Search results for "Delivery"

Hyaluronic acid based hydrogels for antibiotics and enzymes release: from academic research to industry

2016

Conclusion: HA-g-PDLLA hydrogel is suitable to coat a prosthesis remaining adherent to it and distributing itself in the bone cavity. The hydrogel has been proven effective in a rabbit model of highly contaminated implant. In vivo studies have demonstrated how the intraoperative coating of implants with DAC is safe and feasible. HA-EDA-MA hydrogel is able to protect PEP from alteration during storage and it seems a good candidate for a potential once-daily oral formulation in the treatment of celiac disease.

Production of hyaluronic acid derivative microfibers with controlled dimension as potential drug delivery system

2015

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

2014

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…

Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules

2016

A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation. The nanohybrid was employed for concurrent load and release of silibinin and curcumin. The new delivery system was characterized by means of TGA, FT-IR spectroscopy, SEM and DLS. These techniques confirm the successful loading of the two drugs in the system. SEM and DLS measurements highlighted that the nanomaterial preserves a tubular structure with an average hydrodynamic radius of ca. 200 nm. The release of the drugs from the HNT glycocluster was investigated by means of UV-vis spectro…

Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

2017

tar-like polymers are one of the smallest systems in the class of core crosslinked polymeric nanoparticles. This article reports on a versatile, straightforward synthesis of three-arm star-like polypept(o)ide (polysarcosine-block-polylysine) polymers, which are designed to be either stable or degradable at elevated levels of glutathione. Polypept(o)ides are a recently introduced class of polymers combining the stealth-like properties of the polypeptoid polysarcosine with the functionality of polypeptides, thus enabling the synthesis of materials completely based on endogenous amino acids. The star-like homo and block copolymers are synthesized by living nucleophilic ring opening polymerizat…

Macromolecular engineering of hydrogels: from macro to nano scalar materials for different levels of biointeraction

2009

Testing the long term applicability of USLE-M equation at a olive orchard microcatchment in Spain

2016

Abstract Universal Soil Loss Equation USLE-based erosion models have been used extensively to complement erosion measurements, to understand the interactions of the different geophysical features into erosion processes and to assess adequate alternative management practices and scenarios analyses. Despite its proved usefulness on different land-uses around the world, there is an urgent need to set up simple tools which do not require an advanced management expertise in terms of both choose of model parameters and calculation ability and which are accurate particularly at the event scale. In this paper the suitability of the Modified USLE (USLE-M) model at the event and the annual scale were…

Evaluation of the SEDD model for predicting sediment yield at the Sicilian experimental SPA2 basin

2007

In this paper a spatially distributed model of the hillslope sediment delivery processes, named the sediment delivery distributed (SEDD) model, is initially reviewed; the model takes into account the sediment delivery processes due to both the hillslope sediment transport and the effects of slope curvature. Then the rainfall and sediment yield events measured at the experimental SPA2 basin, in Sicily, are used both to calibrate the SEDD model and to verify the predictive capability of the distributed sediment delivery approach at event scale. For the SPA2 basin discretized into morphological units and stream tubes, the SEDD model is calibrated at event scale using the measurements carried o…

Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization

2011

Polymer-coated liposomes, particularly poly(ethylene glycol) (PEG)-substituted liposomes, have emerged as long-circulating carrier systems for drug delivery and diagnostic purposes. A rapid synthesis of three different types of multifunctional lipids with structurally diverse hydrophilic, polyether-based architectures via one- or two-pot approaches is described. Architectural variation is achieved by the combination of different oxyanionic polymerization strategies and various glycidyl ether building units. Branched polyglycerol lipids have been prepared via cholesterol- or 1,2-bis-n-alkyl glyceryl ether-initiated, oxyanionic ring-opening polymerization (ROP) of protected glycidyl ethers an…

Site-specific halloysite functionalization by polydopamine: A new synthetic route for potential near infrared-activated delivery system

2022

Abstract Halloysite nanotubes (HNTs) represent a versatile core structure for the design of functional nanosystems of biomedical interest. However, the development of selective methodologies for the site-controlled functionalization of the nanotubes at specific sites is not an easy task. This study aims to accomplish a procedure for the site-selective/specific, “pin-point”, functionalization of HNTs with polydopamine (HNTs@PDA). This goal was achieved, at pH 6.5, by exploiting the basicity of ZnO nanoparticles anchored on the HNTs external surface (HNTs@ZnO) to induce a punctual polydopamine polymerization and coating. The morphology and the chemical composition of the nanomaterial was demo…