Search results for "DOPAMINE UPTAKE"

showing 3 items of 33 documents

Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents.

2017

Introduction Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. Aim The aim of this work was to review the most important data of the literature in the last 10 years about the effects of cocaine and MDMA on inhibitory avoidance and object recognition tests in rodents. Development: The object recognition and the inhibitory avoidance tests are popular procedures used to assess different types of memory. We compare th…

medicine.medical_specialtyMDMACognitive Neurosciencemedia_common.quotation_subjectN-Methyl-34-methylenedioxyamphetamineEcstasyInvestigación médicaEnsayos clínicosExperimental and Cognitive PsychologyRodentiaPublic problemInhibitory postsynaptic potential03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineCocaineDopamine Uptake Inhibitorsmental disordersmedicineAvoidance LearningAnimalsDrogasPsychiatrymedia_commonMemory DisordersAdrenergic Uptake InhibitorsBehavior AnimalAddictionMDMACognitionRecognition PsychologyInhibitory avoidanceAbstinenceDifferential effects030227 psychiatryEfectos fisiológicosPsychologyEstupefaciente030217 neurology & neurosurgerymedicine.drugNeurobiology of learning and memory
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Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.

2009

The impact of serotonergic neurotransmission on brain dopaminergic pathways has substantial relevance to many neuropsychiatric disorders. A particularly prominent role has been ascribed to the inhibitory effects of serotonin 2C receptor (5-HT2CR) activation on physiology and behavior mediated by the mesolimbic dopaminergic pathway, particularly in the terminal region of the nucleus accumbens. The influence of this receptor subtype on functions mediated by the nigrostriatal dopaminergic pathway is less clear. Here we report that a null mutation eliminating expression of 5-HT2CRs produces marked alterations in the activity and functional output of this pathway. 5-HT2CR mutant mice displayed i…

medicine.medical_specialtySerotoninDopamineDopamine AgentsPhysiologySubstantia nigraStriatumBiologySettore BIO/09 - FisiologiaPiperazinesArticleMiceDopamine receptor D1Dopamine Uptake InhibitorsDopamineDopamine receptor D2Internal medicineNeural PathwaysmedicineReceptor Serotonin 5-HT2CAnimalsNeuronsBehavior AnimalPars compactaGeneral Neuroscience5-HT2CR substantia nigra pars compacta dorsal striatum dopamine extracellular recording in vivo patch clamp recording microdialysis Locomotor activity Stereotypic behaviorDopaminergicNeurobehavioral disordersBenzazepinesGroomingCorpus StriatumElectrophysiologyMice Inbred C57BLSubstantia NigraAmphetamineEndocrinologymedicine.anatomical_structureDopaminergic pathwaysDopamine AgonistsMutationAutoradiographyStereotyped BehaviorNeuroscienceLocomotionmedicine.drugThe Journal of neuroscience : the official journal of the Society for Neuroscience
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Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects.

2021

Using the social defeat (SD) model, numerous studies have shown that stressed mice display an enhanced response to the motivational effects of cocaine in the self-administration (SA) and conditioned-place preference (CPP) paradigms. However, not all subjects exposed to stress express its harmful effects. Some are particularly susceptible to the deleterious effects of repeated SD, while resilient mice successfully cope with stressful experiences and display adjusted psychological functioning after stress. Vulnerability to develop stress-related disorders, such as depression, has been linked to coping strategies and more recently to individual differences in the immune system. However, no stu…

medicine.medical_treatmentHippocampusStriatumHippocampusSocial defeat03 medical and health sciences0302 clinical medicineImmune systemNeuroinflammationCocaineDopamine Uptake InhibitorsSocial defeatConditioning PsychologicalMedicineAnimalsCX3CL1CytokineBiological PsychiatryNeuroinflammationPharmacologySocial stressResilienceBehavior Animalbusiness.industryChemokine CX3CL1Corpus Striatum030227 psychiatryPsicobiologiaCytokineChemokineSusceptibilityImmunologyCytokinesbusinessStress PsychologicalProgress in neuro-psychopharmacologybiological psychiatry
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