Search results for "DISORDERS"

Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group

2016

Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…

Tailored treatments in internal rectal prolapse

2020

Background: Internal rectal prolapse is commonly reported in patients suffering pelvic floor disorders, such as obstructive defecation and incontince. Unfortunately, its treatment not always offers a symptoms resolution. Material and methods: To investigate the correct management and its influence in symptoms resolution, we investigated patients submitted to hierarchic therapeutic options from conservative to surgical treatments. An evaluation of the appropriate treatment tailored on the entity of the prolapse was proposed. Results: We investigated 84 patients [64 F, 20 M (median age 52)]. In 44 a symptoms resolution was obtained with medical therapy. To 40 patients biofeedback rehabilitati…

Transcriptional Activity and Nuclear Localization of Cabut, the Drosophila Ortholog of Vertebrate TGF-β-Inducible Early-Response Gene (TIEG) Proteins

2011

Background Cabut (Cbt) is a C2H2-class zinc finger transcription factor involved in embryonic dorsal closure, epithelial regeneration and other developmental processes in Drosophila melanogaster. Cbt orthologs have been identified in other Drosophila species and insects as well as in vertebrates. Indeed, Cbt is the Drosophila ortholog of the group of vertebrate proteins encoded by the TGF-s-inducible early-response genes (TIEGs), which belong to Sp1-like/Kruppel-like family of transcription factors. Several functional domains involved in transcriptional control and subcellular localization have been identified in the vertebrate TIEGs. However, little is known of whether these domains and fu…

The mediating role of emotion regulation in transdiagnostic cognitive behavioural therapy for emotional disorders in primary care: Secondary analyses…

2022

Background: Emotional disorders are highly prevalent in primary care. Transdiagnostic cognitive behavior therapy (TD-CBT) is a promising treatment of emotional disorders. In this study, we evaluated several emotion regulation strategies as potential mediators of treatment outcomes in a clinical sample of primary care. Methods: A total of 1061 primary care patients were included in a randomized clinical trial comparing treatment- as-usual (TAU) to TD-CBT+TAU. Of these, 631 (TAU=316; TD-CBT+TAU=315) completed the full treatment and all pre- and post-treatment scales to assess symptoms (anxiety, depression, somatization), emotion regulation strategies (worry, rumination, negative metacognition…

Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels

2011

10 pages, 5 figures. 21779322[PubMed] PMCID: PMC3136927

Fibromuscular dysplasia in a transplanted kidney

1998

The impact of a history of psychotic symptoms on cognitive function in euthymic bipolar patients: a comparison with schizophrenic patients and health…

2011

BACKGROUND: About two-thirds of patients with bipolar disorder (BD) have a lifetime history of at least one psychotic symptom. Objective: To compare the neurocognitive performance of four groups: BD patients with and without a history of psychotic symptoms (BD HPS+ and BD HPS-, respectively); patients with schizophrenia (SZ); and healthy control (HC) subjects. METHOD: In this cross-sectional study, 35 stabilized patients with SZ, 79 euthymic (44 HPS+ and 35 HPS-) patients with BD, and 50 HC were administered a comprehensive battery of neuropsychological tests. RESULTS: There was worse neurocognitive functioning in both BD and SZ patients compared to HC. Overall, data from both groups of BD …

A participatory ergonomics program in a chemical company

2012

Se describe una intervención de ergonomía participativa iniciada en abril de 2010 en una empresa del sector químico de la Comunidad Valenciana. Se presentó el programa de intervención en la empresa, se acordó el ámbito de la intervención (dos líneas, 24 trabajadores y trabajadoras) y se constituyó un grupo de trabajo (Grupo Ergo, formado por personas responsables, técnicos y delegados de prevención de la empresa) encargado de guiar la intervención. Se recogió mediante cuestionario información acerca de daños y riesgos ergonómicos en los trabajadores y trabajadoras de los puestos seleccionados. Esta información fue analizada por el Grupo Ergo y discutida posteriormente en círculos de prevenc…

Intervención de ergonomía participativa en una empresa del sector químico A participatory ergonomics program in a chemical company

2012

Se describe una intervención de ergonomía participativa iniciada en abril de 2010 en una empresa del sector químico de la Comunidad Valenciana. Se presentó el programa de intervención en la empresa, se acordó el ámbito de la intervención (dos líneas, 24 trabajadores y trabajadoras) y se constituyó un grupo de trabajo (Grupo Ergo, formado por personas responsables, técnicos y delegados de prevención de la empresa) encargado de guiar la intervención. Se recogió mediante cuestionario información acerca de daños y riesgos ergonómicos en los trabajadores y trabajadoras de los puestos seleccionados. Esta información fue analizada por el Grupo Ergo y discutida posteriormente en círculos de prevenc…

A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an e…

2018

Abstract. Objective: We examined predictors and moderators of treatment outcome in mothers and children diagnosed with ADHD in a large multicentre RCT. Method: In total, 144 mother-child dyads with ADHD were randomly assigned to either a maternal ADHD treatment (group psychotherapy and open methylphenidate medication, TG) or to a control treatment (individual counselling without psycho- or pharmacotherapy, CG). After maternal ADHD treatment, parent-child training (PCT) for all mother-child dyads was added. The final analysis set was based on 123 dyads with completed primary outcome assessments (TG: n = 67, CG: n = 56). The primary outcome was the change in each child’s externalizing sympto…