Search results for "DOP"
showing 10 items of 4870 documents
T-Cell Vaccination in Patients with Nickel Allergic Contact Dermatitis
1995
Bērnu tiesības zināt savu izcelsmi
2021
Bērna tiesības zināt savu izcelsmi ir samērā jauns institūts, kurš starptautiskajā mērogā tiek daudz un dažkārt pretrunīgi vērtēts. Eiropas Cilvēktiesību tiesas un Latvijas tiesu prakse parāda, ka ne vienmēr ir skaidrs, kādā veidā bērnam ir jānodrošina viņa tiesības zināt savu izcelšanos un kā ir risināmas sadursmes starp kolidējošām tiesībām un citu personu interesēm, taču kopumā tiesību zināt savu izcelšanos izpratne laika gaitā ir attīstījusies un mainījusies. Vienlaikus neskaidrs paliek jautājums, vai Latvijas nacionālais normatīvais regulējums ir šai izpratnei atbilstošs? Maģistra darbā ir apskatīta bērnu tiesību zināt savu izcelšanos vēsturiskā attīstība, saturs, tostarp šo tiesību ne…
Bērnu interešu aizsardzība adopcijā.
2020
Autore, izstrādājot darbu, pievēršas šī institūta problēmjautājumiem un normatīvo tiesību aktu nepilnībām. Bakalaura darbs balstās uz pastāvošās nacionālās un starptautiskās prakses analīzi un statistikas datiem, kā arī uz valsts un starptautisko iestāžu lomu analīzi šo jautājumu ietvaros. Bakalaura darba mērķis ir piedāvāt priekšlikumus, lai novērstu normatīvo tiesību aktu trūkumus un vērstu sabiedrības uzmanību uz adopciju kā vienu no ģimenes veidošanas iespējām. Bakalaura darba rezultātā tika izstrādāti jauni priekšlikumi, kas vērsti uz bērnu interešu nodrošināšanu un aizsardzību.
Adopcija
2016
Bakalaura darba tēma ir Adopcija. Autore bakalaura darba tēmas izvēlē un izstrādē balstījusies uz to, adopcijas institūta attīstība un ar to saistītās problēmas plašākā sabiedrībā nav ieguvušas īpašu aktualitāti, tomēr no sabiedrības interešu viedokļa un to cilvēku motivācijas dēļ, kuri gatavojas kļūt par adoptētājiem adopcijas jautājuma sakārtošanai valstī ir milzīga nozīme. Bakalaura darba mērķis ir izskaidrot un pamatot kādēļ adopcijas procesam ir nepieciešama tā specifika un noteiktais ilgums. Autore uzskata, ka ir veiksmīgi realizējusi mērķus, kuru realizācija bija paredzēta bakalaura darba izveides procesā. Atslēgvārdi : Adopcija, adopcijas process, bērna interešu aizsardzība, ģimene,…
Synthesis, structural and luminescent properties of Mn-doped calcium pyrophosphate (Ca2P2O7) polymorphs
2022
The study was partially funded by the Swedish Research Council FORMAS project “Utilization of solid inorganic waste from the aquaculture industry as wood reinforcement material for flame retardancy” (grant no. 2018-01198). Vilnius University is highly acknowledged for financial support from the Science Promotion Foundation (MSF-JM-5/2021). This project has also received funding from European Social Fund (project No 09.3.3-LMT-K-712-19-0069) under grant agreement with the Research Council of Lithuania (LMTLT). The authors acknowledge the Center of Spectroscopic Characterization of Materials and Electronic/Molecular Processes ("SPECTROVERSUM" www.spectroversum.ff.vu.lt ) at the Lithuanian Nat…
Immunotherapy targeting colon cancer stem cells
2010
In the last 10 years, cancer stem cells have interested the scientific community because this small tumorigenic population is also associated with tumor progression in human patients and specific targeting of cancer stem cells could be a strategy to eradicate cancers currently resistant to conventional therapy. Clinical studies have recently demonstrated that adding immune therapy to chemotherapy has survival benefits in comparison with chemotherapy alone that can sensitize tumors to immune cell-mediated killing (e.g., increasing sensitivity of tumor cells to subsequent cytotoxicity by T cells via upregulation of death receptors DR5 and Fas). However, loss of MHC molecules is often observe…
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…
Asymptomatic carotid lesions add to cardiovascular risk prediction.
2010
AIM To show that subclinical atherosclerosis (subclinical-ATS) of carotid arteries [intima-media thickness (IMT) or asymptomatic carotid plaque (ACP)], may provide additional information for risk stratification, in asymptomatic patients, aged greater than 45 years, with a cluster of risk factors (RFs). METHODS AND RESULTS We studied 558 asymptomatic patients (235 males). RFs for atherosclerosis were assessed and the 10-year-risk was calculated according to the Italian risk score. Doppler ultrasound of carotid arteries identified the presence of IMT greater than 0.9 mm in 183 patients and ACP in 147 patients. One hundred and fifty-three patients developed cerebrovascular or cardiovascular (C…
Prognostic Impact of let-7e MicroRNA and Its Target Genes in Localized High-Risk Intestinal GIST: A Spanish Group for Research on Sarcoma (GEIS) Study
2020
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between relapsed and non-relapsed patient samples, which were validated in the expansion set, by qRT-PCR. RT2 Profiler PCR Array was used for the screening of let-7e targets. Expression levels were co…
Cation Diffusion and Segregation at the Interface between Samarium-Doped Ceria and LSCF or LSFCu Cathodes Investigated with X-ray Microspectroscopy
2017
The chemical compatibility between electrolytes and electrodes is an extremely important aspect governing the overall impedance of solid-oxide cells. Because these devices work at elevated temperatures, they are especially prone to cation interdiffusion between the cell components, possibly resulting in secondary insulating phases. In this work, we applied X-ray microspectroscopy to study the interface between a samarium-doped ceria (SDC) electrolyte and lanthanum ferrite cathodes (La0.4Sr0.6Fe0.8Cu0.2O3(LSFCu); La0.9Sr0.1Fe0.85Co0.15O3(LSCF)), at a submicrometric level. This technique allows to combine the information about the diffusion profiles of cations on the scale of several micromet…