Search results for "DOI"

Les autrices suédoises du genombrott

2019

International audience; No abstract.

Base-promoted direct amidation of esters: beyond the current scope and practical applications

2022

The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chemistry. The intensive research in this area has led to the development of a number of new methods to achive this transformation. However, to date, the existing literature is more methodological and in many instances lacks practical directions. Therefore, the full potential of this transformation is yet to be revealed by broadening the substrate scope. In a search for new practical applications of the amidation reaction, herein we present a comprehensive study of a number of base-promoted direct amidations that encompass a wide range of amines and es…

Chemical composition, antimicrobial and antioxidant activity of the essential oils from Pimpinellatragium Vill. subsp. glauca (C. Presl.) C. BrulloBr…

2013

The essential oils from flowers, leaves and stems hydrodistilled from Pimpinella tragium Vill, subsp. glauca were characterised by GC and gas chromatography-mass spectrometry analysis. The C-12 nor-sesquiterpenes are the principal class of metabolites (56.6-70.6%) among which geijerene (28.9÷49.3%) and pregeijerene (10÷19.1%) predominate. Antimicrobial and antioxidant activities were evaluated. The minimum inhibitory concentration values indicate that oil obtained from the stems is the most active for antimicrobial activities and the sample with the biggest antioxidant capacity is the flower oil.

Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia

2020

Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.

Costs and benefits of plant allelochemicals in herbivore diet in a multi enemy world

2015

Sequestration of plant defensive chemicals by herbivorous insects is a way of defending themselves against their natural enemies. Such herbivores have repeatedly evolved bright colours to advertise their unpalatability to predators, i.e. they are aposematic. This often comes with a cost. In this study, we examined the costs and benefits of sequestration of iridoid glycosides (IGs) by the generalist aposematic herbivore, the wood tiger moth, Parasemia plantaginis. We also asked whether the defence against one enemy (a predator) is also effective against another (a parasitoid). We found that the larvae excrete most of the IGs and only small amounts are found in the larvae. Nevertheless, the a…

Molecular systematics and phytochemistry of Rehmannia (Scrophulariaceae)

2007

Abstract The relationships between the six known species of Rehmannia were investigated. With regard to the content of iridoid glucosides, caffeoyl phenylethanoid glycosides (CPGs) and ionone glucosides, no conclusions could be drawn. Phylogenetic analysis of DNA sequence data (ITS region, trnL-F region and rps 16 intron) reveal a well-resolved topology in which Rehmannia glutinosa and Rehmannia solanifolia and Rehmannia piasezkii and Rehmannia elata are well-supported species pairs. Rehmannia chingii is sister to the rest of the genus, which is congruent with its distribution distant to the other species of the genus.

Typification of the Presl’s name Calamintha canescens (Lamiaceae)

2021

Calamintha canescens is a taxon described in the “Flora Sicula” by K. B. Presl (1826), following the visit made to Sicily a few years earlier (March-July 1817). In the protologue Presl does not report any data on the distribution in Sicily of this taxon that will be almost completely forgotten in later floristic works. Only Nyman (1881) and later Šilić (1979) consider it as a variety respectively of Calamintha nepeta (L.) Savi and C. glandulosa (Req.) Benth. Following the review of a group of critical European taxa belonging to the genus Clinopodium L., lately Melnikov (2016) recovers the ancient taxon Calamintha canescens C. Presl and transfers it to the genus Clinopodium L. Also, the auth…

Diamondoids: functionalization and subsequent applications of perfectly defined molecular cage hydrocarbons

2014

The term “diamondoid” describes cage hydrocarbon molecules that are superimposable on the diamond lattice. Diamondoids that are formally built by face-fusing of adamantane units, namely diamantane, triamantane, tetramantane, etc., have fascinated chemists since the beginning of the last century. The functionalization of these perfectly defined (C,H)-molecules is described here. Thus, diamondoid halides and diamondoid alcohols are first rank precursors for amino and phosphine-substituted diamondoids that have proved to be highly useful in therapeutic applications and metal catalysis, respectively. The extent of functionalization and polyfunctionalization achieved for adamantane and diamantan…

Nanodiamonds: Emergence of Functionalized Diamondoids and Their Unique Applications

2015

LE MIGRAZIONI COME NELLA RAPPRESENTAZIONE DI UN GIANO BIFRONTE. LE STRADE SICURE E LEGALI D’INGRESSO DEI MIGRANTI PROFUGHI IN ITALIA.

2019

L’ingresso e la presenza in Italia di persone migranti è, fin da sempre, un tema di confronto fra coloro che ritengono che sia giusto favorire un’adeguata accoglienza e coloro che sostengono il contrario. Il presente contributo intende illustrare le forme possibili di ingresso legale di migranti profughi nei paesi dell’Unione Europea, con particolare attenzione all’ingresso legale in Italia. A partire dal 2014, il governo italiano ha manifestato l’intenzione di sviluppare un programma di reinsediamento al fine di dare ai migranti profughi una adeguata protezione. Attualmente, attraverso la rete dei Corridoi Umanitari, sotto il coordinamento del Dipartimento per le Libertà Civili e Immigrazi…