Search results for "DOMAIN"
showing 10 items of 2485 documents
Shear strength degradation due to flexural ductility demand in circular RC columns
2014
An analytical model was developed to estimate the shear-strength degradation and the residual capacity of circular reinforced concrete (RC) columns subjected to seismic action. The proposed model is an upgrade of a previously proposed model for axial force $$N$$ , bending moment $$M$$ and shear force $$V$$ ( $$N$$ – $$M$$ – $$V$$ ) interaction domain evaluation for rectangular and circular cross-section RC elements subjected to static loading. The model was extended to the case of circular cross-sections subjected to seismic actions with limitation of the range of variability of the deviation angle between the directions of the stress fields and the crack inclinations, as a function of the …
MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth.
2019
Background Maternal–embryonic crosstalk between the endometrium and the preimplantation embryo is required for normal pregnancy. Our previous results demonstrated that maternal microRNAs secreted into the endometrial fluid, specifically miR-30d, act as a transcriptomic regulator of the preimplantation embryo by the maternal intrauterine environment. Objective To investigate the reproductive and fetal effects of murine miR-30d deficiency at the maternal–embryonic interface according to the origin of its maternal or embryonic default. Study Design A miR-30d knockout murine model was used as the animal model to investigate the impact of maternal and/or embryonic origin of miR-30d deficiency on…
Identification of a plasminogen-binding motif in PAM, a bacterial surface protein.
1995
Surface-associated plasmin(ogen) may contribute to the invasive properties of various cells. Analysis of plasmin(ogen)-binding surface proteins is therefore of interest. The N-terminal variable regions of M-like (ML) proteins from five different group A streptococcal serotypes (33, 41, 52, 53 and 56) exhibiting the plasminogen-binding phenotype were cloned and expressed in Escherichia coli. The recombinant proteins all bound plasminogen with high affinity. The binding involved the kringle domains of plasminogen and was blocked by a lysine analogue, 6-aminohexanoic acid, indicating that lysine residues in the M-like proteins participate in the interaction. Sequence analysis revealed that the…
Gata4 Blocks Somatic Cell Reprogramming By Directly Repressing Nanog
2012
Abstract Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by ectopic expression of the four factors Oct4, Klf4, Sox2, and Myc. Here, we investigated the role of Gata4 in the reprogramming process and present evidence for a negative role of this family of transcription factors in the induction of pluripotency. Coexpression of Gata4 with Oct4, Klf4, and Sox2 with or without Myc in mouse embryonic fibroblasts greatly impaired reprogramming and endogenous Nanog expression. The lack of Nanog upregulation was associated with a blockade in the transition from the initiation phase of reprogramming to the full pluripotent state characteristic of iPS cells. Addition of Nanog …
Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2
2013
Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor with highly undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. The objectives of this study were (i) to characterize CSCs from ex vivo ATC specimens by investigating the expression of several pluripotent stem cell markers, and (ii) to evaluate in vitro drug resistance modifications after specific CSC transcription factor switch-off.In ex vivo experiments, eight formalin-fixed, paraffin-embedded ATC specimens were analyzed by reverse-transcription and real-time quantitative PCR and immunohistochemistry. In in vitro experiments using ATC SW1736 cells, the…
Weighted pointwise Hardy inequalities
2009
We introduce the concept of a visual boundary of a domain �¶ �¼ Rn and show that the weighted Hardy inequality �¶ |u|pd�¶ �A.p C �¶ |�Þu|pd�¶ �A, where d�¶(x) = dist(x, �Ý�¶), holds for all u �¸ C �� 0 (�¶) with exponents �A < �A0 when the visual boundary of �¶ is sufficiently large. Here �A0 = �A0(p, n, �¶) is explicit, essentially sharp, and may even be greater than p . 1, which is the known bound for smooth domains. For instance, in the case of the usual von Koch snowflake domain the sharp bound is shown to be �A0 = p . 2 + �E, with �E = log 4/ log 3. These results are based on new pointwise Hardy inequalities.
Pointwise Hardy inequalities and uniformly fat sets
2008
We prove that it is equivalent for domain in R n \mathbb {R}^n to admit the pointwise p p -Hardy inequality, have uniformly p p -fat complement, or satisfy a uniform inner boundary density condition.
Magneto-optical linear dichroism in threshold photoemission electron microscopy of polycrystalline Fe films.
2000
Magnetic linear dichroism in threshold photoemission has been exploited to obtain magnetic contrast in a photoemission electron microscope using a mercury arc lamp. The dichroism at threshold can be described similar to the magneto-optical Kerr effect in the region of visible light. The asymmetry of electron intensity observed for a 100 nm polycrystalline Fe film on silicon is A=(0.37+/-0.05)%. The asymmetry occurs for the geometry of the transverse Kerr effect. For unpolarized light the asymmetry was about half the value observed for linearly polarized light. Threshold photoemission microscopy has a large potential for high resolution magnetic domain imaging with fast data acquisition.
Application of time domain induced polarization to the mapping of lithotypes in a landfill site
2012
A direct current (DC) resistivity and time domain induced polarization (TDIP) survey was undertaken at a decommissioned landfill site situated in Hørløkke, Denmark, for the purpose of mapping the waste deposits and to discriminate important geological units that control the hydrology of the surrounding area. It is known that both waste deposits and clay have clear signatures in TDIP data, making it possible to enhance the resolution of geological structures compared to DC surveys alone. <br><br> Four DC/TDIP profiles were carried out crossing the landfill, and another seven profiles in the surroundings provide a sufficiently dense coverage of the entire area. The whole dataset w…
A Study on the Propagation of Plane Stress Waves across the Thickness of a Plate by the Method of Analytic Continuation in Time
2004
The interaction of plane tension/compression waves propagating within a plate perpendicularly to its surface is considered. The analytic solution is obtained by a modified method of characteristics for the one-dimensional wave equation used in problems on an impact of a rigid body on the surface of a plate. The displacements, velocities, and stresses in the plate are determined by the edge disturbance caused by the initial velocity and the stationary force field of masses of the striker and the plate. The method of analytic continuation in time put forward allows a stress analysis for an arbitrary time interval by using finite expressions. Contrary to a stress analysis in the frequency doma…