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RESEARCH PRODUCT

Changes in Body Composition in Anorexia Nervosa : Predictors of Recovery and Treatment Outcome

Cristina BotellaMónica Montserrat-gil De BernabeJosé M. MenchónSalomé TárregaAna B CrujeirasAna B. CrujeirasNadine RiescoJon ArcelusJavier Gómez-ambrosiJavier Gómez-ambrosiJana González-gómezSusana Jiménez-murciaSusana Jiménez-murciaGema FrühbeckGema FrühbeckRafael De La TorreJosé Carlos Fernández-garcíaXandra RomeroNuria CustalRosa M. BañosRosa M. BañosIsabel SánchezRoser GraneroRoser GraneroFernando Fernández-arandaFernando Fernández-arandaFrancisco J. TinahonesFelipe F. CasanuevaFelipe F. CasanuevaJosé Manuel Fernández-realJosé Manuel Fernández-realZaida Agüera

subject

Anorexia Nervosa:Psychiatry and Psychology::Mental Disorders::Eating Disorders::Binge-Eating Disorder [Medical Subject Headings]Body water:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]lcsh:MedicineÍndice de masa corporalAnorexia nervosaMetabolismo basal:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]FatsImpedancia eléctricaadolescentslcsh:Science:Psychiatry and Psychology::Mental Disorders::Eating Disorders::Anorexia Nervosa [Medical Subject Headings]eating-disordersBody mass indexMetasMultidisciplinaryBulimia nervosaFemeninoAnorèxia nerviosaTrastorno por atracónModelos logísticos:Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings]HumanosTreatment OutcomeBasal metabolic rate measurementfat distributionbioelectrical-impedanceBody CompositionEating disordersObesitatFemalewomenmedicine.symptomBioelectrical impedance analysisResearch ArticleAdultTejido adiposomedicine.medical_specialtyPatient Dropoutsweight-gainwaterPes corporal:Anatomy::Fluids and Secretions::Body Fluids::Body Water [Medical Subject Headings]Anorexia nerviosa:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goals [Medical Subject Headings]Internal medicine:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Treatment Outcome [Medical Subject Headings]medicineTreatment guidelinesHumansObesityComposición corporal:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Trastorns de la conducta alimentàriabusiness.industrylcsh:Renergy-expenditureduration:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques Endocrine::Thyroid Function Tests::Basal Metabolism [Medical Subject Headings]:Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Body Composition [Medical Subject Headings]Anorexia nervosaBody weightmedicine.diseaseObesityAgua corporalEndocrinology:Check Tags::Female [Medical Subject Headings]Bulimia nervosaCase-Control StudiesBasal metabolic ratelcsh:QResultado del tratamiento:Phenomena and Processes::Physical Phenomena::Magnetic Phenomena::Electromagnetic Phenomena::Electricity::Electric Conductivity::Electric Impedance [Medical Subject Headings]businessBody mass indexWeight gain

description

The restoration of body composition (BC) parameters is considered to be one of the most important goals in the treatment of patients with anorexia nervosa (AN). However, little is known about differences between AN diagnostic subtypes [restricting (AN-R) and binge/purging (AN-BP)] and weekly changes in BC during refeeding treatment. Therefore, the main objectives of our study were twofold: 1) to assess the changes in BC throughout nutritional treatment in an AN sample and 2) to analyze predictors of BC changes during treatment, as well as predictors of treatment outcome. The whole sample comprised 261 participants [118 adult females with AN (70 AN-R vs. 48 AN-BP), and 143 healthy controls]. BC was measured weekly during 15 weeks of day-hospital treatment using bioelectrical impedance analysis (BIA). Assessment measures also included the Eating Disorders Inventory-2, as well as a number of other clinical indices. Overall, the results showed that AN-R and AN-BP patients statistically differed in all BC measures at admission. However, no significant time×group interaction was found for almost all BC parameters. Significant time×group interactions were only found for basal metabolic rate (p = .041) and body mass index (BMI) (p = .035). Multiple regression models showed that the best predictors of pre-post changes in BC parameters (namely fat-free mass, muscular mass, total body water and BMI) were the baseline values of BC parameters. Stepwise predictive logistic regressions showed that only BMI and age were significantly associated with outcome, but not with the percentage of body fat. In conclusion, these data suggest that although AN patients tended to restore all BC parameters during nutritional treatment, only AN-BP patients obtained the same fat mass values as healthy controls. Put succinctly, the best predictors of changes in BC were baseline BC values, which did not, however, seem to influence treatment outcome. Instituto de Salud Carlos III [ISCIII] FIS PI11/00210 FIS PI14/00290 Fondos Europeos de Desarrollo Regional (FEDER) funds Servicio Andaluz de Salud (SAS) B-0033-2014 Instituto de Salud Carlos III [Ministerio de de Economia y Competitividad] PSI2011-28349

yearjournalcountryeditionlanguage
2015-11-23
https://ddd.uab.cat/record/170661