Search results for "Dam"
showing 10 items of 3828 documents
Dampness and student-reported social climate: two multilevel mediation models.
2021
Background Little previous research has analysed the relationship between schools' indoor air problems and schools' social climate. In this study, we analysed a) whether observed mould and dampness in a school building relates to students' perceptions of school climate (i.e. teacher-student relationships and class spirit) and b) whether reported subjective indoor air quality (IAQ) at the school level mediates this relationship. Methods The data analysed was created by merging two nationwide data sets: survey data from students, including information on subjective IAQ (N = 25,101 students), and data from schools, including information on mould and dampness in school buildings (N = 222). The …
"The past lay claim to the present" memory and narrative as a journey to one's self : a study of Damon Galgut's In a Strange Room
2013
Eteläafrikkalainen kirjallisuus on pitkään keskittynyt maan vaikean historian avaamiseen niin yhteiskunnallisella kuin yksilönkin tasolla. Tärkeitä teemoja ovat olleet niin identiteetin luominen siirtymävaiheessa olevassa yhteiskunnassa kuin myös yhteyden luominen menneisyyden ja nykyisyyden välille. Kirjallisuudessa on myös pitkä omaelämänkerrallisuuden historia, jonka alku on kirjallisuuden vapautumisessa poliittisista kytköksistä ja yksityisen kokemuksen kuvaamisen lisääntymisessä. Damon Galgutin In a Strange Room (2010) yhtäältä jatkaa näitä traditioita, mutta toisaalta myös kehittää niitä edelleen. Romaani on oletettavasti Galgutin osittainen omaelämankerta, jonka keskiössä on itsen ra…
Effect of the serum from multiple sclerosis patients on an in vitro model of blood-brain barrier.
2008
Multiple sclerosis (MS) is characterized by focal inflammatory demyelination, largely due to autoimmune responses against different components of the myelin sheet. It is also generally accepted that the pathogenesis of MS consists of inflammatory and neurodegenerative phases, where demyelination should produce partially reversible clinical deficits that can remit, due to limited remyelination, while axonal degeneration produces permanent non-remitting clinical damage. It is also assumed that nervous system inflammation is initiated by autoreactive, myelin-specific T cells that permeate the blood-brain barrier and trigger a series of events leading to tissue destruction. In addition to antib…
Predicting mechanical behaviour and damage kinetics of a 3D interlock composite materials by using a multiscale approach
2012
International audience; The present work aims to investigate the mechanical behaviour and the damage kinetics of a3D interlock woven fabric composite, especially used for natural gas tanks dedicated to thetransportation industry. On the one hand, we aim at predicting the macroscopic coefficients ofthe stiffness matrix by homogenization multiscale approach. For this, we identified a basicunit cell which represents well the composite microstructure. On the other hand, damagemechanisms are analyzed: optical microscopy examinations on damaged specimens revealedseveral types of defects. We used the same multi-scale approach to assess the impact of thesedefects on the decrease of stiffness.
Ultrasound evaluation of joint damage and disease activity in adult patients with severe haemophilia A using the HEAD‐US system
2021
Introduction The Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) system and scoring scale has proven to be an accurate and time-efficient imaging method for identifying joint damage in patients with haemophilia. Aim Observational, multicentre, cross-sectional study conducted in 8 centres in Spain that assessed the joint status of adult patients with severe haemophilia A (SHA) using HEAD-US. Methods Joint status of the elbow, knee and ankle was evaluated in adults with SHA receiving on-demand (OD) treatment, or primary (PP), secondary (SP), tertiary (TP) or intermittent (IP) prophylaxis. Results Of the 95 patients enrolled, 87 received prophylaxis (6.3% PP, 38.9% SP, 43.2% …
Mouse CSB protein is important for gene expression in the presence of a single-strand break in the non-transcribed DNA strand.
2010
CSB protein is required for strand-specific repair of bulky DNA lesions in transcribed genes and mediates transcription recovery after exposure to DNA-damaging agents. We enzymatically generated DNA single-strand breaks (SSBs) with 3'-OH and 5'-phosphate termini in defined positions of a plasmid-borne gene and measured their effect on transcription in cell lines with different statuses of the Csb gene. A single SSB in the transcribed region of the gene caused significant decrease of gene expression. In all tested cell lines of mouse and human origin, a SSB in the transcribed DNA strand was less harmful for gene expression than a SSB situated in the opposing DNA strand. CSB deficiency exhibi…
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA b…
2002
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Evaluation of radiological findings with COVID-19 lung lesions in Latvia in the view of artificial intelligence and radiologist
2022
Pēc Pasaules Veselības organizācijas datiem kopš pandēmijas sākuma kopējais ar Covid-19 saslimušo cilvēku skaits pārsniedz 500 miljonus. Mākslīgais intelekts (MI) paver plašas iespējas Covid-19 infekcijas izraisīto plaušu bojājumu diagnostikā, kas var uzlabot un atvieglojot radiologa darbu veicinot gan izmeklējuma specifitātes, gan sensitivitātes izvērtēšanas iespējas. Šī pētījuma galvenais mērķis bija salīdzināt MI un radiologa atradnes precizitāti Covid-19 radītā plaušu bojājuma izvērtēšanā un noteikt interpretācijas ierobežojumus un priekšrocības klīniskā kontekstā. Savukārt darba uzdevumi bija iepazīties un apkopot datus ar jaunāko literatūru par MI pielietošanas iespējām medicīnā. Apko…
Polymeric Nanogels: Nanocarriers For Drug Delivery Application.
2012
The application of nanotechnology to medicine has enabled the development of functionalised nanoparticles that, acting as carriers, can be loaded with drugs or genetic material to be released with a controlled mechanism in specific districts of the organism. Even though nanomedicine is a relative new branch of science, many type of nanocarriers for drug delivery have been developed over the past 30 years, such as liposomes, dendrimers, quantum dots, solid lipid nanoparticles, viruses and virus-like nanoparticles as well as a wide var iety of polymeric nanoparticles. Among these last, in our opinion, nanogels deserve a special attention. Nanogels are nanoscalar polymer networks, with a tende…