Search results for "Data"
showing 10 items of 12992 documents
Mitigating DDoS using weight‐based geographical clustering
2020
Distributed denial of service (DDoS) attacks have for the last two decades been among the greatest threats facing the internet infrastructure. Mitigating DDoS attacks is a particularly challenging task as an attacker tries to conceal a huge amount of traffic inside a legitimate traffic flow. This article proposes to use data mining approaches to find unique hidden data structures which are able to characterize the normal traffic flow. This will serve as a mean for filtering illegitimate traffic under DDoS attacks. In this endeavor, we devise three algorithms built on previously uncharted areas within mitigation techniques where clustering techniques are used to create geographical clusters …
Changes in Body Composition in Anorexia Nervosa : Predictors of Recovery and Treatment Outcome
2015
The restoration of body composition (BC) parameters is considered to be one of the most important goals in the treatment of patients with anorexia nervosa (AN). However, little is known about differences between AN diagnostic subtypes [restricting (AN-R) and binge/purging (AN-BP)] and weekly changes in BC during refeeding treatment. Therefore, the main objectives of our study were twofold: 1) to assess the changes in BC throughout nutritional treatment in an AN sample and 2) to analyze predictors of BC changes during treatment, as well as predictors of treatment outcome. The whole sample comprised 261 participants [118 adult females with AN (70 AN-R vs. 48 AN-BP), and 143 healthy controls].…
The IceCube prototype string in Amanda
2006
The Antarctic Muon And Neutrino Detector Array (Amanda) is a high-energy neutrino telescope. It is a lattice of optical modules (OM) installed in the clear ice below the South Pole Station. Each OM contains a photomultiplier tube (PMT) that detects photons of Cherenkov light generated in the ice by muons and electrons. IceCube is a cubic-kilometer-sized expansion of Amanda currently being built at the South Pole. In IceCube the PMT signals are digitized already in the optical modules and transmitted to the surface. A prototype string of 41 OMs equipped with this new all-digital technology was deployed in the Amanda array in the year 2000. In this paper we describe the technology and demonst…
Exploiting historical rainfall and landslide data in a spatial database for the derivation of critical rainfall thresholds
2017
Critical rainfall thresholds for landslides are powerful tools for preventing landslide hazard. The thresholds are commonly estimated empirically starting from rainfall events that triggered landslides in the past. The creation of the appropriate rainfall–landslide database is one of the main efforts in this approach. In fact, an accurate agreement between the landslide and rainfall information, in terms of location and timing, is essential in order to correctly estimate the rainfall–landslide relationships. A further issue is taking into account the average moisture conditions prior the triggering event, which reasonably may be crucial in determining the sufficient amount of precipitation.…
Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental asses…
2004
Abstract Helminth infections are a medical problem in the world nowadays. In this paper a novel atom-level chemical descriptor has been applied to estimate the anthelmintic activity. Total and local linear indices and linear discriminant analysis were used to obtain a quantitative model that discriminates between anthelmintic and non-anthelmintic drug-like compounds. The discriminant model has an accuracy of 90.11% in the training set, with a high Matthews’ correlation coefficient (MCC = 0.80). To assess the robustness and predictive power of the obtained model, internal (leave-n-out) and external validation process was performed. The QSAR model correctly classified 88.55% of compounds in t…
Association of derived neutrophil-to-lymphocyte ratio (dNLR) with pathological complete response (pCR) after neoadjuvant chemotherapy (CT)
2019
Abstract Background dNLR is a novel biomarker associated with clinical outcome in solid tumors including early stage breast cancer (BC). Here we report the association of dNLR with pCR in triple-negative (TN) and luminal BC patients (pts) treated with neoadjuvant CT. Methods This was a retrospective analysis of two randomized studies (GEICAM/2006-03 - NCT00432172 and ETNA - NCT01822314) involving 821 pts with early stage (>2cm) or locally advanced TN or luminal BC receiving anthracycline/taxane-based CT +/- carboplatin (GEICAM/2006-03) or nab-paclitaxel/paclitaxel followed by anthracycline regimen (ETNA). dNLR was calculated as the ratio of neutrophils and the difference between total leuko…
On the Classification of Dynamical Data Streams Using Novel “Anti–Bayesian” Techniques
2018
The classification of dynamical data streams is among the most complex problems encountered in classification. This is, firstly, because the distribution of the data streams is non-stationary, and it changes without any prior “warning”. Secondly, the manner in which it changes is also unknown. Thirdly, and more interestingly, the model operates with the assumption that the correct classes of previously-classified patterns become available at a juncture after their appearance. This paper pioneers the use of unreported novel schemes that can classify such dynamical data streams by invoking the recently-introduced “Anti- Bayesian” (AB) techniques. Contrary to the Bayesian paradigm, that compar…
Antiretroviral genotypic resistance in plasma RNA and whole blood DNA in HIV-1 infected patients failing HAART
2008
The extent to which HIV-1 proviral DNA mutations cause clinically relevant antiretroviral resistance is still controversial. Paired plasma HIV-1 RNA and whole blood DNA were compared in patients failing HAART to investigate if the additional knowledge of archived mutations could improve the selection of potentially active drugs. Seventy-three HIV-1-infected patients with first/second HAART failure were studied before starting a new regimen based on RNA genotyping. Follow-up data after a 12-week therapy were available. DNA genotyping was retrospectively performed on stored whole blood samples and mutational profiles were compared to those from RNA. The mean number of IAS pol mutations was si…
Antibody Induction Directed against the Tumor-Associated MUC4 Glycoprotein
2015
Mucin glycoproteins are important diagnostic and therapeutic targets for cancer treatment. Although several strategies have been developed to explore anti-tumor vaccines based on MUC1 glycopeptides, only few studies have focused on vaccines directed against the tumor-associated MUC4 glycoprotein. MUC4 is an important tumor marker overexpressed in lung cancer and uniquely expressed in pancreatic ductual adenocarcinoma. The aberrant glycosylation of MUC4 in tumor cells results in an exposure of its peptide backbone and the formation of tumor-associated glycopeptide antigens. Due to the low immunogenicity of these endogenous structures, their conjugation with immune stimulating peptide or prot…
Flow cytometric immunophenotyping: principles and pitfalls
1992
Within the last decade flow cytometry (FCM) has become an integral part of basic immunological research. Elaboration of this technology has been intensively stimulated by a rapidly growing sophistication in monoclonal antibody technology and vice versa. At present numerous applications are established that allow an increasingly detailed insight into the immune system, however, automation still must be considered the "cinderella of the arts". Thus, transition of this powerful approach from a basic to a routine clinical procedure is much more difficult than expected. Sufficient usage of flow cytometers still requires some knowledge of physics and its technical applications. Moreover, several …