Search results for "DNA"
showing 10 items of 6803 documents
The Value of Liquid Biopsies for Guiding Therapy Decisions in Non-small Cell Lung Cancer
2019
Early evolutionary colocalization of the nuclear ribosomal 5S and 45S gene families in seed plants: evidence from the living fossil gymnosperm Ginkgo…
2012
In seed plants, the colocalization of the 5S loci within the intergenic spacer (IGS) of the nuclear 45S tandem units is restricted to the phylogenetically derived Asteraceae family. However, fluorescent in situ hybridization (FISH) colocalization of both multigene families has also been observed in other unrelated seed plant lineages. Previous work has identified colocalization of 45S and 5S loci in Ginkgo biloba using FISH, but these observations have not been confirmed recently by sequencing a 1.8 kb IGS. In this work, we report the presence of the 45S–5S linkage in G. biloba, suggesting that in seed plants the molecular events leading to the restructuring of the ribosomal loci are much o…
DNA extraction from phytoseiid specimens preserved on a glass slide and molecular diagnostic
2010
This study focuses on the diagnostic of seven species of mite belonging to the family of Phytoseiidae; very important biocontrol agents of phytophagous mites. However, they are morphologically very similar and specific diagnostic is very difficult in fact using the traditional identification methods it is uncertain to identify a species especially when Authors use different characters, very often not stable in the time. In the 60’s M.me Athias-Henriot took into consideration the insemination apparatus that is considered a stable character in the time. According to her, the shape of this apparatus could be considered a major criterion for genus distinction. The aim of the present study is to…
Pojednana różnorodność – koncepcja pokojowej koegzystencji na przykładzie Górnego Śląska w myśli abp. Alfonsa Nossola
2019
Pluralizm współczesnych społeczeństw w zglobalizowanym świecie nieodłącznie wiąże się z napięciami, konfliktem interesów i rozbieżnymi poglądami dotyczącymi postrzegania świata i praktycznych zachowań ludzi. W kontekście złożoności relacji międzyludzkich oraz różnorodności wyrażającej się na płaszczyźnie politycznej, kulturowej, religijnej, społecznej i światopoglądowej rodzi się pytanie o możliwość pokojowej koegzystencji ludzi i grup społecznych. Odpowiedzią na to pytanie jest idea pojednanej różnorodności, która zrodziła się w konkretnym kontekście historycznym na Górnym Śląsku, a jej wypracowania, rozwinięcia i zastosowania do złożonych problemów społeczno-kulturowo-religijnych dokonał …
Endocrine disrupters: the new players able to affect the epigenome
2015
Epigenetics represents the way by which the environment is able to program the genome; there are three main levels of epigenetic control on genome: DNA methylation, post-translational histone modification and microRNA expression. The term Epigenetics has been widened by NIH to include “both heritable changes in gene activity and expression but also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.” These changes might be produced mostly by the early life environment and might affect health influencing the susceptibility to develop diseases, from cancer to mental disorder, during the entire life span. The most studied environmental i…
Pompy ciepła jako efektywne i ekologiczne systemy ogrzewania
2016
W artykule scharakteryzowano pompy ciepła i dokonano ich klasyfikacji. Przedstawiono wpływ czynników chłodniczych stosowanych w pompach ciepła na środowisko naturalne. Dokonano porównania różnych rozwiązań systemów ogrzewania z zastosowaniem pomp ciepła za pomocą współczynników COP i SPF. Przeanalizowano rynek pomp ciepła w Polsce na przestrzeni kilku ostatnich lat.
Mitochondrial sequence analysis of Salamandra taxa suggests old splits of major lineages and postglacial recolonizations of Central Europe from disti…
2000
Representatives of the genus Salamandra occur in Europe, Northern Africa and the Near East. Many local variants are known but species and subspecies status of these is still a matter of dispute. We have analysed samples from locations covering the whole expansion range of Salamandra by sequence analysis of mitochondrial D-loop regions. In addition, we have calibrated the rate of divergence of the D-loop on the basis of geologically dated splits of the closely related genus Euproctus. Phylogenetic analysis of the sequences suggests that six major monophyletic groups exist (S. salamandra, S. algira, S. infraimmaculata, S. corsica, S. atra and S. lanzai) which have split between 5 and 13 milli…
Antipsykoottisen lääkkeen pitkäaikaiset vaikutukset rotan etuaivokuorella DNA-sirumenetelmällä tutkittuna
2005
Pathogenesis and autoimmunity initiated by a viral protein-induced apoptotic bodies
2016
Ihmisen parvovirus B19 (B19) on laajalle levinnyt, yleinen virus, joka aiheuttaa lapsissa parvorokkoa (viides tauti). Aikuisille B19 aiheuttaa erinäisiä sairauksia, muun muassa nivelkipuja ja – tulehdusta, anemiaa, sekä raskaana oleville sikiöpöhöä. Lisäksi B19 infektio saattaa johtaa autoimmuunisairauksiin, kuten punahukkaan (systemic lupus erythematosus, SLE), nivelreumaan ja sydänlihastulehdukseen. Toisaalta infektio voi olla myös täysin oireeton. Mekanismit, jotka johtavat B19 tartunnasta autoimmuunisairauteen, ovat vielä tuntemattomia. Kuitenkin tiedetään, että B19:n ei-rakenteellinen proteiini NS1 on soluille tuhoisa ja aiheuttaa niiden kuoleman (apoptoosin) muodostaen solunjäännösten…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…