6533b858fe1ef96bd12b638c

RESEARCH PRODUCT

Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease

Valentina Bravatà

subject

Oncologymedicine.medical_specialtyBreast NeoplasmsSingle-nucleotide polymorphismDiseasePolymorphism Single NucleotideFolic AcidBreast cancerRisk FactorsInternal medicinemedicineHumansMthfr c677tFolate intakeBreast cancer; MTHFR; MTHFR A1298C; MTHFR C677TMethylenetetrahydrofolate Reductase (NADPH2)Genetic associationGeneticsBreast cancer MTHFR MTHFR A1298C MTHFR C677Tbiologybusiness.industrymedicine.diseaseMethylenetetrahydrofolate reductaseMutationbiology.proteinFemalebusinessFood Science

description

Abstract Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. In this study, I have reviewed observed associations between folate intake, as well as its blood levels, and BC. The purpose of this review is to analyse the role of folate and the two SNPs associated with reduced enzyme activity in BC. I explored the most relevant and updated work that emphasises positive and negative associations among these variables. My findings indicate that no definitive conclusions can be drawn from the studies on this topic. However, this manuscript highlights variables that could be useful to explore in further association analyses.

yearjournalcountryeditionlanguage
2014-10-17
10.3109/09637486.2014.959896http://hdl.handle.net/10447/100601