Search results for "DOT"
showing 10 items of 5147 documents
Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes
2020
Abstract Tobacco smoking is a leading cause of non-communicable disease globally and is a major risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by the World Health Organizations (WHO) indicate that in the last two decades global tobacco use has significantly dropped, which was largely driven by decreased numbers of female smokers. Despite such advances, the use of e-cigarettes and waterpipes (shisha, hookah, narghile) is an emerging trend, especially among younger generations. There is growing body of evidence that e-cigarettes are not a harm-free alternative to tobacco cigarettes and there is considerable debate as to whether e-cigarettes are saving …
Digestive disorders and Intestinal microbiota
2018
In the last decade, a barge body of scientific literature has suggested that specific alterations of the gut microbiota may be associated with ther development and clinical course of several gastrointestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, gastrointestinal cancer and Clostridium difficile infection. These alterations are often referred to as “dysbiosis”, a generic term designing reduction of gut microbiota biodiversity and alterations in its composition. Here, we provide a synthetic overview of the key concepts on the relationship between intestinal microbiota and gastrointestinal diseases, focusing on the translation of these concep…
I vincoli organizzativi alla formazione dei sistemi turistici locali: i Club di prodotto
2010
Agli inizi dello sviluppo del turismo, fare turismo significava essenzialmente trasferirsi per un periodo di tempo più o meno lungo non superiore ad un anno in un luogo diverso da quello da quello abituale e soddisfare l’esigenza in un luogo gradevole e funzionale e con poche esigenze essenziali (fare il bagno al mare, passeggiare in un luogo diverso dall’abituale, sciare in montagna, ecc.). Oggi nel fare turismo è sempre più importante il “cosa fare” e il “come farlo” e la località tende quindi ad essere valutata e prescelta in ragione della capacità di garantire una soddisfazione turistica non solo attrattiva, che convince il turista a muoversi verso di essa, ma occorre garantire servizi,…
Endovascular treatment of chronic cerebro spinal venous insufficiency in patients with multiple sclerosis modifies circulating markers of endothelial…
2014
Quo vadis? : pięćdziesiąt lat kodeksu cywilnego
2015
Asistencia, matrimonio e inserción social: "La loable confraría e almoina de les òrfenes a maridar"
1993
La ayuda a la constitución de la dote de las muchachas fue una forma de asistencia muy extendida en el ámbito urbano bajomedieval. En Valencia surgió una cofradía cuyo objetivo inicial fue abordar este tipo concreto de caridad. Pero no es la descripción de una fórmula asistencial lo que más interesa al acercarse a su organización y su funcionamiento; resulta mucho más revelador analizar el modelo de matrimonio que subyace tras el desarrollo de estas iniciativas, así como los fines reales que movieron a los ciudadanos relevantes de la Valencia de inicios del siglo XV a implicarse en tal tarea.
La Ermita del Roser de Vilallonga del Camp: notas históricas
1984
ANALISIS DE LA HISTORIA DE UNA ERMITA RURAL, LA DEL ROSER, EN EL CAMPO DE TARRAGONA, A TRAVES DE LA DOCUMENTACION DE LOS ARCHIVOS MUNICIPAL Y PARROQUIAL DE VILALLONGA. A TRAVES DEL MISMO SE DETECTAN TAMBIEN LAS VICISITUDES DEL PUEBLO DURANTE LA EPOCA MODERNA Y CONTEMPORANEA. SE INCLUYE EN APENDICE UNA LINEA DE PARROCOS Y OTRA DE ERMITAÑOS
2013
The amyloid-β42 (Aβ42) peptide plays a crucial role in the pathogenesis of Alzheimer’s disease (AD), the most common neurodegenerative disorder affecting the elderly. Over the past years, several approaches and compounds developed for the treatment of AD have failed in clinical studies, likely in part due to their low penetration of the blood–brain barrier (BBB). Since nanotechnology-based strategies offer new possibilities for the delivery of drugs to the brain, this technique is studied intensively for the treatment of AD and other neurological disorders. The Aβ42 lowering drug flurbiprofen was embedded in polylactide (PLA) nanoparticles by emulsification-diffusion technique and their pot…
Hypoxia-induced reduction of sVEGFR-2 levels in human colonic microvascular endothelial cells in vitro: Comparative study with HUVEC.
2008
The functionality of large-vessel endothelial cells, such as human umbilical vein endothelial cells (HUVEC), may differ significantly from that in the microvasculature. We established a method for the isolation of human colonic microvascular endothelial cells (HCMEC). Since colonic diseases are often accompanied by hypoxia we examined its effects on HCMEC of five individuals in comparison with HUVEC, with respect to the secretion of the soluble form of the two important vascular endothelial growth factor (VEGF) receptors, VEGFR-1 and 2. After dissociation by dispase/collagenase of mucosal and submucosal tissue obtained from normal adult colon, HCMEC were isolated using CD31-coated magnetic …
Ruddlesden-Popper Hybrid Lead Bromide Perovskite Nanosheets of Phase Pure n=2: Stabilized Colloids Stored in the Solid State.
2021
Ruddlesden-Popper lead halide perovskite (RP-LHP) nano-nanostructures can be regarded as self-assembled quantum wells or superlattices of 3D perovskites with an intrinsic quantum well thickness of a single or a few (n=2-4) lead halide layers; the quantum wells are separated by organic layers. They can be scaled down to a single quantum well dimension. Here, the preparation of highly (photo)chemical and colloidal stable hybrid LHP nanosheets (NSs) of ca. 7.4 μm lateral size and 2.5 nm quantum well height (thereby presenting a deep blue emission at ca. 440 nm), is reported for the first time. The NSs are close-lying and they even interconnect when deposited on a substrate. Their synthesis is …