplitude of Ito; the inactivation of Ito was accelerated by the drug, which reflects onset of block. The described effects were concentration dependent: half-maximal effects were achieved at approximately 3 microM fendiline. Intracellularly applied fendiline (3 microM) did not affect Ito within 5 min. The steady-state current amplitude of Ito was more efficiently suppressed by the drug at 22 +/- 1 degrees C than at 36 +/- 1 degrees C. The recovery of Ito was analyzed by the application of twin depolarizi…
La conoscenza per la gestione dell'edilizia scolastica del Comune di Palermo
2008
Contraddizioni urbanistiche della Zona Espansione Nord 2 a Palermo
2008
Viene sviluppata una lettura del quartiere ZEN di Palermo sulla base di conoscenze dirette vissute nel periodo di formazione del progetto. Dal testo si evince come il progetto voleva riproporre le dimensioni dell’insula del centro storico di Napoli. Gli errori principali appaiono essere l’accentuato isolamento che il quartiere ha subito nel tempo, il rapporto che le costruzioni hanno con l’impianto viario, l’assenza di servizi della vita collettiva. I rimedi adottati dal Prg di Palermo accentuano l’isolamento affidando al diradamento la possibilità dell’integrazione, mentre sarebbe più opportuno produrre un contesto di maggiore densità capace di assorbire lo ZEN nella città esistente anche …
Aging resistance of bio-epoxy jute-basalt hybrid composites as novel multilayer structures for cladding
2017
Abstract Aging resistance of jute reinforced laminates is compared with two jute/basalt hybrid laminates prepared with different stacking sequences (i.e., sandwich and intercalated configuration). To this aim, composites are exposed to cyclic conditions comprising hygrothermal stress and UV radiation to promote an accelerated aging, for a period of 84 days. Specimens of each laminate are tested after 14, 28, 56 and 84 days, respectively. Quasi-static flexural tests, Charpy impact tests and dynamic mechanical tests are performed according to international ASTM and ISO standards. Furthermore, scanning electron microscopy and differential scanning calorimetry are used to evaluate the morpholog…
Service Life of Cementitious Photocatalytic Paints Newly Formulated
2013
The use of photocatalytic products for surface coating of buildings contributes to the sustainability of building interventions, due to the reduction of some atmospheric pollutants and self-cleaning attitude. The world market produces a wide range of coatings, applied in limited thickness, transparent and opaque, high initial performance, although data on their durability are still missing. The knowledge of the performance over time of such innovative products is necessary according to the new EU Regulation No. 305/2011, which introduced for construction works, the seventh requirement on their sustainability and particularly their durability. The study concerns the evaluation of the durabil…
Experimental evaluation of the durability of innovative cementitious coatings: photocatalytic activity and colour
2012
Today, in a world context characterized by high pollution levels and increasingly limited natural resources, even in the building sector, focusing on environmental issues, through energy saving and a more rational use of these resources, both during construction and management, is fundamental. An important contribution in this direction is given by the knowledge of the durability of products and building components, especially when innovative products are applied and no information are available on the reliability and service life. The research concerns the evaluation of the durability of cement-based photocatalytic coatings ("rasanti" in the Italian diction), containing different types of …
Due Diligence Matrix for Main User Groups of Financial Analysis
2014
Abstract Today the financial analysis indicators of an enterprise are topical for both internal and external users of an enterprise. Unfortunately, often to analyze the financial status of an enterprise and to identify the potential of an enterprise, it is not enough to have customary financial analysis indicators. In this paper, the data of the research that was conducted by the end of the year 2013 has been used. 1935 respondents took part in the survey – representatives of the leading business sectors in Latvia and representatives of the large and medium-sized enterprises. In the research, the authors have applied quantitative and qualitative methods of economics such as the mathematical…
Substituted 1,4-Diaza-1,3-butadiene Monocyclopentadienyl Titanium Complexes. Crystal Structure of Ti(η5-C5Me5)(η4-iPrNCHCHNiPr)Me
2000
We report the synthesis of 1,4-diaza-1,3-butadiene (dad) complexes Ti(η5-C5R5)(η4-R‘2-dad)Cl (R = H, Me; R‘ = iPr, tBu) by reaction of Ti(η5-C5R5)Cl3 (R = H, Me) with the dilithium salts of diisopropyl- and di-tert-butyl-substituted 1,4-diaza-1,3-butadienes (Li2[R‘2-dad]). Alkylation of the pentamethylcyclopentadienyl diisopropyl and di-tert-butyl derivatives with methylmagnesium chloride and methyllithium gave complexes Ti(η5-C5Me5)(η4-iPr2-dad)Me and Ti(η5-C5Me5)(η4-tBu2-dad)Me, respectively. Addition of excess water to di-tert-butyl chloro complexes gave the oxo-bridged complexes [{Ti(η5-C5R5)(η4-tBu2-dad)}2(μ-O)] (R = H, Me). The temperature-dependent spectroscopic behavior of Ti(η5-C5H…
Proprietà e uso degli impermeabilizzanti: classificazione e caratteristiche
2014
L'articolo presenta i risultati di uno studio condotto sui sistemi di impermeabilizzazione dell'involucro edilizio.Viene proposta una classificazione dei prodotti in commercio rispetto: al materiale costituente, alle prestazioni ed al tipo di commercializzazione.Lo studio affronta problematiche tecnologiche ma anche normative in modo da fornire uno strumento per la scelta più appropriata in relazione alle richieste dell'utenza.