Search results for "DPH"
showing 10 items of 361 documents
Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease
2014
Abstract Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. In this study, I have reviewed observed associations between folate intake, as well as its blood levels, and BC. The purpose of this review is to analyse the role of folate and the two SNPs associated with reduced enzyme activity in B…
PKP-020 Impact of nadph oxidase functional polymorphisms in acute myeloid leukaemia induction chemotherapy
2016
Background NADPH oxidase, a key mediator of oxidative cardiac damage and remodelling, modulates anthracycline clinical cardiotoxicity. Purpose Single nucleotide polymorphisms (SNPs) of NADPH oxidase genes could lead to interindividual differences in treatment outcome in acute myeloid leukaemia (AML) patients. Material and methods The main three NADPH oxidase polymorphisms (CYBA:rs4673, NCF4:rs1883112 and RAC2:rs13058338) were evaluated in 225 adult patients at the initial diagnosis of AML using a mass spectrometry based multiplex genotyping assay (Sequenom). All patients received induction chemotherapy consisting of idarubicin plus cytarabine (PETHEMA 99, 2007 and 2010 trials). The efficacy…
Active oxygen species production in tobacco cells elicited by cryptogein*
1997
We analyse the relationship between active oxygen species (AOS) production and pH changes induced in tobacco cells by cryptogein, a fungal proteinaceous elicitor of defence mechanisms in plants. When tobacco cells were treated with cryptogein, an intracellular acidification, an alkalinization of the extracellular medium and a transient burst of AOS (H 2 O 2 ) were observed. Treatment of elicited cells with either diphenyleneiodonium (DPI), an inhibitor of the neutrophil NADPH oxidase, or Tiron, which scavenges O2 - , abolished AOS production. These data suggest the involvement of a NADPH oxidase-like enzyme leading to H 2 O 2 production through O 2 - dismutation. Although H 2 O 2 production…
"Table 7" of "Measurement of angular correlations in Drell-Yan lepton pairs to probe Z/gamma* boson transverse momentum at sqrt(s)=7 TeV with the ATL…
2015
The combined normalised differential PHI* distributions at the Born level in the different rapidity ranges.
"Table 50" of "Study of jets produced in association with a W boson in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector"
2014
The predicted W+jets cross section as a function of the |phi(first jet)-phi(second jet)| for jet multiplicites >= 2 and jet PT > 30 GeV.
"Table 100" of "Study of jets produced in association with a W boson in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector"
2014
The predicted W+jets cross section as a function of the |phi(first jet)-phi(second jet)| for jet multiplicites >= 2 and jet PT > 20 GeV.
"Table 25" of "Study of jets produced in association with a W boson in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector"
2014
The measured W+jets cross section as a function of the |phi(first jet)-phi(second jet)| for jet multiplicites >= 2 and jet PT > 30 GeV shown for "Born" leptons and for QED corrected "dressed" leptons.
"Table 75" of "Study of jets produced in association with a W boson in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector"
2014
The measured W+jets cross section as a function of the |phi(first jet)-phi(second jet)| for jet multiplicites >= 2 and jet PT > 20 GeV shown for "Born" leptons and for QED corrected "dressed" leptons.
Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description
1994
The distribution and abundance of nitric oxide synthase (NOS)-containing neurons and their terminals in the gastrointestinal tract of the guinea-pig were examined in detail using NADPH diaphorase histochemistry and NOS immunohistochemistry. NOS-containing cell bodies were found in the myenteric plexus throughout the gastrointestinal tract and in the submucous plexus of the stomach, colon and rectum. NOS-containing neurons comprised between 12% (in the duodenum) and 54% (in the esophagus) of total myenteric neurons. In the ileum, NOS neurons represented 19% of total myenteric neurons. Most of the NOS neurons throughout the gastrointestinal tract possessed lamellar dendrites and a single axon…
Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling
2011
Nitric oxide (NO) produced by the endothelium is an important protective molecule in the vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all NOS isoforms, functional eNOS transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH), via the flavins flavin adenine dinucleotide and flavin mononucleotide in the carboxy-terminal reductase domain, to the heme in the amino-terminal oxygenase domain. Here, the substrate L-arginine is oxidized to L-citrulline and NO. Cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolaemia or cigarette smoking reduce bioactive NO. These risk factors lead to an enhanced productio…