Search results for "Dama"

Role of Nitric Oxide for Modulation of Cancer Therapy Resistance

2010

Reactive nitrogen species (RNS) act as central second messengers in a balanced cellular network. While the complexity of nitric oxide (NO) signaling is far from being understood, and many controversial data can be found in the literature, there is evidence for NO as a major player of modulation of resistance to anticancer drugs and radiotherapy. Hypoxia in cancer tissues causes therapy resistance, and the hypoxia-inducing factor-1 (HIF-1) plays a predominant role in hypoxia-induced resistance. NO and NO-donating compounds sensitize tumor cells by inhibiting HIF-1 mediated transcription in hypoxic cells. Among a plethora of other genes, HIF-1-induced the transcription of the multidrug resist…

Characterization of hOGG1 Promoter Structure, Expression During Cell Cycle and Overexpression in Mammalian Cells

2001

Oxygen radicals are produced in all cells either by the normal cellular metabolism or by the exposure to external mutagens. The reactive oxygen species (ROS) generated can induce DNA damage. Among the principal lesions found in DNA due to ROS is an oxidized form of guanine, 8-oxo-7,8-dihydroguanine (8-oxoG). The biological relevance of this lesion has been unveiled by the study of Escherichia colt and Saccharomyces cerevisiae genes involved in the neutralization of the mutagenic effects of 8-oxoG (Cabrera et al., 1988; Nghiem et al., 1988; Radicella et al., 1988; van der Kemp et al., 1996). These genes fpg and mutY for E. colt and OGG1 for yeast, code for DNA glycosylases. Inactivation of a…

Targeting the Mitochondria by Novel Adamantane-Containing 1,4-Dihydropyridine Compounds

2012

Linda Klimaviciusa1, Maria A. S. Fernandes2, Nelda Lencberga1, Marta Pavasare1, Joaquim A. F. Vicente2, Antonio J. M. Moreno2, Maria S. Santos3, Catarina R. Oliveira4, Imanta Bruvere5, Egils Bisenieks5, Brigita Vigante5 and Vija Klusa1 1Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga 2IMAR-CMA, Department of Life Sciences, University of Coimbra, Coimbra 3CNC, Department of Life Sciences, University of Coimbra, Coimbra 4CNC, Faculty of Medicine, University of Coimbra, Coimbra 5Laboratory of Membrane Active and beta-Diketone Compounds, Latvian Institute of Organic Synthesis, Riga 2,3,4Portugal 1,5Latvia

[39] DNA damage induced by ultraviolet and visible light and its wavelength dependence

2000

Publisher Summary DNA damage induced by solar radiation in mammalian cells consists largely of two types of modification: pyrimidine dimers and oxidative modifications. Pyrimidine dimmers that can be subdivided into cyclobutane pyrimidine dimmers, (CPDs) and (6-4) photoproducts are the characteristic and most abundant modifications after direct excitation of DNA, although they can also be formed indirectly by energy transfer from other excited molecules such as carbonyl compounds. Oxidative DNA damage, which includes various pyrimidine and purine modifications, sites of base loss (AP sites), and strand breaks, is generated in only low yield after direct excitation of DNA (except at very sho…

The First Clamped and Strongly Deformed Adamantane

1990

Environmental noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1−/− mice

2020

LA CLASS ACTION E LA FUNZIONE DI DETERRENZA DEGLI ILLECITI CIVILI IN PROSPETTIVA COMPARATISTICA

2010

La ricerca affronta l'esame dell'istituto della class action o azione collettiva risarcitoria da tempo esistente nel sistema americano e di recente recepito nell'ordinamento italiano, attraverso la L.23 luglio 2009 n.99, che ha modificato la pregressa disciplina di cui all'art.2 comma 446 della L. 24 dicembre 2007 n.244 (finanziaria 2008), sia pur con alcune rilevanti differenze rispetto al sistema americano che ne riducono le potenzialità applicative (si consideri, ad es., la scelta italiana del sistema di opt-in piuttosto che del sistema di opt-out). Accanto alla class action - per l'analoga funzione di deterrenza - si esaminano i c.d. punitive damages o danni punitivi, per lungo tempo di…

Pour une approche cognitive et multiscalaire des conflits environnementaux

2011

Starting with artificial light as new object damage and emerging environmental problem, this paper intends to develop a general reflection showing the importance of a greater consideration of cognitive dimensions of the damage and risk analysis in environmental conflicting processes. We show how the cost-benefit analysis after the neoclassical theory of production, often used in the search for Pareto-optimal state and in the policies of monetary compensation to resolve environmental conflicts can - indeed must - be strongly challenged. Also, with this reasoning, we oppose an analysis in terms of cognitive interactions that groups develop around environmental goods and items of damage, thus …

Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Ag…

2019

Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Yet, perinatal brain damage has limited therapeutic outcomes. Besides, the immature brain of premature children is at increased risk of hypoxic/ischemic (HI) injury, with males being more susceptible to it and less responsive to protective/therapeutical interventions. Here, we model in male and female C57BL/6 mice, the impact of neonatal HI and the protective effects of neonatal handling (NH), an early life tactile and proprioceptive sensory stimulation. From postnatal day 1 (PND1, modeling pre-term) to PND21 randomized litters received either…

Bisfenola A saturošo zobārstniecības kompozītu genotoksicitāte

2019

Daži zobārstniecībā izmantojamie sveķu kompozīti satur monomērus ar BPA kā bāzes elementu, kas izraisa dzīvo šūnu genotoksicitāti un spēj izraisīt dzīvo šūnu nāvi. Šie monomēri spēj noārdīties cilvēka siekalās esošo esterāžu iedarbībā, tādējādi izdalot toksiskos noārdīšanās produktus mutes dobumā. Izdalītie monomēri pat var iekļūt asinsritē, izejot cauri zoba struktūrām uz pulpu. Šī pētījuma mērķis bija izpētīt zobārstniecības kompozīta materiālu ietekmi uz cilvēka asins šūnām, tieši uz limfocītiem, un novērtēt šūnu DNS bojājumu līmeni. Lai izpētītu šo jautājumu, 4 dažādi komerciāli pieejamie zobārstniecības kompozīta materiālu fragmenti tika izmērcēti izolētās cilvēka perifēro asiņu mononu…