Search results for "Delivery"
showing 10 items of 1271 documents
The European network for care of children with paediatric rheumatic diseases : Care across borders
2019
Objectives. To provide an overview of the paediatric rheumatology (PR) services in Europe, describe current delivery of care and training, set standards for care, identify unmet needs and inform future specialist service provision. Methods. An online survey was developed and presented to national coordinating centres of the Paediatric Rheumatology International Trials Organisation (PRINTO) (country survey) and to individual PR centres (centre and disease surveys) as a part of the European Union (EU) Single Hub and Access point for paediatric Rheumatology in Europe project. The survey contained components covering the organization of PR care, composition of teams, education, health care and …
Lipid phase transition in saccharide-coated cholate-containing liposomes: coupling to the surrounding matrix.
2005
We performed FTIR measurements on cholate-containing liposomes (CCL) embedded in saccharide (trehalose or sucrose) matrixes with different contents of residual water. We obtained information on the CCL phase transition following the thermal evolution (310-70 K) of the IR spectrum of the carbonyl moieties of phospholipids in the frequency range 4225-4550 cm(-1). Furthermore, we simultaneously followed the thermal evolution of the water association band, which gave information on the behavior of the surrounding water-saccharide matrix. The analysis revealed a small sub-band of the water association band present in CCL but not in cholate-free liposomes, the thermal evolution of which is tightl…
Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.
2015
During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further…
Five types of OECD healthcare systems: Empirical results of a deductive classification
2013
This article classifies 30 OECD healthcare systems according to a deductively generated typology by Rothgang and Wendt [1]. This typology distinguishes three core dimensions of the healthcare system: regulation, financing, and service provision, and three types of actors: state, societal, and private actors. We argue that there is a hierarchical relationship between the three dimensions, led by regulation, followed by financing and finally service provision, where the superior dimension restricts the nature of the subordinate dimensions. This hierarchy rule limits the number of theoretically plausible types to ten. To test our argument, we classify 30 OECD healthcare systems, mainly using O…
A versatile ultrasound system for in vitro experiments
2015
Objective One of the most difficult tasks to achieve with the available instrumentations used to study the interaction between ultrasound (US) and cellular model systems is to design an experiment, where only the effects of one physical parameter at a time is evaluated, while all the others are kept constant. The set-ups are usually custom-made, often by means of clinical instrument intended for a different therapeutic purpose. Furthermore, the results are not strictly comparable with others obtained with techniques considered standard in molecular and cellular biology at this time, because there is the need to use non-standard devices to contain biological samples. Sterility, as well as te…
Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3' UTRs Identified by Cellular Library Screening.
2019
Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it is being explored for a variety of therapeutic applications. Many of these applications require prolonged intracellular persistence of mRNA to improve bioavailability of the encoded protein. mRNA molecules are intrinsically unstable and their intracellular kinetics depend on the UTRs embracing the coding sequence, in particular the 3′ UTR elements. We describe here a novel and generally applicable cell-based selection process for the identification of 3′ UTRs that augment the expression of proteins encoded by synthetic mRNA. Moreover, we show, for two applications of mRNA therapeutics, namely, (1) …
From evidence-based to sustainable healthcare: Cochrane revisited
2022
Evidence-based healthcare is the prevailing model for healthcare services. In Cochrane's seminal thinking, political context was included with the purpose of promoting healthcare equity. However, the subsequent evidence-based healthcare models marginalized political context. In this paper, we argue that current models of evidence-based healthcare fail to respond to emerging healthcare challenges. We claim that reintegration of political context is crucial to make healthcare sustainable. Global communities are anticipating ecological crises with immense repercussions for healthcare. This prospect illustrates that healthcare models failing to integrate political context also risk neglecting s…
Balancing food waste and sustainability goals in online food delivery: Towards a comprehensive conceptual framework
2022
Increasing food waste is a major threat to sustainability and food security. Recognizing the issue, the United Nations Sustainable Development Goal (SDG) 12 mandates reducing global food waste by 50 percent by 2030. This situation has also given impetus to academic research on consumer food waste in both household and out-of-home settings. However, food delivery apps (FDAs) remain under-researched from this perspective. This is a serious gap because operating under a business model that inherently facilitates food over-ordering, FDAs can be a major source of food waste. Understanding the demand-side factors that drive consumers to order more food than required to satiate their hunger can be…
Improving on-time delivery at Aker Solutions : a case study of the Spare Parts division
2014
Masteroppgave i industriell økonomi og teknologiledelse IND 590 Universitetet i Agder 2014 The purpose of this thesis is to present possible solutions to how Aker Solutions’ Spare Parts division can improve their on-time delivery. This thesis is a case study that focuses mainly on the supply chain of the Spare Parts division and not the entire organization. Spare Parts’ main task is to provide spare parts to customers. The process of providing the spare parts can involve both internal and external factors. The internal processes include the Procurement division if the items aren’t on stock, and warehouse for picking and packing. The external processes include the suppliers that provide Aker…
Interneta veikala izstrāde
2019
Diplomdarba “Interneta veikala izstrāde” mērķis ir izveidot interneta veikalu ar nosaukumu “Olby”, kas pārdos apdrukātas preces ar interneta starpniecību un strādās izmantojot Latvijā pieejamos tiešās piegādes (Drop Shipping) pakalpojumus. Interneta veikals pārdos dažādus tekstilmateriālus, mājas dekorus, piederumus, kas būs drukāti ar termodrukas tehnoloģiju. Diplomdarbu sastāda sešas nodaļas. Pirmajā nodaļā aprakstīts par E-komercijas modeli un platformas raksturojums. Otrajā nodaļā pētīta konkurentu analīze. Trešajā nodaļā veikta prasību noteikšana. Ceturtajā nodaļā pētītas un salīdzinātas e-komercijas platformas. Piektajā nodaļā aprakstīts veikala prototips. Sestajā nodaļā aprakstīts pr…