Search results for "DISCOVERY"
showing 10 items of 4119 documents
Zum Mg-Gehalt von Serum und Erythrocyten bei Kranken mit Ichthyosis vulgaris
1967
Bei 10 Ichthyosis vulgaris-Kranken wurde in Serum und Erythrocyten die Mg-Konzentration bestimmt. Es fand sich ein statistisch signifikant erniedrigter Mg-Erythrocytenspiegel bei normalen Serumwerten.
Amyloid-Nachweis in der Haut bei Mycosis fungoides
1965
Der von mehreren Autoren angegebene spezifische polarisationsoptische Kongorot-Nachweis fur Amyloid wurde an der Haut von zwolf Fallen mit Mycosis fungoides gefuhrt. Wahrend die Darstellung des Amyloids im Hellfeld nicht gelang, konnte mit dieser Tcchnik die typische grune anomale Polarisationsfarbe an Faserstrukturen bei allen Fallen nachgewiesen und der sog. perikollagenen Amyloidose zugeordnet werden.
Transketolase-Hemmung durch D-Xylose als Ursache f�r Ketopentosurie nach Xylose-Belastung
1965
D-Xylose hemmt Transketolase in Hamolysaten und Leberhomogenaten in kompetitiver Weise. Die Inhibitor-Konstante fur D-Xylose liegt in der gleichen Grosenordnung wie die Xylose-Blutspiegel nach oraler Belastung. Es wird daher angenommen, das die Ursache fur die gesteigerte Ketopentose-Ausscheidung nach Xylose-Belastung in der Transketolase-Hemmung zu suchen ist.
�ber den Wirkungsmechanismus von Reserpin
1959
Zur Verteilung der LDH-Isoenzyme im Serum von Kranken mit Schuppenflechte
1968
Die Verteilung der LDH-Isoenzyme im Serum von Kranken mit Psoriasis vulgaris last sich am ehesten als ein Hinweis auf deren Herkunft aus der Skeletmuskulatur auffassen.
Topical Fluoride for Preventing Dental Caries in Children and Adolescents
2012
The use of topically applied fluoride has been widely researched as a means to reduce the risk of dental caries in conjunction with other treatment modalities (mechanical oral hygiene, dietary control, antimicrobial intervention, pit and fissure sealants). There is overwhelming evidence that reports not only the significance and importance of the use of fluoride as a caries-preventive agent, but also how safe fluoride application is when used appropriately, particularly in higher risk individuals and populations. This paper reviews the caries-protective benefits of topical fluoride application in children and adolescents, with an emphasis on the clinical efficacy and safety of the vehicles …
Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnos…
2021
Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment …
Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.
2016
Cancer stem cells (CSCs) have been identified in several solid malignancies and are now emerging as a plausible target for drug discovery. Beside the questionable existence of CSCs specific markers, the expression of CD133 was reported to be responsible for conferring CSC aggressiveness. Here, we identified two G-rich sequences localized within the introns 3 and 7 of the CD133 gene able to form G-quadruplex (G4) structures, bound and stabilized by small molecules. We further showed that treatment of patient-derived colon CSCs with G4-interacting agents triggers alternative splicing that dramatically impairs the expression of CD133. Interestingly, this is strongly associated with a loss of C…
Analysis of Contact Traces of Cannabis by In-Tube Solid-Phase Microextraction Coupled to Nanoliquid Chromatography
2018
Because of its inherent qualities, in-tube solid-phase microextraction (IT-SPME) coupled on-line to nanoliquid chromatography (nanoLC) can be a very powerful tool to address the new challenges of analytical laboratories such as the analysis of traces of complex samples. This is the case of the detection of contact traces of drugs, especially cannabis. The main difficulties encountered in the analysis of traces of cannabis plants on surfaces are the low amount of sample available (typically <
A review of the biological and pharmacological activities of saponins.
1996
Summary This paper reviews the important biological and pharmacological activities of saponins reported over the last few years. These include cancer-related activity, as well as antiphlogistic and antiallergic, immunomodulating, antihepatotoxic, antiviral, hypoglycemic, antifungal and molluscicidal activities. The action of saponins on the cardiovascular, central nervous, and endocrine systems and other miscellaneous effects are also discussed.