Search results for "DISCIPLINE"

Psychopharmacological treatment of bipolar disorder in Latin American

2011

Abstract Objective This study assessed the treatment preferences among Latin American psychiatrists for their bipolar disorder patients and if these preferences reflect the current guidelines. Methods We designed a survey comprised of 14 questions. All the questions were aimed at the treatment of bipolar I patients only. We distributed the survey by hand or e-mail to psychiatrists in eight different countries: Argentina, Brazil, Colombia, Costa Rica, Ecuador, Mexico, Peru and Venezuela. Between May 2008 and June 2009, we were able to gather 1143 surveys. Results As the initial choice of treatment for a bipolar patient who debuts with mania, 61.3% choose a combination of an atypical antipsyc…

Sofferenza, malessere e disgrazia. : Metafore del dolore e senso del male nell'opera paleo-babilonese "Un uomo e il suo dio": un approccio interdisci…

2012

The Old-Babylonian text “A man and his god” has enjoyed a wide reputation for its many parallels with the biblical story of Job, and has been the subject of accurate philological analysis. This composition describes the suffering and pain of desperate man calls his God for healing. The aim of this work is to show how you can apply to the Mesopotamian literary texts dealing with the issue of suffering, pain and discomfort-disgrace, the theoretical and methodological tools of medical anthropology. An anthropological approach to the problem of illness in Mesopotamia can understand, in a deeper sense, the symbolic, socio-cultural and political complexity. The essay provides much food for though…

Smertekartlegging og smertelindring hos pasienter med demens: Utfordringer og dilemmaer

2013

Published version of an article in the journal: Vård i Norden. Also available from the publisher at: http://www.artikel.nu/Public/Main.aspx Aim: to explore nurses' experiences with pain assessment and pain relieving in patient with dementia. Background: research shows that patients with dementia are still suffering from unnecessary pain. The reason it may be nurses difficulty to interpret and map patients’ pain. Method: data were collected through three different focus group interviews. A semi – structured interview guide was developed to answer the research question. Data were analyzed by using a content analysis in four steps. Findings: The findings are divided into three sub – categories…

Interim Report on the Research Phase

1993

This is the report of one year of interdisciplinary team research in preparation of the Dassenetch Integrated Development Program (DIDP), SNV (Netherlands Development Organization) – ETHIOPIA

Written Past: Explorers’ Histories

2018

First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study

2021

Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…

Beyond the lessons learned from the COVID-19 pandemic: opportunities to optimize clinical trial implementation in oncology.

2021

Abstract The COVID-19 pandemic affected millions of people globally with lasting effects on society, patients, investigators and health institutions. Clinical trials, our best tool to improve cancer treatment for patients through testing the clinical value of a new treatment, have been affected by the pandemic. The pandemic footprint represents both a risk of compromising development of new therapies and an opportunity to elicit discussion over a portfolio of broader reforms, applicable irrespective of pandemics, in order to improve the design and implementation of clinical trials in oncology. The administrative load should be reduced, without affecting the quality of research and principle…

Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts

2018

Source at https://doi.org/10.1186/s13058-018-1073-0. Licensed CC BY-NC-ND 4.0. Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction. Methods: We built two models, for ER+ (ModelER+) and ER- tumors (ModelER-) , respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Discrimination (C-statistic) and calibration (the agreement between predicted and observed tumor risks)…

Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol…

2021

Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-f…

Mitotane Concentrations Influence Outcome in Patients With Advanced Adrenocortical Carcinoma

2020

Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC). However, limited evidence is available regarding the impact of plasma mitotane levels on patient outcome. To address this question, we retrospectively analyzed patients with advanced ACC treated with mitotane for &ge