Search results for "DOMAIN"

Combined Therapy of Interferon Plus Ribavirin Promotes Multiple Adaptive Solutions in Hepatitis C Virus

2009

Hepatitis C virus (HCV) presents several regions involved potentially in evading antiviral treatment and host immune system. Two regions, known as PKR-BD and V3 domains, have been proposed to be involved in resistance to interferon. Additionally, hypervariable regions in the envelope E2 glycoprotein are also good candidates to participate in evasion from the immune system. In this study, we have used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples obtained just before initiation of therapy and after 6 or/and 12 months of treatment were available. A range of 25-100 clones per patient, genome region and time sample were obtained…

La teneur en lipides du régime affecte les capacitésd'absorption intestinale et la triglycéridémie postprandiale: contribution du récepteur nucléaire…

2007

The dietary long chain fatty acid have crucial functions into the organism such as energysource, eicosanoïdes synthesis, gene regulation). The fat disposal is essential and depend onintestinal barrier. It is well known that intestinal fat absorption is efficient. However, we don'tif the high triglycerides bioavailability of gut is attributable to inborn properties or to acquiredproperties. To answer this question, mice were subjected to a high-fat diet (40%, w/w) during21 days. We have shown that high-fat induces : 1) intestinal LCFA uptake, 2) intestinalmitotic index which leads to an increase of intestinal relative mass, 3) expression of genesinvolved in fatty uptake (Fatty Acid Transport…

Art Painting Testing with Terahertz Pulse and Frequency Modulated Continuous Wave

2017

Paintings of individuals or collections undergo aging over time. The work of art restorers consists of repairing these defects using techniques that respect the history of the work. Ultraviolet, infrared and visible light and X-rays are well known techniques for analyzing these defects, but Terahertz is also increasingly used. Several works have shown that it is possible to detect hidden layers and various defects via terahertz pulses. In a previous work, we have shown that it is possible to use terahertz radiation to detect defects in the context of a restoration of a painting with a speed increase compared to time domain imaging.

New Ordovician mitrates (Echinodermata, Stylophora) from the Ancenis Basin (South Armorican Domain, France): Palaeogeographic and palaeoenvironmental…

2006

8 pages; International audience; Fossil echinoderms are extremely rare in Ordovician deposits of the South Armorican Domain (SAD), a structurally complex area stacked to the Medio-North Armorican Domain during the Hercynian orogeny. Two new occurrences of mitrate stylophorans are documented in the eastern part of the SAD (Ancenis Basin). The youngest known specimen of Lagynocystis pyramidalis is described from the Schistes du Fresne Formation (Late Ordovician). Mitrocystites mitra is reported from the Pierre Meliere Formation (Middle Ordovician), and for the first time, outside of Bohemia. The presence of these two cool-adapted taxa (both abundant in the Prague Basin) in the Ancenis Basin d…

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

2020

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22&ndash

Beer-Lambert law for optical tissue diagnostics: current state of the art and the main limitations.

2021

Abstract. Significance: Beer–Lambert law (BLL) is a widely used tool for contact and remote determination of absorber concentration in various media, including living tissues. Originally proposed in the 18th century as a simple exponential expression, it has survived numerous modifications and updates. The basic assumptions of this law may not be fulfilled in real measurement conditions. This can lead to mistaken or misinterpreted results. In particular, the effects to be additionally taken into account in the tissue measurements include anisotropy, scattering, fluorescence, chemical equilibria, interference, dichroism, spectral bandwidth disagreements, stray radiation, and instrumental eff…

Parallel Schwarz methods for convection-dominated semilinear diffusion problems

2002

AbstractParallel two-level Schwarz methods are proposed for the numerical solution of convection-diffusion problems, with the emphasis on convection-dominated problems. Two variants of the methodology are investigated. They differ from each other by the type of boundary conditions (Dirichlet- or Neumann-type) posed on a part of the second-level subdomain interfaces. Convergence properties of the two-level Schwarz methods are experimentally compared with those of a variant of the standard multi-domain Schwarz alternating method. Numerical experiments performed on a distributed memory multiprocessor computer illustrate parallel efficiency of the methods.

2020

This work introduces a method to estimate reflectance, shading, and specularity from a single image. Reflectance, shading, and specularity are intrinsic images derived from the dichromatic model. Estimation of these intrinsic images has many applications in computer vision such as shape recovery, specularity removal, segmentation, or classification. The proposed method allows for recovering the dichromatic model parameters thanks to two independent quadratic programming steps. Compared to the state of the art in this domain, our approach has the advantage to address a complex inverse problem into two parallelizable optimization steps that are easy to solve and do not require learning. The p…

Correlation of quenched structural disorder and magnetism inTiFe2Laves-phase thin films

2002

In recent bandstructure calculations for the $C14$ Laves-phase intermetallic compound ${\mathrm{TiFe}}_{2}$ two energetically nearly degenerate magnetic ground states (antiferromagnetic and ferromagnetic) were predicted. As a consequence of this near-degeneracy in the $C14$ stability range of ${\mathrm{Ti}}_{x}{\mathrm{Fe}}_{1\ensuremath{-}x}$ $(x\ensuremath{\approx}1/3)$ the magnetic properties are strongly correlated with the sublattices' occupation by Ti and Fe. We analyzed the magnetic properties of a series of thin epitaxial films with varying composition in the $C14$ stability range. The temperature- and field-dependent magnetic properties of these samples were determined by dc superc…

On One Identification Problem in Linear Elasticity

1990

In practice we meet problems, when having the solution of partial differential equation, we want to discover parts in the domain of its definition where the solution has some specific properties. In [1] and [2] the problem of identification of a curve φ, lying inside of Ω such that the flux \(\int{_{\varphi }}\frac{\partial u}{\partial n}ds\) is maximal has been studied, where u is the solution of mixed—boundary value problem for Laplacian operator.