6533b7ddfe1ef96bd1273e55

RESEARCH PRODUCT

A common biological basis of obesity and nicotine addiction

Peter KovacsAngela DöringFrank GellerLenka ForetovaDana MatesPaul M. RidkerFrancesco MauriMark J. CaulfieldNora FranceschiniNeonilia Szeszenia-dabrowskaToshiko TanakaPagona LagiouJennifer E. HuffmanPaul ScheetGudmar ThorleifssonJacqueline M. VinkNicole VogelzangsIda SurakkaIda SurakkaJeffrey R. GulcherUlrich JohnVeikko SalomaaEco J. C. De GeusHakon HakonarsonAnne BartonLuigi BarzanH.-erich WichmannAnneli PoutaPeter VollenweiderKristina KjærheimJed E. RoseRuth J. F. LoosSusanne LucaeDanielle PosthumaHenning TiemeierFangyi GuFangyi GuMark I. MccarthyMark I. MccarthyUnnur StyrkarsdottirJames MckayTalin HarituniansMartin PreisigOlle MelanderXavier CastellsaguéWilliam H. MatthaiPiera Angelica MerliniDaniel I. ChasmanMichael StumvollOzren PolasekNilesh J. SamaniSøren BesenbacherSøren BesenbacherJane WorthingtonDaniel F. GudbjartssonAlistair S. HallAntonio AgudoKeith MatthewsGonçalo R. AbecasisJaana LaitinenNorbert DahmenNorbert DahmenRobert W. MahleyMari NelisMari NelisInga ProkopenkoInga ProkopenkoAnke TönjesIris H GudjonsdottirJoshua W. KnowlesJing Hua ZhaoJouke-jan HottengaVincent MooserJack SatsangiCristina CanovaStephen P. FortmannHreinn StefanssonManuela UdaT. BruecklMary Susan BurnettMichael BoehnkeVeronique VitartPhilip J. BarterRuth McphersonRuth McphersonBenjamin F. VoightBenjamin F. VoightPatrick F. SullivanPier Mannuccio MannucciMichael WittigKari StefanssonKari StefanssonLowell F. SatlerEric BoerwinkleBenjamin J. WrightBen A. OostraJohn StraussStefania BandinelliS. HorstmannJonathan MarchiniJonathan MarchiniSimone BenhamouStephen E. EpsteinRajesh RawalVladimir JanoutMiles ParkesLiming QuYuri MilaneschiPeter AlmgrenKaisu KeskitaloMatti IsohanniMatti IsohanniDan RujescuJohn P. A. IoannidisJohn P. A. IoannidisPeter RudnaiStefan WalterDiego ArdissinoJohn B. VincentLeif GroopKent D. TaylorChristopher J. O'donnellChristopher W. KnouffDavid I. ConwayThomas QuertermousJoseph M. LindsayStephen M. SchwartzTariq AhmedJolanta LissowskaEvan L. ThackerIgor RudanSreekumar G. PillaiJanet Audrain-mcgovernDaniel LevyS. KathiresanS. KathiresanTimothy M. FraylingBrenda W.j.h. PenninxShen Huei-yiShen Huei-yiJohannes H. SmitJohannes H. SmitGonneke WillemsenHenry VölzkeJohn R. B. PerryFederica TozziRoberto ElosuaDevin AbsherG B WaltersAugusto D. PichardStephen J. ChanockStephen J. ChanockKatja K.h. AbenAnna-liisa HartikainenAnna-liisa HartikainenMaria KrestyaninovaIvana HolcatovaTim D. SpectorMing D. LiXiangjun XiaoBarbara McknightHans J. GrabeMartin Den HeijerCaroline HaywardUnnur ThorsteinsdottirUnnur ThorsteinsdottirDouglas F. LevinsonClaes LadenvallRobert L. WilenskyDanyu LinDanyu LinNicole SoranzoNicole SoranzoLefkos T. MiddletonJason S. LiuWade H. BerrettiniLaura M. ThorntonMuredach P. ReillyJack M. GuralnikRon WaksmanPer BakkeAlan F. WrightAndre FrankeThorgeir E. ThorgeirssonBarbara NitzAnthony J. BalmforthJaspal S. KoonerGavin LucasEsther H. LipsHelena FurbergAlbert HofmanPatrick SulemAstrid PetersmannIvana KolcicJaakko TuomilehtoJaakko TuomilehtoLorenzo RichiardiPablo V. GejmanClaire J. StevesThorarinn TyrfingssonYurii S. AulchenkoBrendan M. EverettBrendan M. EverettBrendan M. EverettAriana ZnaorMaxine AllenThorunn RafnarMark LathropMark LathropReedik MägiReedik MägiReedik MägiKenneth M. KentM. PerolaM. PerolaNicholas J. WarehamDaniel J. RaderJohn R. ThompsonSarah R. PreisPeter KraftCaryn LermanHogni OskarssonAlan R. SandersAlexander TeumerXin YuanCornelia M. Van DuijnSamuli RipattiSamuli RipattiAndré G. UitterlindenCarl A. AndersonMartin FarrallKay-tee KhawJoachim HeinrichHeather M. StringhamBruce M. PsatyBruce M. PsatyJaakko KaprioJaakko KaprioValgerdur SteinthorsdottirSteve EyreJames F. WilsonDavid J. HunterDavid J. HunterJohannes KettunenWendy ThomsonAntero KesäniemiKaren L. MohlkeChristian GiegerTatiana V. MacfarlaneJubao DuanAnne FarmerClyde FrancksJoshua C. BisHarry CampbellPierandrea MugliaAndres MetspaluAndres MetspaluDawn M. WaterworthRamachandran S. VasanHermine H. MaesDavid ZaridzeLuisa BernardinelliLuisa BernardinelliVladimir BenckoMassimo ManginoLambertus A. KiemeneySolveig GretarsdottirTõnu EskoTõnu EskoAnne U. JacksonClaire M. HealyScott M. GrundyDavid St ClairCurt D. FurbergMingyao LiPeter McguffinChristopher G. MathewDavid AltshulerDavid AltshulerDorret I. BoomsmaSusan CampbellJianxin ShiNajaf AminJames L. KennedyAna M. ValdesAnna F. DominiczakThemistocles L. AssimesSusan E. HankinsonInês BarrosoMarjo-riitta JärvelinMarjo-riitta JärvelinGuillaume ParéGuillaume ParéJoe DevaneyAntonio TerraccianoDavid SchlessingerPaul BrennanShih-jen HwangLuigi FerrucciRay LowryJennifer DackorEleonora FabianovaLina ZgagaEmelia J. BenjaminFabio BusoneroSarah H. WildPatricia B. MunroeJohn C. ChambersCarlos IribarrenMarcus IsingYunjung KimRichard O. DayAmund GulsvikGérard WaeberClaudia LaminaClaudia LaminaArne Schäfer

subject

obesityFOOD-INTAKETAG Consortiummedicine.medical_treatmentOxford-GSK ConsortiumLOCIIcelandAetiology screening and detection [ONCOL 5]VARIANTS3124 Neurology and psychiatryNicotine0302 clinical medicineDEPENDENCE030212 general & internal medicineAge of OnsetENGAGE consortiumPOPULATIONAddiction; Body Mass Index; Nicotine dependence; Smokingmedia_commonPsychiatry2. Zero hunger0303 health scienceseducation.field_of_studyASSOCIATIONTobacco Use DisorderDSM-VCANCER3142 Public health care science environmental and occupational health3. Good healthPsychiatry and Mental healthMeta-analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingOriginal ArticleaddictionLife Sciences & Biomedicinemedicine.drugmedicine.medical_specialtymedia_common.quotation_subjectPopulationbody mass indexPolymorphism Single Nucleotidesmoking03 medical and health sciencesCellular and Molecular NeuroscienceSDG 3 - Good Health and Well-beingInternal medicinemedicineHumansSMOKING-BEHAVIORnicotine dependencePsychiatryeducationBiological PsychiatryMolecular epidemiology Aetiology screening and detection [NCEBP 1]030304 developmental biologyScience & Technologybusiness.industryAddictionAppetitemedicine.diseaseObesityBODY-MASS INDEXBehavior AddictiveEndocrinologySmoking cessationbusinessBody mass index

description

Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 x 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 x 10(-5)) and CPD (P=9.3 x 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.

yearjournalcountryeditionlanguage
2013-10-01Translational Psychiatry
10.1038/tp.2013.81https://doi.org/10.1038/tp.2013.81