Search results for "Data type"
showing 10 items of 1183 documents
Examination of the least-squares method applied to the evaluation of physicochemical parameters with linearized equations
1989
Physicochemical parameters are frequently evaluated by the least-squares method after linearization of the equation which relates the experimental variables to the parameters of interest. When a given set of data is treated to evaluate (n+1) parameters. (n+2) nominally identical linearized equations are possible; each of these leads to different sets of values of the parameters which are also affected by different variances. These differences are also observed when statistical weights are used. Two methods for establishing which one of the (n+2) equations is best for fitting the data, i.e., simulation of experiments and propagation of errors, are discussed, compared and applied to a potenti…
Identification of new claudin family members by a novel PSI-BLAST based approach with enhanced specificity.
2006
In an attempt to develop a novel strategy for the identification of new members of protein families by in silico approaches, we have developed a semi-automated procedure of consecutive PSI-BLAST (Position-Specific-Iterated Basic Local Alignment Search Tool) searches incorporating identificiation as well as subsequent validation of putative candidates. For a proof of concept study we chose the search for novel members of the claudin family. The initial step was an iterated PSI-BLAST search starting with the PMP22_Claudin domain of each known member of the claudin family against the human part of the RefSeq Database. Putative new claudin domains derived from the converged list were evaluated …
Experimental Evaluation of Protein Secondary Structure Predictors
2009
Understanding protein biological function is a key issue in modern biology, which is largely determined by its 3D shape. Protein 3D shape, in its turn, is functionally implied by its amino acid sequence. Since the direct inspection of such 3D structures is rather expensive and time consuming, a number of software techniques have been developed in the last few years that predict a spatial model, either of the secondary or of the tertiary form, for a given target protein starting from its amino acid sequence. This paper offers a comparison of several available automatic secondary structure prediction tools. The comparison is of the experimental kind, where two relevant sets of proteins, a non…
Comparison of classification methods that combine clinical data and high-dimensional mass spectrometry data
2013
Background The identification of new diagnostic or prognostic biomarkers is one of the main aims of clinical cancer research. Technologies like mass spectrometry are commonly being used in proteomic research. Mass spectrometry signals show the proteomic profiles of the individuals under study at a given time. These profiles correspond to the recording of a large number of proteins, much larger than the number of individuals. These variables come in addition to or to complete classical clinical variables. The objective of this study is to evaluate and compare the predictive ability of new and existing models combining mass spectrometry data and classical clinical variables. This study was co…
A no-go result for the quantum damped harmonic oscillator
2019
Abstract In this letter we show that it is not possible to set up a canonical quantization for the damped harmonic oscillator using the Bateman Lagrangian. In particular, we prove that no square integrable vacuum exists for the natural ladder operators of the system, and that the only vacua can be found as distributions. This implies that the procedure proposed by some authors is only formally correct, and requires a much deeper analysis to be made rigorous.
A Constructive Arboricity Approximation Scheme
2020
The arboricity \(\varGamma \) of a graph is the minimum number of forests its edge set can be partitioned into. Previous approximation schemes were nonconstructive, i.e., they approximate the arboricity as a value without computing a corresponding forest partition. This is because they operate on pseudoforest partitions or the dual problem of finding dense subgraphs.
Assessment Tests in the Mathematics Teaching Guides in Spain. Analysis of the Content Blocks and the Treatment of Arithmetic Word Problems
2021
The teaching guides that complement textbooks have key importance in the assessment of competence in problem solving, because these materials contain the assessment tools that teachers frequently use to quantify the achievements of their students. In this paper, we set two aims: to analyze which curriculum contents are given priority in the assessment tests of the teaching guides
Parameter dependence for the positive solutions of nonlinear, nonhomogeneous Robin problems
2020
We consider a parametric nonlinear Robin problem driven by a nonlinear nonhomogeneous differential operator plus an indefinite potential. The reaction term is $$(p-1)$$-superlinear but need not satisfy the usual Ambrosetti–Rabinowitz condition. We look for positive solutions and prove a bifurcation-type result for the set of positive solutions as the parameter $$\lambda >0$$ varies. Also we prove the existence of a minimal positive solution $$u_\lambda ^*$$ and determine the monotonicity and continuity properties of the map $$\lambda \rightarrow u_\lambda ^*$$.
Some coincidence and periodic points results in a metric space endowed with a graph and applications
2015
The purpose of this paper is to obtain some coincidence and periodic points results for generalized $F$-type contractions in a metric space endowed with a graph. Some examples are given to illustrate the new theory. Then, we apply our results to establishing the existence of solution for a certain type of nonlinear integral equation.
Measures with predetermined regularity and inhomogeneous self-similar sets
2016
We show that if $X$ is a uniformly perfect complete metric space satisfying the finite doubling property, then there exists a fully supported measure with lower regularity dimension as close to the lower dimension of $X$ as we wish. Furthermore, we show that, under the condensation open set condition, the lower dimension of an inhomogeneous self-similar set $E_C$ coincides with the lower dimension of the condensation set $C$, while the Assouad dimension of $E_C$ is the maximum of the Assouad dimensions of the corresponding self-similar set $E$ and the condensation set $C$. If the Assouad dimension of $C$ is strictly smaller than the Assouad dimension of $E$, then the upper regularity dimens…