Search results for "DOMAIN"
showing 10 items of 2485 documents
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Ju…
2003
The molecular mode of cell killing by the antiviral drug (E)-5-(2-bromovinyl-2'-deoxyuridine (BVDU) was studied in Chinese hamster ovary (CHO) cells stably transfected with the thymidine kinase gene (tk) of varicella zoster virus (CHO-VZVtk). The colony-forming ability of the cells was reduced to <1% at a concentration of approximately 1 microM BVDU, whereas for nontransfected cells or cells transfected with tk gene of herpes simplex virus type 1 (CHO-HSVtk), a 1000-fold higher dose was required to achieve the same response. BVDU inhibited thymidylate synthase in CHO-VZVtk but not in CHO-HSVtk and control cells. On the other hand, the drug was incorporated into DNA of VZVtk- and HSVtk-expre…
Stability of radial symmetry for a Monge-Ampère overdetermined problem
2008
Recently the symmetry of solutions to overdetermined problems has been established for the class of Hessian operators, including the Monge-Ampère operator. In this paper we prove that the radial symmetry of the domain and of the solution to an overdetermined Dirichlet problem for the Monge-Ampère equation is stable under suitable perturbations of the data. © 2008 Fondazione Annali di Matematica Pura ed Applicata and Springer-Verlag.
Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome
1998
The LIM-homeodomain protein Lmxlb plays a central role in dorso-ventral patterning of the vertebrate limb1. Targeted disruption of Lmxlb results in skeletal defects including hypoplas-tic nails, absent patellae and a unique form of renal dysplasia (see accompanying manuscript by H. Chen et al.; ref. 2). These features are reminiscent of the dominantly inherited skeletal malformation nail patella syndrome (NFS). We show that LMX1B maps to the NFS locus and that three independent NFS patients carry de novo heterozygous mutations in this gene. Functional studies show that one of these mutations disrupts sequence-specific DNA binding, while the other two mutations result in premature terminatio…
Discovering learning paths on a domain ontology using natural language interaction
2005
The present work investigates the problem of determining a learning path inside a suitable domain ontology. The proposed approach enables the user of a web learning application to interact with the system using natural language in order to browse the ontology itself. The course related knowledge is arranged as a three level hierarchy: content level, symbolic level, and conceptual level bridging the previous ones. The implementation of the ontological, the interaction, and the presentation component inside the TutorJ system is explained, and the first results are presented.
Constraints on Cosmic Strings Using Data from the Third Advanced LIGO–Virgo Observing Run
2021
We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 data set. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks and, for the first time, kink-kink collisions.cA template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension, $G\mu$, as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models.cAdditionally, we develop and test a third model which interpolat…
Holographic duals of 6d RG flows
2018
A notable class of superconformal theories (SCFTs) in six dimensions is parameterized by an integer $N$, an ADE group $G$, and two nilpotent elements $\mu_\mathrm{L,R}$ in $G$. Nilpotent elements have a natural partial ordering, which has been conjectured to coincide with the hierarchy of renormalization-group flows among the SCFTs. In this paper we test this conjecture for $G=\mathrm{SU}(k)$, where AdS$_7$ duals exist in IIA. We work with a seven-dimensional gauged supergravity, consisting of the gravity multiplet and two $\mathrm{SU}(k)$ non-Abelian vector multiplets. We show that this theory has many supersymmetric AdS$_7$ vacua, determined by two nilpotent elements, which are naturally …
Non-supersymmetric AdS6 and the swampland
2021
We discuss infinite families of non-supersymmetric AdS$_6$ solutions in Type IIB string theory. They are siblings of supersymmetric solutions which are associated with $(p,q)$ 5-brane webs and holographically dual to 5d SCFTs engineered by those brane webs. The non-supersymmetric backgrounds carry identical 5-brane charges and are connected to the supersymmetric ones by RG flows. We study the stability of the non-supersymmetric solutions, identifying perturbative and non-perturbative decay channels for all the backgrounds explicitly available. We also identify likely decay mechanisms for solutions that have not been constructed explicitly but may be expected to exist based on brane web cons…
Domain wall junctions in a generalized Wess-Zumino model
1999
We investigate domain wall junctions in a generalized Wess-Zumino model with a Z(N) symmetry. We present a method to identify the junctions which are potentially BPS saturated. We then use a numerical simulation to show that those junctions indeed saturate the BPS bound for N=4. In addition, we study the decay of unstable non-BPS junctions.
Q7-branes and their coupling to IIB supergravity
2007
We show how, by making use of a new basis of the IIB supergravity axion-dilaton coset, SL(2,R)/SO(2), 7-branes that belong to different conjugacy classes of the duality group SL(2,R) naturally couple to IIB supergravity with appropriate source terms characterized by an SL(2,R) charge matrix Q. The conjugacy classes are determined by the value of the determinant of Q. The (p,q) 7-branes are the branes in the conjugacy class detQ = 0. The 7-branes in the conjugacy class detQ > 0 are labelled by three numbers (p,q,r) which parameterize the matrix Q and will be called Q7-branes. We construct the full bosonic Wess--Zumino term for the Q7-branes. In order to realize a gauge invariant coupling …
Domain walls in supersymmetric QCD: The taming of the zoo
2000
We provide a unified picture of the domain wall spectrum in supersymmetric QCD with Nc colors and Nf flavors of quarks in the (anti-) fundamental representation. Within the framework of the Veneziano-Yankielowicz-Taylor effective Lagrangian, we consider domain walls connecting chiral symmetry breaking vacua, and we take the quark masses to be degenerate. For Nf/Ncm** there is no domain wall. We numerically determine m* and m** as a function of Nf/Nc, and we find that m** approaches a constant value in the limit that this ratio goes to one.