Search results for "DOP"

α-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines

2004

α-Synuclein (α-syn) is a small protein of unknown function that is found aggregated in Lewy bodies, the histopathological hallmark of sporadic Parkinson disease and other synucleinopathies. Mutations in the α-syn gene and a triplication of its gene locus have been identified in early onset familial Parkinson disease. α-Syn turnover can be mediated by the proteasome pathway. A survey of published data may lead to the suggestion that overexpression of α-syn wild type, and/or their variants (A53T and A30P), may produce a decrease in proteasome activity and function, contributing to α-syn aggregation. To investigate the relationship between synuclein expression and proteasome function we have s…

Insect Immune Evasion by Dauer and Nondauer Entomopathogenic Nematodes

2021

The immune response of animals, including insects, is overcome by some parasites. For example, dauer larvae (DL) of the obligate entomopathogenic nematodes (EPNs) Heterorhabditis and Steinernema can invade insects, evade their defenses, and cause death. Although DL were long assumed to be the only infective stage of nematodes, recent reports suggest that L2-L3 larvae of facultative EPNs are also capable of killing insects. There are no studies, to our knowledge, about the role of nonimmunological barriers (the exoskeleton and its openings) in avoiding infection by DL and L2-L3 larvae, or whether these larval stages evade the host immune system in the same way. The objective of this study wa…

Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo

2005

Deregulation of apoptosis signalling is commonly found in cancer and results in resistance to cytotoxic therapies. Immunotherapy is a promising strategy to eliminate resistant cancer cells. The transfer of T-lymphocytes during allogeneic stem cell transplantation is clinically explored to induce a 'graft-versus-tumor' effect (GvT). Cytotoxic T-lymphocytes (CTL), which are major effectors of GvT, eliminate cancer cells by inducing apoptosis via multiple parallel pathways. Here, we study in vitro and in vivo the susceptibility of murine cancer cells engineered to express single antiapoptotic genes to CTL-mediated cytotoxicity. Interestingly, we find that single inhibitors of caspase activatio…

D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

2009

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

Tissue Doppler analysis: does the false negative exist?

2007

Self-cleaning materials active in the visible range based on porphyrin-sensitised titanium dioxide

2016

In the last decades, nanostructured semiconductors played a central role in the material science scene because of their numerous applications spanning from renewable energy to organic/hybrid electronics up to photocatalysis. Titanium dioxide is one of the most used semiconductors because of its low cost, chemical stability, sustainability and versatility. Indeed, it is widely employed as photo-active or charge- transporting material in electronic devices, as photocatalyst in water de-pollution treatments etc.. Remarkably, one of the most interesting application of titanium dioxide consists of the protection and conservation of cultural heritages. Actually, TiO2 photocatalytic properties are…

Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions.

2005

Elicitation of defense reactions in tobacco by cryptogein, triggered a production of active oxygen species (AOS) via the NADPH oxidase, NtrbohD, and an accumulation of beta1din, a defense induced beta-type subunit of 20S proteasome. The proteasome inhibitor, MG132, stimulated this AOS production. Tobacco cells transformed with sense constructs of beta1din showed an inhibition of the AOS production following elicitin treatment, whereas the antisense transformed cells showed a strongly enhanced AOS production. In cells transformed with sense construct of beta1din, the NtrbohD transcripts failed to be induced by cryptogein as observed in control and antisense transformed cells. Conversely, in …

A new species of Hedya Hübner from Iran with proposed rearrangement of some species currently assigned to Metendothenia Diakonoff (Lepidoptera: Tortr…

2011

Hedya tritofa, new species, is described and illustrated based on eleven males and five females collected in northern Iran (Gilan, Mazandaran, and Golestan provinces). Morphology and diagnostic characters of Hedya Hubner, 1825, Metendothenia Diakonoff, 1973, the Olethreutes group of genera, and the Neopotamia group of genera are discussed. We propose the resurrection of the combinations Hedya atropunctana (Zetterstedt, 1840), revised status, and H. separatana (Kearfott, 1907), revised status, and the new combination H. inouei (Kawabe, 1987).

The Tortricidae described by J. C. Fabricius (Lepidoptera)

2011

The identity and nomenclature of the 88 species of Tortricidae (Lepidoptera) described by J. C. Fabricius are reviewed. Type material deposited in the Natural History Museum Denmark is illustrated. Lectotypes for Tinea compositella (Fabricius, 1775), Pyralis rivellana (Fabricius, 1775) and P. strigana (Fabricius, 1775) are designated. Two new synonymies are proposed: Pyralis marmorana (Fabricius, 1798), syn. n., of Ancylis achatana (Denis and Schiffermuller, 1775), and P. rusticana (Fabricius, 1794), syn. n., of Epinotia solandriana (Linnaeus, 1758). In an appendix, the identity and nomenclature of the 49 species of non-Tortricidae described by Fabricius in the genus Pyralis Linnaeus, 1758 …

Description Of A New Species Of Aspinipogon Razowski And Becker, 2010, With The First Reported Female Of The Genus (Lepidoptera: Tortricidae)

2020

AspinipogonRazowski and Becker, 2010 was described as a monotypic genus from Brazil. Aspinipogon samaypatensis Perez Santa-Rita, Valdivia and Baixeras, new species, is described and illustrated from Bolivia. The female of Aspinipogon is reported for the first time, completing the description of the genus. The unusual combination of characters (e.g., wing pattern and venation, male and female genitalia) are discussed in the context of the enigmatic systematic position of Aspinipogon.