Search results for "DOP"

Attēla kvalitāti ietekmējošie faktori iegurņa datortomogrāfijas izmeklējumos pacientiem ar veiktu gūžas locītavu endoprotezēšanu

2020

Bakalaura darba tēma- ’’Attēla kvalitāti ietekmējošie faktori iegurņa Datortomogrāfijas izmeklējumos pacientiem ar veiktu gūžas locītavu endoprotezēšanu.” Tēmas aktualitāti nosaka protokola pielietošana datortomogrāfijā pacientiem ar gūžas locītavu endoprotezēšanu. Metālisko artefaktu dēļ, iegūtie izmeklējumi bieži ir attēldiagnostiski nekvalitatīvi, tapēc ir svarīgi, lai izmeklējuma protokols būtu maksimāli kvalitatīvs un pielāgots pacienta ķermeņa īpatnībam, metāliskām protēzēm un datortomografijas aparāta īpatnībām, kas tadā veidā ļauj uzlabot iegūto izmeklējuma attēlu. Darba mērķis ir izvērtēt datortomogrāfijas protokolu īpatnības dažādos literatūras avotos un analizēt iespējamos attēla…

Relativiert der Zufall die Rationalitätskategorie? Gewissheit, Wahrscheinlichkeit und der Relativismus

2016

Behaviours and Beliefs Related to Whistleblowing Against Doping in Sport: A Cross-National Study.

2022

BackgroundWhistleblowing has been recognized as an important deterrent of doping in elite competitive sport. The present study examined athletes’ knowledge of external whistleblowing channels and on how and where to report doping misconduct, perceived trust in different whistleblowing reporting channels, whistleblowing behaviour and athletes’ reasons for reporting (or not) doping misconduct.MethodsAthletes from Greece (n = 480), the Russian Federation (n = 512) and the United Kingdom (n = 171) completed a structured questionnaire on demographics, knowledge of different whistleblowing channels, perceived trust in internal and external whistleblowing channels, past whistleblowing behaviour an…

Lezioni di Diritto Sportivo, Quinta edizione

2020

Questa quinta edizione dell’opera è frutto del lavoro di integrale revisione e aggiornamento della quarta, edita nel 2018. Essa dà conto in particolare, tra l’altro, delle sostanziali modifiche introdotte dalla Legge di Stabilità 2019 con riguardo all’assetto organizzativo del CONI e alla soppressa CONI Servizi S.p.A., nonché alla modifica dei criteri di riparto dei proventi della negoziazione dei diritti audiovisivi. L’aggiornamento concerne, altresì, le modifiche apportate dal D.L. n. 87/2018 (c.d. Decreto Dignità) alla normativa sulle società sportive dilettantistiche e relativa disciplina fiscale, nonché degli aggiornamenti alla disciplina sull’agente sportivo in base al Regolamento CON…

El Doppler de la arteria vertebral como alternativa al Doppler de la arteria cerebral media en el diagnóstico de la restricción del crecimiento fetal

2017

En el feto, la irrigación cerebral proviene fundamentalmente de dos ramas, la arteria vertebral y la arteria carótida interna, que formarán posteriormente el polígono de Willis. Por una parte, la arteria vertebral que es, generalmente, la primera rama y la de mayor tamaño de la arteria subclavia. Ésta irriga toda la parte posterior del cerebro. Por otro lado, la arteria carótida interna irriga la parte anterior del cerebro y es de mayor calibre que la arteria carótida externa, ambas procedentes de la arteria carótida común. La arteria carótida interna y su mayor rama, la arteria cerebral media (ACM), ha sido ampliamente estudiada debido a que está implicada en el mecanismo de “brain-sparing…

Regulation of immune response in post-operative endophthalmitis

2011

Regulation of immune response in post-operative endophthalmitis. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)

Quality culture boosts agile transformation : Action research in a business‐to‐business software business

2023

Agile methodologies are sometimes adopted, with the assumption that benefits can be attained by only using a set of best practices, which can sometimes work to a degree. In this paper, a case is discussed where a software-producing organization of seven teams achieved significant improvements. The goal of the research was to answer two questions: how an already agile organization could improve its performance further and what is the impact of promoting quality aspects? The questions were answered by implementing interventions based on prior literature and data emerging from semi-structured interviews. The context was an established business with a complex revenue stream structure, meaning t…

[Detection of extra-articular soft-tissue involvement in rheumatoid arthritis: value of color-coded Doppler sonography]

2002

A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

2015

AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

2016

Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L. Novel rhodesain inhibitors were developed by combining an enantiomeri…