Search results for "DISEASES"
showing 10 items of 20537 documents
Metabolomics: An Emerging Approach to Understand Pathogenesis and to Assess Diagnosis and Response to Treatment in Spondyloarthritis
2022
Spondyloarthritis (SpA) is a group of rheumatic diseases whose pathogenesis relies on a complex interplay between genetic and environmental factors. Over the last several years, the importance of the alteration of the gut microbiota, known as dysbiosis, and the interaction of bacterial products with host immunity have been highlighted as intriguing key players in SpA development. The recent advent of the so called “-omics” sciences, that include metabolomics, opened the way to a new approach to SpA through a deeper characterisation of the pathogenetic mechanisms behind the disease. In addition, metabolomics can reveal potential new biomarkers to diagnose and monitor SpA patients. The aim of…
Multidimensional instruments with an integral approach to identify frailty in community-dwelling people: protocol for a systematic psychometric review
2019
IntroductionAn increasing number of investigations highlight the complex nature of frailty; therefore, the use of multidimensional assessment instruments could be useful in clinical decision-making. Frail people are found mainly in the community setting which is why this is the ideal environment for early screening and intervention. For this purpose, it is necessary to have valid, time-effective and easy-to-use frailty assessment instruments. The aim of this review is to critically appraise, compare and summarise the quality of the measurement properties of all multidimensional instruments with an integral approach to identify frailty in community-dwelling people.Methods and analysisMedline…
An Immersive Motor Protocol for Frailty Rehabilitation
2019
Frailty is a pre-clinical condition that worsens physical health and quality of life. One of the most frequent symptoms of frailty is an increased risk of falling. In order to reduce this risk, we propose an innovative virtual reality motor rehabilitation program based on an immersive tool. All exercises will take place in the CAVE, a four-screen room with a stationary bike. The protocol will include two types of exercises for the improvement of balance: “Positive Bike” and “Avoid the Rocks.” We will choose evaluation scales related to the functional aspects and subjective perception of balance. Our aim is to prove that our innovative motor rehabilitation protocol is as effective as or more…
Pathogenesis and autoimmunity initiated by a viral protein-induced apoptotic bodies
2016
Ihmisen parvovirus B19 (B19) on laajalle levinnyt, yleinen virus, joka aiheuttaa lapsissa parvorokkoa (viides tauti). Aikuisille B19 aiheuttaa erinäisiä sairauksia, muun muassa nivelkipuja ja – tulehdusta, anemiaa, sekä raskaana oleville sikiöpöhöä. Lisäksi B19 infektio saattaa johtaa autoimmuunisairauksiin, kuten punahukkaan (systemic lupus erythematosus, SLE), nivelreumaan ja sydänlihastulehdukseen. Toisaalta infektio voi olla myös täysin oireeton. Mekanismit, jotka johtavat B19 tartunnasta autoimmuunisairauteen, ovat vielä tuntemattomia. Kuitenkin tiedetään, että B19:n ei-rakenteellinen proteiini NS1 on soluille tuhoisa ja aiheuttaa niiden kuoleman (apoptoosin) muodostaen solunjäännösten…
Restoration of High Frequency Auditory Perception After Robot-Assisted or Manual Cochlear Implantation in Profoundly Deaf Adults Improves Speech Reco…
2021
Background and Purpose: Robot-assisted cochlear implantation has recently been implemented in clinical practice; however, its effect on hearing outcomes is unknown. The aim of this preliminary study was to evaluate hearing performance 1 year post-implantation whether the electrode array was inserted manually or assisted by a robot.Methods: Forty-two profoundly deaf adults were implanted either manually (n = 21) or assisted by a robot (RobOtol®, Collin, Bagneux, France) with three different electrode array types. Participants were paired by age, and electrode array type. The scalar position of the electrode array in the cochlea was assessed by 3D reconstruction from the pre- and post-implant…
Scoliosis Research Society (SRS-30) kyselykaavakkeen pätevyys selkä- ja alaraajakipuisilla aikuispotilailla
2017
Scoliosis Research Society questionnaire version 30 (SRS-30) has originally been developed to measure disability and health related quality of life in patients with adolescent idiopathic scoliosis but it has proven valid also in adults with degenerative spinal disease. Degenerative spine disease has many phases and manifestations including disc degeneration, spondylarthrosis, spondylolistheses and compromise to neural tissue. The aim of this study was to test whether the SRS-30 questionnaire is valid in adults with different sources of pain: local back pain, radicular pain or their combination. Structural analysis of the SRS-30 and comparison with RAND-36 and ODI was performed. The deformit…
DEPS-testin luotettavuus ja pätevyys aikuisilla selkäpotilailla
2017
The Depression Scale (DEPS) is a patient-reported outcome instrument developed to recognize depressive symptoms. This study measured the psychometric properties of the DEPS among patients with degenerative spinal disease. Altogether 637 patients were included in the analysis. Main research question was whether the DEPS would meet pertinent psychometric criteria for reliability and validity. The results of analyses supported the DEPS instrument as a reliable and valid test to measure depressive symptoms among adult patients with spinal disease fulfilling the psychometric criteria. nonPeerReviewed
Odontogenic Cysts: Analysis of 2.944 cases in Chile
2007
Introduction: Odontogenic cysts constitute a group of frequent intraosseous lesions characteristic in the maxillary bones and one of the main causes of the destruction of these bones. In Chile there are no retrospective studies of these lesions as a whole. Objective: The purpose of this study is to determine the frequency of these lesions in so far as they were diagnosed and registered in the Referral Institute for Oral Pathology (IREPO) of the University of Chile in two age groups as well as to analyze and to compare the data obtained with the data published in previous studies. Material and Method: We studied the records from IREPO of the University of Chile for the period between 1976 an…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
Questing abundance of adult taiga ticks Ixodes persulcatus and their Borrelia prevalence at the north-western part of their distribution
2020
Background Because ixodid ticks are vectors of zoonotic pathogens, including Borrelia, information of their abundance, seasonal variation in questing behaviour and pathogen prevalence is important for human health. As ticks are invading new areas northwards, information from these new areas are needed. Taiga tick (Ixodes persulcatus) populations have been recently found at Bothnian Bay, Finland. We assessed seasonal variation in questing abundance of ticks and their pathogen prevalence in coastal deciduous forests near the city of Oulu (latitudes 64–65°) in 2019. Methods We sampled ticks from May until September by cloth dragging 100 meters once a month at eight study sites. We calculated a…