Search results for "Danes"

A Twin Protection Effect? Explaining Twin Survival Advantages with a Two-Process Mortality Model

2016

Twin studies that focus on the correlation in age-at-death between twin pairs have yielded important insights into the heritability and role of genetic factors in determining lifespan, but less attention is paid to the biological and social role of zygosity itself in determining survival across the entire life course. Using data from the Danish Twin Registry and the Human Mortality Database, we show that monozygotic twins have greater cumulative survival proportions at nearly every age compared to dizygotic twins and the Danish general population. We examine this survival advantage by fitting these data with a two-process mortality model that partitions survivorship patterns into extrinsic …

Longitudinal Investigation into Genetics in the Conservation of Metabolic Phenotypes in Danish and Chinese Twins

2016

Longitudinal twin studies on long term conservation of individual metabolic phenotypes can help to explore the genetic and environmental basis in maintaining metabolic homeostasis and metabolic health. We performed a longitudinal twin study on 12 metabolic phenotypes from Danish twins followed up for 12 years and Chinese twins traced for 7 years. The study covered a relatively large sample of 502 pairs of Danish adult twins with a mean age at intake of 38 years and a total of 181 Chinese adult twin pairs with a mean baseline age of 39.5 years. Bivariate twin models were fitted to the longitudinal measurements taken at two time points (at baseline and follow-up) to estimate the genetic and e…

Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of opioid receptor affinity

2008

Abstract Salvinorin A ( 1 ), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum , is the only known non-nitrogenous and specific κ-opioid agonist. Several structural congeners of 1 isolated from Salvia splendens ( 2 – 8 ) together with a series of semisynthetic derivatives ( 9 – 24 ), some of which possess a pyrazoline structural moiety ( 9 , 19 – 22 ), have been tested for affinity at human μ, δ, and κ opioid receptors. None of these compounds showed high affinity binding to these receptors. However, 10 showed modest affinity for κ receptors suggesting that other natural neoclerodanes from different Salvia species may possess opioid affinity.

Normanowie, wikingowie a ich przedstawienia w świecie gier komputerowych (na wybranych przykładach)

2018

Pomimo ogromnego postępu w badaniach skandynawskich i normańskich, istnieje jeszcze pole we współczesnej popkulturze, które powiela pewne stare stereotypy. To rynek gier komputero-wych, który kwitnie od ponad czterdziestu lat. Dlatego w artykule przedstawiono to zjawisko chronologicznie – na wybranych przykładach od lat 80. do chwili obecnej. Uczyniono to na pod-stawie tytułów na komputery C, najczęściej strategii i gier R G (Role laying Games), ponieważ ta platforma jest jedną z najstarszych i pomimo szybkiego rozwoju konsol, wciąż im nie uległa. Niestety, nie istnieje literatury naukowa poświęcona wikingom i Normanom w grach wideo, więc do pewnego stopnia badania są pionierskie. Podczas g…

Hastifolins A-G, antefeedant neo-clerodane diterpenoids from Scutellaria hastifolia

2010

From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A-G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A-C showed significant antifeedant activity.

Altri apporti della terza famiglia ai Getica di Giordanes

2004

Ancora sugli apporti della terza famiglia ai Getica di Giordanes

2005

Nel presente saggio, come in altri che l’hanno preceduto, si approfondisce l’apporto non indifferente della terza famiglia (dei contributi della seconda si dice in altri lavori) alla costituzione del testo dei Getica di Iordanes, che Mommsen (1882;rist.1961), senza la dovuta attenzione, sottovalutò a favore della prima famiglia, in cui sono tutt’altro che infrequenti le mende di un copista, che svolse malamente le abbreviazioni frequenti di fronte alle quali si era trovato.

Lessico ed espressioni della gromatica militare dello ps. Igino

2005

La presente relazione, secondo gli indirizzi del congresso francese di Besançon, nei cui Atti è stata pubblicata, riprende in modo conclusivo gli studi, editi al riguardo in anni precedenti, su termini gromatici e geometrici, ma anche su usi linguistici specifici dello ps. Igino nel suo trattatello sulla centuriazione del terreno di un accampamento.

Handgrip strength and its prognostic value for mortality in Moscow, Denmark, and England.

2017

BACKGROUND: This study compares handgrip strength and its association with mortality across studies conducted in Moscow, Denmark, and England.MATERIALS: The data collected by the Study of Stress, Aging, and Health in Russia, the Study of Middle-Aged Danish Twins and the Longitudinal Study of Aging Danish Twins, and the English Longitudinal Study of Ageing was utilized.RESULTS: Among the male participants, the age-standardized grip strength was 2 kg and 1 kg lower in Russia than in Denmark and in England, respectively. The age-standardized grip strength among the female participants was 1.9 kg and 1.6 kg lower in Russia than in Denmark and in England, respectively. In Moscow, a one-kilogram …

The cytosolic Arabidopsis thaliana cysteine desulfurase ABA3 delivers sulfur to the sulfurtransferase STR18

2020

ABSTRACTThe biosynthesis of many sulfur-containing molecules depends on cysteine as a sulfur source. Cysteine desulfurase (CD) and rhodanese (Rhd) domain-containing protein families participate in the trafficking of sulfur for various metabolic pathways in bacteria and human, but their connection is not yet described in plants. The existence of natural chimeric proteins, however, containing both CD and Rhd domains in specific bacterial genera suggests a general interaction between both proteins. We report here the biochemical relationships between two cytosolic proteins from Arabidopsis thaliana, a Rhd domain containing protein, the sulfurtransferase 18 (STR18), and a CD isoform referred to…