Search results for "DSS"
showing 10 items of 90 documents
Decision support systems (DSS) for wastewater treatment plants - A review of the state of the art.
2019
The use of decision support systems (DSS) allows integrating all the issues related with sustainable development in view of providing a useful support to solve multi-scenario problems. In this work an extensive review on the DSSs applied to wastewater treatment plants (WWTPs) is presented. The main aim of the work is to provide an updated compendium on DSSs in view of supporting researchers and engineers on the selection of the most suitable method to address their management/operation/design problems. Results showed that DSSs were mostly used as a comprehensive tool that is capable of integrating several data and a multi-criteria perspective in order to provide more reliable results. Only …
The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
2019
Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads to an increased frequency of Treg cells, while enforced MAZR expression impairs Treg cell differentiation. Further, MAZR expression levels are progressively downregulated during thymic Treg cell development and during in-vitro-induced human Treg cell differentiation, suggesting that MAZR protein levels are critical for controlling Treg cell development. However, MAZR-deficient Treg cells show only minor transcriptional changes ex vivo, indicating…
Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation assoc…
2017
IF 2.759; International audience; In the present study, we have investigated the effects of polyphenol-rich infusions from carob leaves and OFI-cladodes on inflammation associated with obesity and dextran sulfate sodium (DSS)-induced ulcerative colitis in Swiss mice. In vitro studies revealed that aqueous extracts of carob leaves and OFI-cladodes exhibited anti-inflammatory properties marked by the inhibition of IL-6, TNF-α and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells concomitant with NF-κβ nucleus translocation inhibition. For in vivo investigations, Swiss male mice were subjected to control or high fat diet (HFD). At the 8th week after the start …
H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice
2020
Deregulation of the dynamic crosstalk between the gut microbiota, intestinal epithelial cells, and immune cells is critically involved in the development of inflammatory bowel disease and the overgrowth of opportunistic pathogens, including the human opportunistic fungus Candida albicans. In the present study, we assessed the effect of N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89), a protein kinase A inhibitor, on the migration of macrophages to C. albicans through dextran sulphate sodium (DSS)-challenged Caco-2 cells. We also investigated the impact of H89 on intestinal inflammation and C. albicans clearance from the gut, and determined the diversity of the gut microbio…
Extracellular Vesicles From the Helminth Fasciola hepatica Prevent DSS-Induced Acute Ulcerative Colitis in a T-Lymphocyte Independent Mode
2018
The complexity of the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) has led to the quest of empirically drug therapies, combining immunosuppressant agents, biological therapy and modulators of the microbiota. Helminth parasites have been proposed as an alternative treatment of these diseases based on the hygiene hypothesis, but ethical and medical problems arise. Recent reports have proved the utility of parasite materials, mainly excretory/secretory products as therapeutic agents. The identification of extracellular vesicles on those secreted products opens a new field of investigation, since they exert potent immunomodulating effects. To assess the ef…
Socialt stöd, känsla av ensamhet och psykiska besvär bland finlandssvenska ungdomar
2021
I den här studien utforskades ifall det förekommer sociodemografiska skillnader i upplevelse av psykiska besvär, socialt stöd och känsla av ensamhet bland finlandssvenska ungdomar. Det undersöktes även ifall ungdomarnas upplevelse av psykiska besvär kan förklaras med familje-, kamrat- och klasskamratstöd samt känsla av ensamhet. Utöver det utforskades ifall samband mellan socialt stöd och psykiska besvär kan förklaras med känsla av ensamhet.
 Som datamaterial användes WHO:s skolelevstudie (WHO-Koululaistutkimus) från 2018 med ett deltagarantal på 599 svenskspråkiga elever från årskurs 5, 7 och 9 (Målder = 11,9/14,0/15,9; svarsprocent 38 %). Som statistiska analysmetoder användes Pearso…
Using AHP methodology for prioritizing the actions in the transport sector in the frame of SECAPs
2020
The drafting of the Sustainable Energy and Climate Action Plan, required for the local authorities joining the Covenant of Mayors initiative, is an opportunity to plan actions reducing greenhouse gas emissions in the transport sector. Choosing the measures to implement requires the application of a methodology that compares them, considering costs and impacts in terms of energy consumption, emissions reduction, and social benefits. The paper aims to develop a method based on the typical approach of the Analytical Hierarchy Process, supporting decisions in the transport sector in the frame of the drafting of SECAP. The method allows determining the priority actions and the optimal allocation…
Omat projektit : henkilöhahmojen kapinat Tomas Arvidssonin romaaneissa Utanförskapet ja Trippelstöten
2006
Kognitīvo traucējumu izvērtērtēšana multiplās sklerozes pacientiem ar dažādu klīnisko norisi
2015
Ievads: Tēmu par kognitīvajiem traucējumiem multiplās sklerozes pacientiem es izvēlējos tāpēc, ka tā ir ļoti aktuāla problēma, jo kognitīvie traucējumi var būtiski ietekmēt darbspējas, sociālo aktivitāti un aprūpes nepieciešamību. Darba mērķis: Izvērtēt kognitīvos traucējumus multiplās sklerozes pacientiem ar dažādu klīnisko norisi; Metodes un materiāli: Pētījumā analizēju 120 dažāda vecuma pacientus, no kuriem 60 multiplās sklerozes pacienti ar dažādu klīnisko norisi, kuri ārstējas Latvijas Jūras medicīnas centra Latvijas Multiplās sklerozes centrā un 60 pacienti kontroles grupa, kam nav diagnosticēta multiplā skleroze. Šim nolūkam izmantoju standartizētus testus – SDMT, BVMT-R un CvLT II,…