Search results for "DSM-V"
showing 3 items of 3 documents
Towards a meta-method for the engineering of situational evaluation methods for domain-specific modeling tools
2015
Sovellusaluemallinnus (Domain-Specific Modeling, DSM) on eräs ohjelmistotuotannon lähestymistavoista, jossa sovelluskehityksen abstraktiotasoa nostetaan ohjelmoinnista sovellusaluekeskeiseen mallinnukseen. DSM mahdollistaa sovelluskehityksen automatisoinnin erityisesti kapeilla ja vakiintuneilla sovellusalueilla, joiden käsitteet, säännöt ja merkitykset soveltuvat DSM-kielten konstruktioiksi. DSM-välineet tarjoavat työkaluja DSM-kielten määrittelyyn ja käyttöön sekä sovellusmallien transformaatioihin. Teollisuudessa DSM-välineiden arviointeja tehdään tyypillisesti välinehankintojen valmistelun yhteydessä. Arviointeja suoritetaan myös tieteellisen tutkimuksen näkökulmasta. Arviointitulosten …
Understanding Addiction Using Animal Models
2019
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an extraordinary global economic impact. Despite decades of research, the options available to treat addiction are often ineffective because our rudimentary understanding of drug-induced pathology in brain circuits and synaptic physiology inhibits the rational design of successful therapies. This understanding will arise first from animal models of addiction where experimentation at the level of circuits and molecular biology is possible. We will review the most common preclinical models of addictive behavior and discuss the advantages and disadvantages of each. This includes non-contingent models in whi…
A common biological basis of obesity and nicotine addiction
2013
Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked …