Search results for "Databases"
showing 10 items of 937 documents
Evaluation of atezolizumab immunogenicity: Efficacy and safety (Part 2).
2022
Abstract Antibody therapeutics can be associated with unwanted immune responses resulting in the development of anti‐drug antibodies (ADA). Optimal methods to evaluate the potential effects of ADA on clinical outcomes in oncology are not well established. In this study, we assessed efficacy and safety, based on ADA status, in patients from over 10 clinical trials that evaluated the immune checkpoint inhibitor atezolizumab as a single agent or as combination therapy for several types of advanced cancers. ADA can only be observed post randomization, and imbalances in baseline prognostic factors can confound the interpretation of ADA impact. We applied methodology to account for the confoundin…
Ontology mapping specification in description logics for cooperative systems
2006
Le developpement rapide du Web semantique est lie a la specification de plus en plus d'ontologies. Celles-ci permettent de modeliser des connaissances agreees par des communautes de personnes concernant des domaines ou des tâches specifiques. Le meme domaine decrit par deux communautes distinctes sera modelise de facon differente. Les systemes cooperatifs visent a rendre les informations provenant de differentes sources disponibles au-dela de leurs divergences. Pour cela, ils doivent aligner, fusionner ou integrer ces ontologies. La decouverte de mappings est un point cle dans la resolution efficace des heterogeneites entre ontologies. Nous developpons une architecture qui connecte des syst…
Simple high-resolution wavelength monitor based on a fiber Bragg grating
2004
A compact and low-cost device for monitoring the peak wavelength of single-peak spectral distributions is presented. The system is based on the transmission properties of a fiber Bragg grating when its period is modulated. Different types of optical signal, such as the emission of distributed-feedback lasers and the reflection of a broadband optical source produced by fiber gratings used in sensor systems, can be measured with this device. We demonstrate that a high wavelength resolution of micro 1 pm can be achieved and that our proposal can be used for real-time monitoring.
An international perspective on hospitalized patients with viral community-acquired pneumonia
2019
Background Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results 553 (14.9%) patients with CAP underwent nasal swab. Viral CA…
Wykorzystanie zasobów baz danych GIS na potrzeby analizy zróżnicowania obszarów wiejskich w aspekcie działań PROW = Application of GIS databases for …
2018
Realizacja działań w ramach Programu Rozwoju Obszarów Wiejskich (PROW) wymaga obiektywnego rozpoznania potrzeb ich wdrażania, w oparciu o wyniki analiz złożonych procesów przyrodniczych i ekono- miczno-demograficznych zachodzących w czasie i przestrzeni obszarów wiejskich. Wzrastająca funkcjonalność Systemów Informacji Geograficznej (GIS) oraz powszechna dostępność do informacji przestrzennej spowodowały, że bazy danych GIS i analizy geoprzestrzenne stały się skutecznym narzędziem wpierającym implementację działań PROW. Celem pracy jest przedstawienie możliwości wykorzystania danych geoinformacyjnych wybranych baz danych GIS do analizy zróżnicowania przestrzennego obszarów wiejskich wojewód…
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
2015
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining a global resource. We identify 112 candidate ciliogenesis and ciliopathy genes, including 44 components of the ubiquitin-proteasome system, 12 G-protein-coupled receptors, and 3 pre-mRNA processing factors (PRPF6, PRPF8 and PRPF31) mutated in autosomal dominant retinitis pigmentosa. The PRPFs localize to the connecting cilium, and PRPF8- and PRPF31-mutated cells have ciliary defects. Combining the screen with exome sequen…
Wikipedia network analysis of cancer interactions and world influence
2019
AbstractWe apply the Google matrix algorithms for analysis of interactions and influence of 37 cancer types, 203 cancer drugs and 195 world countries using the network of 5 416 537 English Wikipedia articles with all their directed hyperlinks. The PageRank algorithm provides the importance order of cancers which has 60% and 70% overlaps with the top 10 cancers extracted from World Health Organization GLOBOCAN 2018 and Global Burden of Diseases Study 2017, respectively. The recently developed reduced Google matrix algorithm gives networks of interactions between cancers, drugs and countries taking into account all direct and indirect links between these selected 435 entities. These reduced n…
Contribution of Anales de Pediatría to the international visibility of Spanish paediatric research in the Web of Science (2010–2014)
2016
Objective: To describe the role of Anales de Pediatría in highlighting Spanish paediatric research, and to identify the journals with which it competes internationally. Material and method: Spanish paediatric articles, including those from Anales de Pediatría were identified using the Paediatrics category of the Science Citation Index (2010–2014), and their volume and document type was analysed. For original articles and review articles, the year, the citation and journal of publication was studied. The journals were classified as general and specialised. The productivity of general journals was analysed according to their language, JCR quartile, and article access. Results: A total of 2701…
Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria?
2021
Background and purpose The aim was to identify the clinical and diagnostic investigations that may help to support a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients not fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS) electrodiagnostic criteria. Methods The data from patients with a clinical diagnosis of CIDP included in a national database were retrospectively reviewed. Results In all, 535 patients with a diagnosis of CIDP were included. This diagnosis fulfilled the EFNS/PNS criteria in 468 patients (87.2%) (definite in 430, probable in 33, possible in three, while two had chronic immune sensory p…
Cost-Effectiveness Analysis: Stress Ulcer Bleeding Prophylaxis with Proton Pump Inhibitors, H2 Receptor Antagonists
2012
Abstract Objectives Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) present varying pharmacological efficacy in preventing stress ulcer bleeding (SUB) in intensive care units. The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options. Methods We constructed a decision tree with a 60-day time horizon for patients at high risk for developing SUB, receiving either PPIs or H2RAs. For each treatment strategy, patients could be in one of three states of health: SUB, VAP, or no complication. Contemporary, clinically relevant probabilit…