Search results for "Dam"

Damage identification by Lévy ant colony optimization

2010

This paper deals with the identification of incipient damage in structural elements by non-destructive test based on experimentally measured structural dynamical response. By applycation of the Hilbert transform to the recorded signal the so-called phase of the analytical signal is recovered and a proper functional is constructed in such a way that its global minimum gives a measure of the damage level, meant as stiffness reduction. Minimization is achieved by applying a modified Ant Colony Optimization (ACO) for continuous variables, inspired by the ants’ forageing behavior. The modification consists in the application of a new perturbation operator, based on alpha stable Lévy distribution…

Hirnprotektion unter Notfallbedingungen: Sind Anästhetika neuroprotektiv?

1997

Glutamate Enhances Brain Damage from Ischemia and Trauma

1997

The amino acid glutamate is a model agent to demonstrate the significance of neurotoxic mediator compounds in secondary brain damage from trauma, ischemia or other adverse conditions. Intensive research of the role of mediator compounds is clinically worthwile as more specific forms of treatment may emerge for the benefit of afflicted patients. In view of the great number of factors, cytokines, etc., which could play a role, it is mandatory that a mediator function in secondary brain damage is identified according to the stringent requirements established for that purpose. Glutamate has been shown — as is the case for only a few other agents — to meet all the criteria of a mediator of secon…

New cerebral protection strategies.

2005

PURPOSE OF REVIEW This article presents an overview of the most recent and important strategies to reduce secondary brain damage. RECENT FINDING There is currently no magic bullet available to protect the brain after neuronal injury. This is related to the complex pathophysiology of cerebral ischemia, which makes it unlikely that a single pharmacological intervention results in sustained neuroprotection. Analyses of clinical studies reveal that acute physiologic derangements (e.g. fever, hypertension and hypotension, hypoxemia, hypercapnia, hyperglycemia) are the most important predictors of unfavorable outcome after brain injury and have to be treated. The effectiveness of anesthetic agent…

Investigation of buckling characteristics of cracked variable stiffness composite plates by an eXtended Ritz approach

2021

Abstract Variable Angle Tow (VAT) composite plates are characterized by in-plane variable stiffness properties, which opens to new concepts of stiffness tailoring and optimization to achieve higher structural performance for advanced lightweight structures where damage tolerance consideration are often mandatory. In this paper, a single-domain eXtended Ritz formulation is proposed to study the buckling behaviour of variable stiffness laminated cracked plates. The plate behaviour is described by the first order shear deformation theory whose generalized displacements, namely reference plane translations and rotations, are expressed via suitable admissible trial functions. These consist of a …

Immune pathogenesis of hepatitis A

1992

In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.

Shakedown of Structures Accounting for Damage Effects

2002

Shakedown theory for elastic-plastic-damage materials is exposed. Two kinds of shakedown are considered: i) Enlarged shakedown (or simply shakedown), in which both plastic deformations and damage eventually cease, after which the structural response is purely elastic; ii) Weak-form shakedown, in which plastic deformations eventually cease together with their consequences (including ductile damage), not necessarily damage from other sources (which are however escluded by assumption). An (enlarged) shakedown static-type theorem is given for a class of D-stable structures. Sufficient theorems of weak-form shakedown are provided, i.e. a static-type one (quite similar to that of Hachemi and Weic…

INNOVATIVE MASS-DAMPING-BASED APPROACHES FOR SEISMIC DESIGN OF TALL BUILDINGS

2021

Mass damping is a well known principle for the reduction of structural vibrations and applied in tall building design in a variety of configurations. With mass usually small (around 1% of building mass), the properly “tuned” mass damper (TMD) shows great effectiveness in reduc-ing wind vibrations, but minor advantages under earthquake excitations. The above limitation can be surpassed by utilizing relatively large mass TMD. For this pur-pose, two different solutions are here proposed. In both cases, the idea is to separate the building into two or more parts, thus allowing for a relative motion between them, and acti-vating the mass damping mechanism. In the first solution, the building is …

Endogenous Agents That Contribute to Generate or Prevent Ischemic Damage

2012

From single to multicellular organisms, protective mechanisms have evolved against endogenous and exogenous noxious stimuli. Over the past decades numerous signaling pathways by which the brain senses and reacts to such insults as neurotoxins, substrate deprivation and inflammation have been discovered. Research on preconditioning is aimed at understanding endogenous neuroprotection to boost it or to supplement its effectors therapeutically once damage to the brain has occurred, such as after stroke or brain trauma. Another goal of establishing preconditioning protocols is to induce endogenous neuroprotection in anticipation of incipient brain damage. Currently several endogenous neuroprote…

Konfokale Laser-Scanning-Mikroskopie (CLSM): Histotomographie veränderter Zahnhartgewebe bei pathologischer Mundhöhlenökologie

1997

There is no consensus regarding the aetiology of radiation-induced caries. Lesion formation is assumed to originate either from direct radiogenic damage of the hard tissue or from the indirect effects correlated with radioxerostomia. A comparative study is presented of sound teeth (group 1), teeth with documented radiation caries (group 2), teeth after in situ radiation (group 3): 60 Gy, fractionated) and teeth after in vitro radiation (group 4: 500-2500 Gy). Radiations were carried out with a 60Co source. The dentoenamel junction was studied with confocal laser scanning microscopy (CLSM). Axial sections of the teeth were used either fresh or embedded in Technovit (sawing-grinding technique…