Search results for "DUP"

Severity of Asymptomatic Carotid Stenosis and Risk of Ipsilateral Hemispheric Ischaemic Events: Results from the ACSRS Study

2005

Objectives. This study determines the risk of ipsilateral ischaemic neurological events in relation to the degree of asymptomatic carotid stenosis and other risk factors. Methods. Patients (n = 1115) with asymptomatic internal carotid artery (ICA) stenosis greater than 50% in relation to the bulb diameter were followed up for a period of 6-84 (mean 37.1) months. Stenosis was graded using duplex, and clinical and biochemical risk factors were recorded. Results. The relationship between ICA stenosis and event rate is linear when stenosis is expressed by the ECST method, but S-shaped if expressed by the NASCET method. In addition to the ECST grade of stenosis (RR 1.6; 95% CI 1.21-2.15), histor…

Tissue-specific mosaicism in a patient with Rubinstein–Taybi syndrome and CREBBP exon 1 duplication

2019

Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae

2012

15 pages, 4 figures, supplementary material

A Learning Automata Local Contribution Sampling Applied to Hydropower Production Optimisation

2017

Learning Automata (LA) is a powerful approach for solving complex, non-linear and stochastic optimisation problems. However, existing solutions struggle with high-dimensional problems due to slow convergence, arguably caused by the global nature of feedback. In this paper we introduce a novel Learning Automata (LA) scheme to attack this challenge. The scheme is based on a parallel form of Local Contribution Sampling (LCS), which means that the LA receive individually directed feedback, designed to speed up convergence. Furthermore, our scheme is highly decentralized, allowing parallel execution on GPU architectures. To demonstrate the power of our scheme, the LA LCS is applied to hydropower…

Phylogenetic relationship of ubiquitin repeats in the polyubiquitin gene from the marine sponge Geodia cydonium

1994

Ubiquitin is a 76-residue protein which is highly conserved among eukaryotes. Sponge (Porifera) ubiquitin, isolated from Geodia cydonium, is encoded by a gene (termed GCUBI) with six repeats, GCUBI-1 to GCUBI-6. All repeat units encode the same protein (with one exception: GCUBI-4 encodes ubiquitin with a change of Leu to Val at position 71). On the nt level the sequences of the six repeats differ considerably. All changes (except in GCUBI-4) are silent substitutions, which do not affect the protein structure. However, there is one major difference between the repeats: Codons from both codon families (TCN and AGPy) are simultaneously used for the serine at position 65. Using this characteri…

Deriving and comparing deduplication techniques using a model-based classification

2015

Data deduplication has been a hot research topic and a large number of systems have been developed. These systems are usually seen as an inherently linked set of characteristics. However, a detailed analysis shows independent concepts that can be used in other systems. In this work, we perform this analysis on the main representatives of deduplication systems. We embed the results in a model, which shows two yet unexplored combinations of characteristics. In addition, the model enables a comprehensive evaluation of the representatives and the two new systems. We perform this evaluation based on real world data sets.

Evolution and functional differentiation of recently diverged phytochelatin synthase genes from Arundo donax L.

2019

Plant phytochelatin synthases undergo evolutionarily rapid functional differentiation after duplication, allowing fast and precise adjustment of metal detoxification capacity by modulation of both transcription and enzymatic activity.

Design and implementation of an embedded coprocessor with native support for 5D, quadruple-based Clifford algebra

2013

Geometric or Clifford algebra (CA) is a powerful mathematical tool that offers a natural and intuitive way to model geometric facts in a number of research fields, such as robotics, machine vision, and computer graphics. Operating in higher dimensional spaces, its practical use is hindered, however, by a significant computational cost, only partially addressed by dedicated software libraries and hardware/software codesigns. For low-dimensional algebras, several dedicated hardware accelerators and coprocessing architectures have been already proposed in the literature. This paper introduces the architecture of CliffordALU5, an embedded coprocessing core conceived for native execution of up t…

A New Embedded Coprocessor for Clifford Algebra based Software Intensive Systems

2011

Computer graphics applications require efficient tools to model geometric objects and their transformations. Clifford algebra (also known as geometric algebra) is receiving a growing attention in many research fields, such as computer graphics, machine vision and robotics, as a new, interesting computational paradigm that offers a natural and intuitive way to perform geometric calculations. At the same time, compute-intensive graphics algorithms require the execution of million Clifford operations. Clifford algebra based software intensive systems need therefore the support of specialized hardware architectures capable of accelerating Clifford operations execution. In this paper the archite…

State of the art in passive digital image forgery detection: copy-move image forgery

2017

Authenticating digital images is increasingly becoming important because digital images carry important information and due to their use in different areas such as courts of law as essential pieces of evidence. Nowadays, authenticating digital images is difficult because manipulating them has become easy as a result of powerful image processing software and human knowledge. The importance and relevance of digital image forensics has attracted various researchers to establish different techniques for detection in image forensics. The core category of image forensics is passive image forgery detection. One of the most important passive forgeries that affect the originality of the image is cop…