Search results for "Database"

PCA and QSAR/QSPR used in combination to predict the drugs mechanism of action. An application to the NCI ACAM Database

2008

Data granularity in mid-year life table construction

2020

[EN] Life tables have a substantial influence on both public pension systems and life insurance policies. National statistical agencies construct life tables from death rate estimates (𝑚���𝑥���), or death probabilities (𝑞���𝑥��� ), after applying various hypotheses to the aggregated figures of demographic events (deaths, migrations and births). The use of big data has become extensive across many disciplines, including population statistics. We take advantage of this fact to create new (more unrestricted) mortality estimators within the family of period-based estimators, in particular, when the exposed-to-risk population is computed through mid-year population estimates. We use actual d…

Strategies for annotation and curation of translational databases: the eTUMOUR project

2012

Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-gene…

Perinatal Database in Germany

1995

By collecting standardized data from up to 600,000 deliveries per year in Germany a nation-wide database has been established in recent years enabling not only regional and overregional quality control, but also the scientific analysis of rare maternal and fetal complication. During the observation period of 10 years the understanding of perinatal risk factors has considerably improved and the perinatal mortality has declined from 9.4 to 6.4 (per 1,000 deliveries). From the huge amount of calculations typical results are presented.

The EDNAP mitochondrial DNA population database (EMPOP) collaborative exercises: organisation, results and perspectives.

2003

This paper presents an overview of the organisation and the results of the collaborative exercises (CE) of the European DNA Profiling (EDNAP) Group's mitochondrial DNA population database project (EMPOP). The aim of the collaborative exercises was to determine whether uniformity of mtDNA sequencing results could be achieved among different laboratories. These were asked to sequence either the complete mtDNA control region or the two hypervariable regions HVI (16024-16365) and HVII (73-340) from DNA extracts, buccal swabs or bloodstains, proceeding in accordance with the protocol and strategies used in each individual laboratory. The results of the collaborative exercises were employed to id…

Development of an Italian RM Y-STR haplotype database: Results of the 2013 GEFI collaborative exercise.

2015

Recently introduced rapidly mutating Y-chromosomal short tandem repeat (RM Y-STR) loci, displaying a multiple-fold higher mutation rate relative to any other Y-STRs, including those conventionally used in forensic casework, have been demonstrated to improve the resolution of male lineage differentiation and to allow male relative separation usually impossible with standard Y-STRs. However, large and geographically-detailed frequency haplotype databases are required to estimate the statistical weight of RM Y-STR haplotype matches if observed in forensic casework. With this in mind, the Italian Working Group (GEFI) of the International Society for Forensic Genetics launched a collaborative ex…

Snapshots of a solid-state transformation: coexistence of three phases trapped in one crystal† †Electronic supplementary information (ESI) available:…

2016

Solvent extrusion leads to crystallographic–magnetic transition within a molecular complex via an intermediate that can be trapped and characterized.

A new method for data evaluation of small angle neutron scattering experiments and its application to amorphous polycarbonate

1981

The conformation of single chains in bulk polymer materials can be evaluated from coherent neutron scattering on mixtures of normal and deuterated polymers. It is shown that the single-chain structure factor can be also obtained from measurements of highly concentrated mixtures and the procedure of evaluation is described. The application to amorphous polycarbonate demonstrates the advantages of the method.

"Table 4" of "Probing the quantum interference between singly and doubly resonant top-quark production in $pp$ collisions at $\sqrt{s}=13$ TeV with t…

2019

The systematic uncertainty on the unfolded distribution as a function of minimax-mbl, broken down by components.

Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones

2014

Protozoan parasites have been one of the most significant public health problems for centuries and several human infections caused by them have massive global impact. Most of the current drugs used to treat these illnesses have been used for decades and have many limitations such as the emergence of drug resistance, severe side-effects, low-to-medium drug efficacy, administration routes, cost, etc. These drugs have been largely neglected as models for drug development because they are majorly used in countries with limited resources and as a consequence with scarce marketing possibilities. Nowadays, there is a pressing need to identify and develop new drug-based antiprotozoan therapies. In …