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RESEARCH PRODUCT
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
Matti IsohanniAndrew C. HeathThomas MuellerMark I. MccarthyMark I. MccarthyJose I. MayordomoNilesh J. SamaniHogni OskarssonShen Huei-yiShen Huei-yiGonneke WillemsenKatja K.h. AbenLeena PeltonenLeena PeltonenSteinn JonssonMaria KrestyaninovaJouke-jan HottengaKari StefanssonKari StefanssonHreinn StefanssonMarkus PerolaMaria D. Garcia-pratsMichael StumvollNajaf AminInga ProkopenkoNicole VogelzangsIda SurakkaIda SurakkaFrank GellerMassimo ManginoVeikko SalomaaNicholas G. MartinAna M. ValdesJacqueline M. VinkIris H GudjonsdottirPatrick SulemAsger DirksenAlbert HofmanLambertus A. KiemeneyPamela A. F. MaddenThorarinn TyrfingssonNorbert DahmenAnke TönjesChristian GiegerJaana LaitinenAlistair S. HallMeinhard HaltmayerReedik MägiReedik MägiTim D. SpectorMaxine AllenH-erich WichmannMartin Den HeijerJaakko KaprioJaakko KaprioMarjo-riitta JärvelinStefan WalterPeter KovacsClaire J. StevesRajesh RawalBerta SaezUnnur ThorsteinsdottirUnnur ThorsteinsdottirBrenda W.j.h. PenninxVictoria LezcanoYurii S. AulchenkoJohannes KettunenAnna-liisa HartikainenDorret I. BoomsmaDaniel F. GudbjartssonAndre M. Van RijKaisu KeskitaloThorunn RafnarCornelia M. Van DuijnSamuli RipattiSamuli RipattiWilbur A. FranklinAndres MetspaluAndres MetspaluHolly J. WolfJesper Holst PedersenAndré G. UitterlindenHaseem AshrafGregory T. JonesNicole SoranzoNicole SoranzoBarbara NitzThorgeir E. ThorgeirssonBen A. OostraJohn R. ThompsonMari NelisMari NelisJeffrey R. GulcherDan RujescuAngela DöringJes LindholtHenning TiemeierIna GieglingGrant W. MontgomeryAnneli PoutaBenjamin DieplingerSolveig GretarsdottirMichele L. PergadiaStefan E MatthiassonVeronica De DiegoTõnu EskoTõnu Eskosubject
MaleNetherlands Twin Register (NTR)Lung NeoplasmsSingle-nucleotide polymorphismGenome-wide association studyAetiology screening and detection [ONCOL 5]Receptors NicotinicGenetic analysisArticleMolecular epidemiology [NCEBP 1]Cohort Studies03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingOdds RatioGeneticsmedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCYP2A6Lung cancerAlleles030304 developmental biologyGenetics0303 health sciencesbiologyCHRNA6CHRNA5Hormonal regulation [IGMD 6]SmokingGenetic VariationGenomicsTobacco Use DisorderOdds ratiomedicine.disease3. Good healthPhenotypeEvaluation of complex medical interventions [NCEBP 2]genome-wide association nicotinic acetylcholine-receptors lung-cancer susceptibility locus molecular-genetics heavy smoking adult twins dependence genes snpsbiology.protein/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleAryl Hydrocarbon Hydroxylases030217 neurology & neurosurgeryGenome-Wide Association Studydescription
Contains fulltext : 89305.pdf (Publisher’s version ) (Closed access) Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 represented by rs1051730[A] (effect size = 0.80 CPD, P = 2.4 x 10(-69)), and SNPs at 19q13 and 8p11, represented by rs4105144[C] (effect size = 0.39 CPD, P = 2.2 x 10(-12)) and rs6474412-T (effect size = 0.29 CPD, P = 1.4 x 10(-8)), respectively. Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence. Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006). 01 mei 2010
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-31 |