Search results for "Deme"
showing 10 items of 883 documents
Sensibilité des rendements agricoles potentiels aux paramètres climatiques et environnementaux dans la région du mont Kenya en Afrique de l’Est.
2013
7 pages; International audience; Comprendre les interactions existantes entre le climat et les rendements céréaliers est un objectif important pour l'actuelleproduction agricole et la sécurité alimentaire future des populations résidant dans des régions à agriculture pluviale. Lesrendements potentiels de sorgho simulés par le modèle SARRAH montrent une sensibilité aux paramètres climatiques etenvironnementaux le long des pentes orientales du Mont Kenya. Si le cumul et la durée de saison expliquent une part importante dela variabilité des rendements, d’autres variables comme l’intensité quotidienne, les Tmax ou encore le rayonnement global jouentun rôle non négligeable. La date de semis modu…
Kernel estimation and display of a five-dimensional conditional intensity function
2018
The aim of this paper is to find a convenient and effective method of displaying some second order properties in a neighbourhood of a selected point of the process. The used techniques are based on very general high-dimensional nonparametric smoothing developed to define a more gen- eral version of the conditional intensity function introduced in earlier earthquake studies by Vere-Jones (1978). 1976) is commonly used for such a purpose in discussing the cumulative behavior of interpoint distances about an initial point. It is defined as the expected number of events falling within a given distance of the initial event, divided by the overall density (rate in 2-dimensions) of the process, sa…
People with memory illnesses and their spouses as actors in the hybrid care model
2023
Objective: The study analysed how its participants positioned themselves and other people as actors in daily life, and what matters they portrayed as meaningful in seeking and receiving support in daily life. Background: Family care has traditionally played an important role in elder care in Finland. Current policy goals will further increase the importance of family care, yet research on how people with memory illnesses and their spouses perceive care arrangements is scarce. Method: The study drew from theory of relational agency and positioning theory. The data came from semi-structured, in-depth interviews (10) of home-dwelling people diagnosed with a memory illness and their spouses. Th…
REM sleep behavior disorder in a patient with frontotemporal dementia
2010
We describe a patient with frontotemporal dementia (FTD), a tauopathy, who also showed clinical and polysomnographic features of REM sleep behavior disorder (RBD). The patient is a 78-year-old male with a 1 year history of behavioral dysfunction involving emotion, character and social functioning. Brain imaging and the results of neuropsychological testing were consistent with a diagnosis of FTD. Sleep symptom onset occurred some years before the behavioral changes, and consisted of unpleasant dreams, vocalization, and prominent motor behaviors. A polysomnography confirmed the diagnosis of RBD. Our findings support the hypothesis that RBD, although more frequent in synucleinopathies, might …
Les effets conjugués de la gestion parcellaire et du contexte paysager et de sa dynamique sur les bioagresseurs et les niveaux de régulation biologiq…
2017
International audience; De nombreux travaux ont mis en évidence que les caractéristiques du paysage environnant les parcelles agricoles influencent les abondances d’ennemis naturels et le niveau de régulation biologiquedans les cultures. Les effets du paysage sur l’abondance de bio-agresseurs sont par contre encore peu étudiés. Les effets du paysage sur la régulation biologique sont parfois contradictoires, souventspécifiques aux sites et de ce fait encore peu généralisables. Des travaux récents suggèrent que ces variations de réponse peuvent résulter d’interactions entre gestion parcellaire et contexte paysager,avec des effets conditionnels du paysage selon le type de gestion parcellaire e…
Dietary Patterns and Healthy Ageing
2021
Ageing is a complex process in which multiple factors are involved that can contribute to determine whether a person will or not be affected by diseases that are more frequently observed in advanced age. The factors involved comprise genetic, environmental, behavioural, and dietary factors, which influence pathways that regulate the ageing process and the life expectancy, rendering longevity a multifaceted phenomenon. Even if a miraculous elixir or pill is not yet available, there is general agreement that nutrition has a major impact on the overall mortality and on the development of age-related chronic non-communicable diseases. Nutrition research has focused for decades on single nutrien…
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair
2015
Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …
Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia
1992
Abstract In this randomized double-blind, placebo controlled, multicentre study on 108 elderly patients with mild to moderate mental deterioration of vascular origin, idebenone — a benzoquinone derivative with a hydroxyalkyl side chain — proved to be therapeutically effective in the treatment of multi-infarct dementia. The oral administration of idebenone 45 mg/day b.i.d. for 120 days significantly improved the scores of the following test in comparison with placebo: Mini Mental State, Randt Memory Test, Gottfries Rating Scale, Token Test, Toulouse Pieron Test, indicating improvements in memory attention and cognitivity. The drug was well tolerated and effective in patients with multi-infar…
From obesity to Alzheimer's disease through insulin resistance
2021
Alzheimer's disease is one of the most frequent forms of dementia. It is a progressive neurodegenerative disease, characterized by presence of amyloid plaques and neurofibrillary tangles in the brain. Obesity is regarded as abnormal fat accumulation with deleterious impact on human health. There is full scientific evidence that obesity and the metabolic comorbidities (e.g., insulin resistance, hyperglycaemia, and type 2 diabetes) are related to Alzheimer's disease and likely in the causative pathway. Numerous studies have identified several overlapping neurodegenerative mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammation. In this review, we present how obesit…
Effect of antibodies against cytochrome P-450 on demethylation and denitrosation of N-nitrosodimethylamine and N-nitrosomethylaniline.
1988
Rat liver microsomes which were induced either with ethanol or PB were incubated with NDMA or NMA. Formaldehyde generation and nitrite formation were measured as metabolic parameters for oxidative bioactivation and denitrosation, respectively. The influence of antiserum PB3a1 and PB22 containing antibodies against the corresponding cytochrome P-450 species on both metabolic functions was investigated. The results showed that the influence on formaldehyde production and denitrosation varied independently in that both parameters were either not affected, or influenced in an opposite way, or inhibited to a different degree. Especially remarkable was the 80% inhibition of formaldehyde generatio…