Search results for "Delivery"

showing 10 items of 1271 documents

Uptake of poly(2-hydroxypropylmethacrylamide)-coated gold nanoparticles in microvascular endothelial cells and transport across the blood-brain barri…

2020

The facile and modular functionalization of gold nanoparticles makes them versatile tools in nanomedicine, for instance, photothermal therapy, contrast agents or as model nanoparticles to probe drug-delivery mechanisms. Since endothelial cells from various locations in the body exhibit unique phenotypes we quantitatively examined the amount of different sized poly(2-hydroxypropylmethacrylamide)-coated gold nanoparticles internalized into primary human dermal endothelial cells or human brain endothelial cells (hCMEC/D3) by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and visualized the nanoparticles using light and electron microscopy. Poly(2-hydroxypropylmethacrylamide)…

TPChemistryBiomedical EngineeringDrug delivery to the brainNanoparticleProtein CoronaNanotechnologyPhotothermal therapyBlood–brain barrierQPR1medicine.anatomical_structureColloidal goldDrug deliverymedicineBiophysicsNanomedicineGeneral Materials ScienceBiomaterials science
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THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.

2012

Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…

Targeted drug delivery systemsSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSolid lipid nanoparticleNanostructured lipid carrierBlood-brain barrier
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Citizen-Patient Involvement in the Development of mHealth Technology: Protocol for a Systematic Scoping Review

2020

Background The development of mobile technology for information retrieval and communication, both at individual and health organizational levels, has been extensive over the last decade. Mobile health (mHealth) technology is rapidly adapting to the health care service contexts to improve treatment, care, and effectiveness in health care services. Objective The overall aim of this scoping review is to explore the role of citizen-patient involvement in the development of mHealth technology in order to inform future interventions. By identifying key characteristics of citizen-patient involvement in system development, we aim to improve digital communication and collaboration between health ca…

Telemedicine020205 medical informaticsperson-centeredComputer applications to medicine. Medical informaticsR858-859.7MEDLINE02 engineering and technologyCINAHLMHealthsystem developmentHealth informatics03 medical and health sciences0302 clinical medicineHealth care0202 electrical engineering electronic engineering information engineeringeHealthProtocolDelivery of health caremedical informaticsMobile technology030212 general & internal medicinemHealthcommunity-based participatory research:Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 [VDP]Medical education:Medisinske Fag: 700::Helsefag: 800 [VDP]Community-based participatory researchbusiness.industrydelivery of health careCommunity participationRGeneral MedicineTelemedicineSystem developmentmHealthMedical informaticsVDP::Medisinske Fag: 700::Helsefag: 800::Sykepleievitenskap: 808MedicineeHealthPatient participationtelemedicinePerson-centeredpatient participationcommunity participationbusinessPsychologyJMIR Research Protocols
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Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

The increasing interest in Graphene oxide (GO) is due to many issues: the presence of both sp2-conjugated atoms and oxygen-containing functional groups provides a strong hydrophilicity and the possibility to further functionalize it with other molecules (i.e. π-π interactions covalent attachment etc.) [1]. Furthermore since the GO is biocompatible and noncytotoxic many studies have been recently focused on the development of GO-based nanodevices for bioimaging DNA detection drug delivery. Due to their low cytotoxicity and large internal surface area silica nanoparticles have been taken into account as promising material for biolabeling and drug loading/delivery. Particular consideration has recently been demonstrated for GO-silica composites because of the potentialities for electrical applications their chemical inertia and stability toward ions exposure. The possibility to combine the extraordinary properties of GO and silica offers several advantages for the realization of nanoprobes for biological applications and of biosensor [12]. The strategy for the fabrication of GO-nanosilica nanohybrids can be schematized as follows: (i) synthesis of GO by oxidizing graphite powder with the method described by Marcano et al. [3] (ii) Preparation of oxygen-loaded silica nanoparticles by thermal treatments in controlled atmosphere in order to induce high NIR emission at 1272 nm from high purity silica nanoparticles. (iii) preparation of GrO-silica nanohybrid films via rapid solvent casting in water. The nanohybrids were tested by XPS FTIR Raman analysis UV photoluminescence analysis TGA Zeta potential measurements electrical tests AFM and SEM. Several nanohybrids were prepared by combining two different typologies of GO and two different samples of silica.
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Interventistica eco-guidata per l’articolazione d’anca

2013

Lo scopo di questo lavoro è di rivedere le principali applicazioni della interventistica eco-guidata d’anca, descrivendone le indicazioni e la metodologia. L’ecografia è una metodica considerata sicura per i pazienti, in quanto non è stato dimostrato un possibile danno dovuto all’energia trasmessa dagli ultrasuoni ai tessuti del paziente, contrariamente alle metodiche che fanno uso di radiazioni ionizzanti, come la radiografia convenzionale e la tomografia computerizzata. Inoltre, l’ecografia risulta rapida ed efficace nel guidare l’ago verso la sede voluta evitando di intercettare strutture vascolari e/o nervose, consentendo quindi una maggiore sicurezza, rispetto alle tecniche interventis…

The purpose of this work is to review the main applications of ultrasound-guided hip intervention al procedures describing the indications and methodology. Ultrasound is a method considered safe for patients as it has not been shown a possible damage due to ultrasound energy transmitted towards the patient's tissues as opposed to methods that make use of ionizing radiation such as conventional radiography and computed tomography. In addition ultrasound is quick and effective in guiding the needle to the desired location avoiding vascular and/or nerve structures thus enabling greater security compared to the techniques performed in interventional fluoroscopy which also have the disadvantage of a large delivery of ionizing radiation for both patient and operator. Several authors have described the main techniques of ultrasound-guided hip intervention and its various applications that can be both diagnostic (as in the case of joint fluid aspiration to assess the presence or absence of septic arthritis) and therapeutic (as in the case of drugs inoculations or evacuation of exceeding intra-articular fluid).
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Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment

2019

In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4&rsquo

Thermogravimetric analysisGeneral Chemical EngineeringNanoparticle02 engineering and technologyArticletrans-resveratrol derivativelcsh:Chemistry03 medical and health sciencesDynamic light scatteringX-ray photoelectron spectroscopygliomaZeta potentialMoleculeGeneral Materials Science[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics030304 developmental biologyiron oxide superparamagnetic nanoparticles0303 health sciencesChemistry<i>trans</i>-resveratrol derivativefood and beverages021001 nanoscience & nanotechnology3. Good healthMembranelcsh:QD1-999Drug deliverydrug delivery0210 nano-technologyNuclear chemistryNanomaterials
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PHEA-graft-polybutylmethacrylate copolymer microparticles for delivery of hydrophobic drugs.

2012

Abstract Polymeric microparticles encapsulating two model hydrophobic drugs, beclomethasone dipropionate (BDP) and flutamide (FLU) were prepared by using the high pressure homogenization-solvent evaporation method starting from a oil-in-water emulsion. For the preparation of polymeric microparticles a α,β-poly(N-2-hydroxyethyl)- d , l -aspartamide (PHEA) graft copolymer with comb like structure was properly synthesized via grafting from atom transfer radical polymerization (ATRP) technique, by using two subsequent synthetic steps. In the first step a polymeric multifunctional macroinitiator was obtained by the conjugation of a proper number of 2-bromoisobutyryl bromide (BIB) residues to the…

Time FactorsBioadhesivePharmaceutical ScienceCell LineDrug Delivery SystemsPolymethacrylic AcidsPolymer chemistryMucoadhesionCopolymerSide chainHumansPhea polybutylmethacrylate microparticles drug deliveryParticle SizeGlucocorticoidsDrug CarriersDose-Response Relationship DrugChemistryAtom-transfer radical-polymerizationBeclomethasoneAdhesivenessAndrogen AntagonistsGraftingFlutamideMicrospheresPolymerizationDelayed-Action PreparationsEmulsionSolventsNanoparticlesEmulsionsCaco-2 CellsPeptidesHydrophobic and Hydrophilic InteractionsInternational journal of pharmaceutics
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A new biodegradable and biocompatible hydrogel with polyaminoacid structure

2007

The preparation and physicochemical and biological characterization of a novel polyaminoacid hydrogel have been reported. The ,-poly(N-2- hydroxyethyl)-dl-aspartamide (PHEA) has been used as a starting polymer for a derivatization reaction with methacrylic anhydride (MA) to give rise to the methacrylate derivative named PHM. Photocrosslinking of PHM has been performed in aqueous solution at 313 nm and in the absence of toxic initiators. PHM-based hydrogel has been characterized by scanning electron microscopy, X-ray diffractometry, swelling measurements in aqueous media; the degradation of PHM-based hydrogel has been evaluated as a function of time in the absence or in the presence of ester…

Time FactorsBiocompatibilityCell SurvivalSurface PropertiesChemistry PharmaceuticalPharmaceutical ScienceMethacrylic anhydrideBiocompatible MaterialsMicroscopy Atomic ForceMethacrylateDosage formchemistry.chemical_compoundPolymethacrylic AcidsX-Ray DiffractionSpectroscopy Fourier Transform InfraredPolymer chemistryHumansTechnology PharmaceuticalDrug CarriersAqueous solutionHydrolysisEsterasestechnology industry and agricultureWaterHydrogelshydrogels FT-IRBlood ProteinschemistrySelf-healing hydrogelsDrug deliveryMicroscopy Electron ScanningK562 CellsPeptidesDrug carrierPorosityProtein BindingNuclear chemistryInternational Journal of Pharmaceutics
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Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin

2021

Nanoparticles (NPs) have emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are still some controversial points which need a deeper understanding before clinical application can occur. Here the use of gold nanoparticles (AuNPs) to detoxify the antitumoral agent cisplatin, linked to a nanoparticle via a pH-sensitive coordination bond for endosomal release, is presented. The NP conjugate design has important effects on pharmacokinetics, conjugate evolution and biodistribution and results in an absence of observed toxicity. Besides, AuNPs present unique o…

Time FactorsCancer TreatmentMetal Nanoparticleslcsh:MedicinePharmacologyMiceNanotechnologyTissue Distributionlcsh:Sciencemedia_commonDrug DistributionDrug CarriersMultidisciplinaryChemistryDNA NeoplasmOrgan SizeHydrogen-Ion ConcentrationEndocytosisOncologyColloidal goldDrug deliveryInactivation MetabolicMedicinemedicine.drugResearch ArticleBiotechnologyDrugBiodistributionDrugs and Devicesmedia_common.quotation_subjectMaterials ScienceAntineoplastic AgentsMaterial by AttributePharmacokineticsCell Line TumormedicineAnimalsHumansPharmacokineticsBiologyNanomaterialsCisplatinUnited States Food and Drug Administrationlcsh:RChemotherapy and Drug TreatmentUnited StatesBionanotechnologylcsh:QGoldNanocarriersCisplatinConjugate
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SYNTHESIS, CHARACTERIZATION AND IN VITRO CYTOTOXICITY STUDIES OF A MACROMOLECULAR CONJUGATE OF PACLITAXEL BEARING OXYTOCIN AS TARGETING MOIETY.

2007

The present study describes the experimental synthetic procedure and the characterization of a new polyaspartamide macromolecular prodrug of paclitaxel, bearing oxytocin residues as targeting moieties. In vitro stability studies of bioconjugate, performed in media mimicking biological fluids (buffer solutions at pH 7.4 and 5.5) and in human plasma, evidenced the high stability of the targeting portion (oxytocin)-polymer linkage and the ability of this conjugate to release linked paclitaxel in a prolonged way in plasma. Moreover, preliminary in vitro antiproliferative studies, carried out on MCF-7 cells, that are oxytocin receptor positive cells, showed that the polymeric conjugate has the s…

Time FactorsChemistry PharmaceuticalDrug CompoundingpolyaspartamidePharmaceutical ScienceBreast NeoplasmsPolyethylene Glycolschemistry.chemical_compoundpaclitaxelDrug StabilityCell Line TumoroxytocinHumansMoietyProdrugsbioconjugateCytotoxicityCell ProliferationDrug CarriersDose-Response Relationship DrugMolecular StructureHydrolysisdrug targetingGeneral MedicineHydrogen-Ion ConcentrationAntineoplastic Agents PhytogenicOxytocin receptorIn vitroSolubilityPaclitaxelchemistryBiochemistryTargeted drug deliveryReceptors OxytocinDelayed-Action PreparationsFemalePeptidesDrug carrierBiotechnologyConjugate
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