0000000000201171

AUTHOR

Ana M. Valdes

showing 4 related works from this author

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

2011

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…

Malenivelrikkomedicine.medical_specialtygenetiikkaBiomedical EngineeringMEDLINEdiagnostiset kriteeritOsteoarthritisbehavioral disciplines and activitiesArticleCohort Studies03 medical and health sciencesRotterdam Study0302 clinical medicineRheumatologyInternal medicineTREATOAOsteoarthritismedicinePrevalenceGeneticsHumansOrthopedics and Sports Medicine030304 developmental biologyRheumatology and Autoimmunity2. Zero hunger030203 arthritis & rheumatology0303 health sciencesAnalysis of Varianceperinnöllisyystiedebusiness.industryCase-control studyDefinitionReference Standardsmedicine.diseaseGenetics Osteoarthritis Phenotype Definition TREATOA genome-wide association radiographic hip osteoarthritis bone-mineral density knee osteoarthritis hand osteoarthritis osteoporotic fractures general-population joint involvement risk-factors susceptibilityRheumatology3. Good healthPhenotypeCase-Control Studiesdiagnostic criteriaCohortPhysical therapyFemalebusinessBody mass indexCohort study
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A common biological basis of obesity and nicotine addiction

2013

Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked …

obesityFOOD-INTAKETAG Consortiummedicine.medical_treatmentOxford-GSK ConsortiumLOCIIcelandAetiology screening and detection [ONCOL 5]VARIANTS3124 Neurology and psychiatryNicotine0302 clinical medicineDEPENDENCE030212 general & internal medicineAge of OnsetENGAGE consortiumPOPULATIONAddiction; Body Mass Index; Nicotine dependence; Smokingmedia_commonPsychiatry2. Zero hunger0303 health scienceseducation.field_of_studyASSOCIATIONTobacco Use DisorderDSM-VCANCER3142 Public health care science environmental and occupational health3. Good healthPsychiatry and Mental healthMeta-analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingOriginal ArticleaddictionLife Sciences & Biomedicinemedicine.drugmedicine.medical_specialtymedia_common.quotation_subjectPopulationbody mass indexPolymorphism Single Nucleotidesmoking03 medical and health sciencesCellular and Molecular NeuroscienceSDG 3 - Good Health and Well-beingInternal medicinemedicineHumansSMOKING-BEHAVIORnicotine dependencePsychiatryeducationBiological PsychiatryMolecular epidemiology Aetiology screening and detection [NCEBP 1]030304 developmental biologyScience & Technologybusiness.industryAddictionAppetitemedicine.diseaseObesityBODY-MASS INDEXBehavior AddictiveEndocrinologySmoking cessationbusinessBody mass indexTranslational Psychiatry
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Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

2010

Contains fulltext : 89305.pdf (Publisher’s version ) (Closed access) Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 repre…

MaleNetherlands Twin Register (NTR)Lung NeoplasmsSingle-nucleotide polymorphismGenome-wide association studyAetiology screening and detection [ONCOL 5]Receptors NicotinicGenetic analysisArticleMolecular epidemiology [NCEBP 1]Cohort Studies03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingOdds RatioGeneticsmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCYP2A6Lung cancerAlleles030304 developmental biologyGenetics0303 health sciencesbiologyCHRNA6CHRNA5Hormonal regulation [IGMD 6]SmokingGenetic VariationGenomicsTobacco Use DisorderOdds ratiomedicine.disease3. Good healthPhenotypeEvaluation of complex medical interventions [NCEBP 2]genome-wide association nicotinic acetylcholine-receptors lung-cancer susceptibility locus molecular-genetics heavy smoking adult twins dependence genes snpsbiology.protein/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleAryl Hydrocarbon Hydroxylases030217 neurology & neurosurgeryGenome-Wide Association Study
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Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoart…

2019

Berenbaum, Francis/0000-0001-8252-7815; Dennison, Elaine/0000-0002-3048-4961; Bindels, Laure B./0000-0003-3747-3234; Cooper, Cyrus/0000-0003-3510-0709 WOS:000491638300002 PubMed ID: 31437484 The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and t…

0301 basic medicineAgingmedicine.medical_specialtyOsteoporosisPsychological interventionOsteoarthritisGut microbiotaGut floraDysbiosis; Gut microbiota; Inflammaging; Modern diet; Obesity; OsteoarthritisBiochemistry03 medical and health sciences0302 clinical medicineOsteoarthritismedicineAnimalsHumansMusculoskeletal DiseasesObesityModern dietIntensive care medicineMolecular BiologySocieties MedicalInflammationbiologybusiness.industrymedicine.diseasebiology.organism_classificationObesityInflammagingDysbiosiInflammaging ObesityGastrointestinal MicrobiomeEurope030104 developmental biologyNeurologyOsteoporosisDysbiosisObservational studyOsteoarthritiMetabolic syndromebusinessDysbiosis030217 neurology & neurosurgeryBiotechnology
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