Search results for "DOMAIN"

Shear design of high strength concrete beams in MRFs

2019

This paper presents the criteria for the shear design of high strength concrete (HSC) beams in moment resisting frames (MRFs). The formulation of an analytical model is provided for the case of beams with longitudinal reinforcement in the presence of transverse stirrups. The model is of additive type, in the meaning that the shear resistance of the beam is evaluated as the sum of several contributions. In particular, the contribution of concrete, longitudinal rebars, and transversal reinforcement are taken into account. Furthermore, for assessing the concrete contribution, a classical approach is followed, according to which two effects arise in the shear mechanism: the arc and the beam eff…

Monitoring soil volume wetness in heterogeneous soils by electrical resistivity. A field-based pedotransfer function.: A field-based pedotransfer fun…

2014

11 pages; International audience; Modern irrigation techniques require accurate, rapid, cost-effective, spatial measurement of soil moisture. Electrical Resistivity Tomography (ERT) meets most of these requirements, but needs to be calibrated for each use because it is very sensitive to differences in soil characteristics. In this study, a pedotransfer function approach is used to remove the need for site-specific calibration, allowing ERT to be used directly to measure soil moisture. The study site was a hillslope vineyard, where eight calcaric-cambisol soil profiles were identified. From 2012 to 2013, 23 000 soil volume wetness measurements were acquired by Time Domain Reflectometry, and …

Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling

2021

Bacterial phytochrome photoreceptors usually belong to two-component signaling systems which transmit environmental stimuli to a response regulator through a histidine kinase domain. Phytochromes switch between red light-absorbing and far-red light-absorbing states. Despite exhibiting extensive structural responses during this transition, the model bacteriophytochrome from Deinococcus radiodurans (DrBphP) lacks detectable kinase activity. Here, we resolve this long-standing conundrum by comparatively analyzing the interactions and output activities of DrBphP and a bacteriophytochrome from Agrobacterium fabrum (Agp1). Whereas Agp1 acts as a conventional histidine kinase, we identify DrBphP a…

Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells

2014

Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most frequently mutated tumor suppressor gene in cancers and mutant p53 protein (mutp53) can acquire gain of function (GOF) strongly contributing to malignancy. Studies thus far have not shown p53-GOF in osteosarcoma. Here, we investigated TP53 gene status/role in 3AB-OS cells-a highly aggressive CSC line previously selected from human osteosarcoma MG63 cells-to evaluate its involv…

Post-Translational Modifications of Nuclear Proteins in the Response of Plant Cells to Abiotic Stresses

2011

For a long time, in plant cells as in animal cells, the nucleus was only considered as the organelle in which fundamental mechanisms such as replication and transcription occurred. While strong efforts were deployed in order to identify important families of transcription factors such as MYB, WRKY or TGA families (Dubos et al., 2010; Rushton et al., 2010), a few attention was devoted to our lack of knowledge about their regulation in regard to the physiological conditions of the plant cells. Whereas the major importance of posttranslational modification of proteins is well established for several decades regarding cytosolic proteins, the last years have been characterized by the discovery t…

History of Mathematics: A Global Cultural Approach

2021

La financiación de las empresas mediterráneas de Alfonso el Magnánimo. Bailía General, Subsidios de Cortes y Crédito Institucional en Valencia (1419-…

2003

This article studies the role of the General Bailía of Valencia—the office for the management of the royal domain resources of the kingdom of Valencia- in the political and military projects of Alfonso V the Magnanimous in the Mediterranean. In this way its also analysed the role of the Parliament, a class representation of the kingdom, and the city of Valencia, main urban centre The incomes from the royal domain, the donations from the Parliaments as a representative assemblies, and the loans provided by the city of Valencia contributed in a decisive way to the guarantee of the economic viability of Alfonso Vs military expansion. It is right that the main instruments that the king had to a…

In search of an integrated framework of business longevity

2015

Even if the domain of business longevity has been enriched by the multidisciplinary nature of approaches used to investigate the phenomenon, the lack of a unifying perspective has impeded systematic research and caused definitional ambiguity. The main aim of this special issue is to extend existing knowledge on business longevity by integrating theoretical and empirical studies that adopt different approaches and perspectives. This is essential in order to identify the key factors of long-term success and the effects of longevity on firm performance. The multifaceted nature of business longevity research is mirrored in the five articles included in this special issue, that offer different a…

Anomalous behaviour of periodic domain structure in Gd-doped LiNbO3single crystals

2007

Atomic force microscopy studies of etching patterns, stability of regular domain structure, and anomalies of electrical characteristics in the 300 - 385 K range of a series of Gddoped lithium niobate single crystals grown under equal conditions are reported.

Gene expression of stem cells at different stages of ontological human development.

2013

Abstract Objectives To compare multipotent mesenchymal stem cells (MSCs) obtained from chorionic villi (CV), amniotic fluid (AF) and placenta, with regard to their phenotype and gene expression, in order to understand if MSCs derived from different extra-embryonic tissues, at different stages of human ontological development, present distinct stemness characteristics. Study design MSCs obtained from 30 samples of CV, 30 of AF and 10 placentas (obtained from elective caesarean sections) were compared. MSCs at second confluence cultures were characterized by immunophenotypic analysis with flow cytometry using FACS CANTO II. The expression of the genes Oct-4 (Octamer-binding transcription fact…