Search results for "Deme"

Patterns of genomic instability in gastric cancer: clinical implications and perspectives

2007

In gastric cancer (GC) the loss of genomic stability represents a key molecular step that occurs early in the carcinogenesis process and creates a permissive environment for the accumulation of genetic and epigenetic alterations in tumor suppressor genes and oncogenes. It is widely accepted that GC can follow at least two major genomic instability pathways, microsatellite instability (MSI) and chromosome instability (CIN). MSI is responsible for a well-defined subset of GCs. CIN represents a more common pathway comprising heterogeneous subsets of GC. In addition to MSI and CIN, the CpG islands methylator phenotype (CIMP) plays an important role in gastric carcinogenesis. CIMP may lead to th…

Économétrie spatiale : l'autocorrélation spatiale dans les modèles de régression linéaire

2002

Spatial Econometrics : Automatic Spatial Correlation in Linear Regression Models. The aim of this article is to describe the tools necessary to factor in automatic spatial correlation determined by the absence of independence between geographical observations, within the framework of linear regression models. While it is often accepted that spatial data in cross-sections are independent, this assumption is rarely justified. On the contrary, it needs to be tested systematically. After explaining the ways in which to model automatic spatial correlation, we therefore describe estimation and inference procedures geared to econometric models that factor in this effect explicitly. Lastly, we prop…

Mercury in fishes from Augusta Bay (southern Italy): risk assessment and health implication

2013

Our study reports on the total mercury (HgT) concentrations measured in the muscles and livers of several benthic, demersal and pelagic fish species caught inside and outside of Augusta Bay (southern Italy), a semi-enclosed marine area, highly contaminated by the uncontrolled (since the 1950s to 1978s) discharge of the largest European petrochemical plant. Mercury levels in fish tissues are discussed with regard to specific habitat, size and/or age of the specimens and HgT distribution in the bottom sediments. Results suggest a still active Hg release mechanism from the polluted sediments to the marine environment. Also, the high HgT concentrations measured in fishes caught in the external …

Kotona asuvan muistisairaan henkilön ja hänen läheistensä teknologiaan liittyvät tarpeet ja toiveet

2018

Tutkimuksessa selvitettiin millaisia tarpeita ja toiveita kotona asuvilla muistisairailla ja heidän läheisillään on kotona asumista tukevaan teknologiaan liittyen. Tutkimukseen osallistui 25 kotona asuvaa muistisairasta henkilöä ja 25 heidän läheistään. Metodina käytettiin etnografista tutkimusotetta. Aineistonkeruumenetelminäolivat avoin haastattelua ja havainnointi. Analyysimenetelmänä käytettiin sisällön analyysiä. Tarpeet ja toiveet voitiin luokitella kolmeen pääluokkaan, jotka olivat itsemääräämisoikeuden säilyminen, sosiaalisten suhteiden säilyminen ja liikkumisen oikeus ja turvallisuus. Haasteita olivat yksinäisyyden kokemus, muistin ja toimintakyvyn heikkenemiseen liittyvät ongelmat…

Nutritional screening of patients at a memory clinic--association between patients' and their relatives' self-reports.

2015

Aims and objectives To compare individual reports by patients and relatives (proxy) of the Nutritional Form For the Elderly and relate the Nutritional Form For the Elderly scores to Mini Mental Status Examination scores, weight loss, Body Mass Index, five-point Clock Drawing Test and background variables. Background Undernutrition or risk of undernutrition is a significant problem among people with dementia. A poor nutritional state increases the risk of infections, delayed convalescence after acute illness and reduced quality of life. Design A cross-sectional study. Method Application of the Nutritional Form For the Elderly in addition to clinical nutrition parameters and cognitive tests i…

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIP…

2016

Introduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence abou…

Physical exercise in the prevention and treatment of Alzheimer's disease

2020

Highlights • Low levels of physical activity are a risk factor associated with Alzheimer's disease. • Older adults who exercise are more likely to maintain cognition. • Exercise modulates amyloid β turnover, inflammation, synthesis, and release of neurotrophins, and cerebral blood flow.

Dietary Patterns and Cognitive Decline: key features for prevention

2019

The decline in cognitive function is generally the result of the complex interaction of several factors. First of all, age, but also demographic, educational, genetic, socio-economic, and environmental determinants, including nutrition. Cognitive decline and dementia prevalence are increasing, and they are projected to continue increasing in the next decades due to the aging of the world population. Currently, there are no effective pharmacological treatments for these devastating and disabling conditions, which emphasize the key role of preventive strategies. There is compelling evidence of the role of diet and lifestyle on cognitive function. Therefore, dietary/ nutritional approaches th…

Impact of Physical Activity and Nutrition on Dementia: A Growing Consensus.

2020

Feriereise kan ha positiv innvirkning på pasienter med demenslidelse

2012

Published version of an article in the journal: Vård i Norden Aim. To gain knowledge about how a holiday trip to Spain with adapted cultural activities may affect a group of patients with dementia disorder. Background. With the increasing number of people suffering from dementia, it will be important to focus on activities that may affect well-beeing in this group. Method. A focus group interview was conducted with six healthcare workers, who participated in a trip to Spain together with six patients suffering from dementia. A qualitative content analysis was used. Findings. The findings were interpreted in one main theme: Close follow-up in unfamiliar environment and participation in adapt…