Search results for "Defence"

showing 10 items of 472 documents

Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Intra-party heterogeneity in policy preferences and its effect on issue salience: Developing and applying a measure based on elite survey data

2017

Quantitative research on party politics often has to assume that parties are unitary actors with homogeneous policy preferences simply because intra-party heterogeneity is difficult to measure. This article proposes a measure of preference heterogeneity based on surveys of party elites. We draw on Comparative Candidates Survey (CCS) data from 28 elections in 21 developed democracies to quantify intra-party heterogeneity and validate this measure. The usefulness of the measure is demonstrated by studying the effects of intra-party heterogeneity on issue salience. We find support for the hypothesis that heterogeneity regarding a policy issue tends to be negatively associated with the emphasi…

Manifesto021110 strategic defence & security studiesMeasure (data warehouse)Sociology and Political SciencePublic economicsSalience (language)media_common.quotation_subject05 social sciences0211 other engineering and technologies02 engineering and technologyUnitary state0506 political sciencePoliticselite surveys ideology intra-party heterogeneity issue attention party positionsddc:320Elite050602 political science & public administrationEconomicsSurvey data collectionIdeologySocial psychologymedia_commonParty Politics
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Macroelement Model for In-Plane and Out-of-Plane Responses of Masonry Infills in Frame Structures

2018

A new macroelement model is presented in this paper for the simulation of the in-plane (IP) and out-of-plane (OOP) response of infilled frames subjected to seismic actions. The model consists of two diagonal, one horizontal, and one vertical struts. Each strut is represented by two fiber-section beam-column elements. The model is able to capture the arching action of the wall under an OOP load as well as the interaction between the IP and OOP actions. The proposed modeling approach is sufficiently simple and efficient that it can be used for the static or dynamic analysis of an entire structural system. An experimental validation has been carried out. A further numerical study performed wit…

Masonry infillConcrete and masonry structure0211 other engineering and technologies020101 civil engineering02 engineering and technologyCivil Engineering0201 civil engineeringConcrete and masonry structuresOut of planeOut-of-planeMechanics of MaterialGeneral Materials ScienceArching actionCivil and Structural Engineering021110 strategic defence & security studiesMasonry infillsbusiness.industryMechanical EngineeringFrame (networking)In-planeBuilding and ConstructionStructural engineeringMaterials EngineeringMasonryFiber-section elementInfilled framesSettore ICAR/09 - Tecnica Delle CostruzioniIn planeMechanics of MaterialsMasonry infills; In-plane; Out-of-plane; Arching action; Macromodel; Fiber-section elements; Concrete and masonry structures.Materials Science (all)businessFiber-section elementsGeologyMacromodel
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Discontinuous FRP-Confinement of Masonry Columns

2020

Recent seismic events, all over the world, demonstrated that masonry constructions are prone to brittle collapses when shear or compression capacity is reached. It is clear that, in many real cases, masonry columns need to be strengthened for enhancing their load-carrying capacity and to develop a more ductile response. The Fiber Reinforced Polymers (FRPs) confinement of masonry columns is a well-known technique that may produce these advantages. Unfortunately, full-wrapping insulates the column from the environment; so interstitial humidity can easily occur and cause the acceleration of the masonry's decay. In order to prevent it, partial-confinement is commonly assessed instead of total-j…

Materials scienceGeography Planning and Development0211 other engineering and technologies020101 civil engineering02 engineering and technologySTRIPS0201 civil engineeringlaw.inventionlcsh:HT165.5-169.9BrittlenesslawStrain gaugediscontinuous confinementParametric statistics021110 strategic defence & security studiesanalysis-oriented modelbusiness.industryStructural engineeringEpoxyBuilding and Constructionlcsh:City planningFibre-reinforced plasticMasonrytestingUrban StudiesShear (geology)lcsh:TA1-2040visual_artconfinementvisual_art.visual_art_mediumlcsh:Engineering (General). Civil engineering (General)businessFRP
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Lessons Learned on the Tensile and Bond Behavior of Fabric Reinforced Cementitious Matrix (FRCM) Composites

2020

Fabric Reinforced Cementitious Matrix (FRCM) composites represent an effective, compatible and cost-efficient solution for strengthening and retrofitting existing structures. A strong research effort was done to investigate the tensile and bond properties of these materials, as well as the overall behaviour of strengthened members. A Round Robin Test was organized by Rilem TC 250-CSM on 28 FRCM composites comprising basalt, carbon, glass, PBO, aramid and steel textiles, embedded in either cement, lime or geopolymer mortars, to collect an experimental dataset and define test protocols. This paper collects the outcomes of this study to highlight fundamental properties of FRCM and to investiga…

Materials scienceGeography Planning and Development0211 other engineering and technologies020101 civil engineering02 engineering and technologytensile tests0201 civil engineeringlcsh:HT165.5-169.9shear bond testsUltimate tensile strengthmedicineretrofitting; round robin test (RRT); shear bond tests; steel reinforced grout (SRG); strengthening; tensile tests; textile reinforced mortar (TRM)Composite materialCement021110 strategic defence & security studiesBond strengthretrofittingStiffnessBuilding and Constructionlcsh:City planningtextile reinforced mortar (TRM)Urban StudiesGeopolymerAramidlcsh:TA1-2040strengtheninground robin test (RRT)Round robin testRetrofitting Round Robin Test (RRT) Steel Reinforced Grout (SRG) Strengthening Shear bond tests Textile Reinforced Mortar (TRM) Tensile testsmedicine.symptomMortarlcsh:Engineering (General). Civil engineering (General)steel reinforced grout (SRG)
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Constitutive Numerical Model of FRCM Strips Under Traction

2020

In this paper, the tensile behavior of Fiber Reinforced Cementitious Matrix (FRCM) strips is investigated through Finite Element (FE) models. The most adopted numerical modeling approaches for the simulation of the fiber-matrix interface law are described. Among them, the cohesive model is then used for the generation of FE models which are able to simulate the response under traction of FRCM strips tested in laboratory whose results are available in the technical literature. Tests on basalt, PBO and carbon coated FRCM specimens are taken into account also considering different mechanical ratios of the textile reinforcement. The comparison between FE results and experimental data allows val…

Materials scienceGeography Planning and DevelopmentTraction (engineering)0211 other engineering and technologiesNumerical modelingFRCM tensile behavior numerical modeling experimental tests interface modeling020101 civil engineering02 engineering and technologySTRIPSFRCM0201 civil engineeringlaw.inventionlcsh:HT165.5-169.9lawUltimate tensile strengthmedicinetensile behaviorComposite material021110 strategic defence & security studiesStiffnessexperimental testsBuilding and Constructionlcsh:City planningFinite element methodUrban StudiesTensile behaviornumerical modelinglcsh:TA1-2040experimental tests; FRCM; interface modeling; numerical modeling; tensile behaviorFe modelmedicine.symptominterface modelinglcsh:Engineering (General). Civil engineering (General)Frontiers in Built Environment
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Numerical Modeling Approaches of FRCMs/SRG Confined Masonry Columns

2019

The Fabric Reinforced Cementitious Matrices (FRCMs) and Steel Reinforced Grout (SRG) are a promising strengthening solution for existing masonry since inorganic matrix is considerably compatible with historical substrates. The present paper is focused on a Finite Element (FE) analysis of masonry columns confined with FRCM composites developed by Abaqus-code. The masonry columns were modelled using a macro model approach. The model was performed by using the following functions Concrete Damage Plasticity (CDP) and the Plastic (P) in order to describe the constitutive laws of material for masonry columns and external reinforcement, respectively. Typical failures of FRCM-systems are slippage o…

Materials sciencemasonry columnsGeography Planning and Development0211 other engineering and technologiesfabric/matrix bond020101 civil engineering02 engineering and technologyengineering.material0201 civil engineeringFRCM systemslcsh:HT165.5-169.9Matrix (mathematics)Overlap zone021110 strategic defence & security studiesbusiness.industryGroutBuilding and ConstructionStructural engineeringMasonrylcsh:City planningFinite element methodUrban Studiesnumerical modelinglcsh:TA1-2040confinementengineeringCementitiousSlippagebusinesslcsh:Engineering (General). Civil engineering (General)Failure mode and effects analysisFrontiers in Built Environment
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THE ATTITUDE OF THE PEDAGOGICAL SPECIALITIES’ STUDENTS OF THE UNIVERSITY OF LATVIA TO THE STUDY COURSE OF CIVIL DEFENCE

2020

In Latvia the Civil Defence course is a compulsory course for all higher education study programs. The aim of the study was to find out the attitude of the students of pedagogy specialties of the University of Latvia towards the Civil Defence course, to study the students' self-assessment of understanding the most important topics of the Civil Defence course and the most important insights learned by students during acquiring the Civil Defence course. To find out the attitude of the pedagogical specialties students towards the Civil Defence course, a questionnaire of the first-year students was carried out after the acquisition of the course. The responses of full-time and part-time student…

Medical educationCivil defensePolitical sciencecivil defence; full-time students; national defence; part-time students; study courseCourse (navigation)SOCIETY. INTEGRATION. EDUCATION. Proceedings of the International Scientific Conference
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Birth of the Biscane

2017

This paper describes the unprecedented storm Stephanie, which exhibited tropical characteristics over the Bay of Biscay on 15 September 2016. Remote sensing observations reveal a cloud-free area surrounded by a circular precipitation pattern and an axisymmetric wind field, while buoy observations show an abrupt drop in wind speed during the passage of the storm centre. Model analysis further corroborates an ongoing tropical transition from a frontal cold-core to a symmetric warm-core system. By analogy with ‘Medicanes’ (Mediterranean hurricanes), we name this storm a ‘Biscane’ (Biscay hurricane). Weather systems of this kind may become more frequent in a warmer climate.

Mediterranean climate021110 strategic defence & security studiesAtmospheric Science010504 meteorology & atmospheric sciencesBuoy0211 other engineering and technologiesWind fieldStorm02 engineering and technology01 natural sciencesWind speedEarth sciencesClimatologyddc:550BayGeology0105 earth and related environmental sciences
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Spatio-temporal distribution of microplastics in a Mediterranean river catchment: The importance of wastewater as an environmental pathway.

2021

Abstract Microplastics (MPs) are considered to be ubiquitous contaminants in freshwater ecosystems, yet their sources and pathways at the river catchment scale need to be better determined. This study assessed MP (55–5000 µm) pollution in a Mediterranean river catchment (central Spain) and aimed to identify the importance of wastewater as an environmental pathway. We sampled treated and untreated wastewaters, and raw and digested sludge from five WWTPs during two seasons. River water and sediments were sampled at three locations with different anthropogenic influences during three seasons. On average, 93% (47–99%) of MPs were retained by WWTPs. Concentrations in river water and sediment ran…

Mediterranean climatePollutionMicroplasticsEnvironmental EngineeringHealth Toxicology and Mutagenesismedia_common.quotation_subjectMicroplastics0211 other engineering and technologiesDrainage basin02 engineering and technology010501 environmental sciencesWastewater01 natural sciencesFreshwater ecosystemmedicineEnvironmental ChemistryWaste Management and DisposalEcosystem0105 earth and related environmental sciencesmedia_common021110 strategic defence & security studiesgeographygeography.geographical_feature_categorySedimentQ Science (General)Seasonalitymedicine.diseasePollutionWastewaterEnvironmental chemistryEnvironmental sciencePlasticsWater Pollutants ChemicalEnvironmental MonitoringJournal of hazardous materials
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