Search results for "Dengue"

THE JOURNALISTIC TREATMENT OF THE NEWS RELATED TO DENGUE AND ZIKA VIRUSES IN THE DIGITAL MEDIA OF HONDURAS (2010-2017)

2019

Resumen: En 1979, se identificó la primera epidemia de dengue en Honduras. En 2010, las autoridades sanitarias y gubernamentales hondureñas decretaron lo que sería la quinta epidemia que afectaba a la población. Cinco años más tarde, una enfermedad emergente llegó al continente americano: el zika. Las entidades internacionales como la Organización Mundial de la Salud y la Organización Panamericana de Salud extendieron la alerta a nivel latinoamericano, en especial a los países propensos por su situación geográfica, climatológica y situación socioeconómica. El objetivo del presente estudio es analizar el contenido de las noticias que se publicaron sobre los virus del dengue y zika en tres di…

Spatio-temporal analysis of infectious diseases

2018

Los sistemas de vigilancia de salud pública colectan y analizan datos que soportan los programas de control y prevención de enfermedades en todo el mundo. En Colombia, el sistema de vigilancia en salud pública (SIVIGILA) esta encargado del flujo de datos e información de la vigilancia de las enfermedades de notificación obligatoria que afectan la salud de los Colombianos. Las enfermedades transmitidas por mosquitos tales como el dengue, la malaria, la fiebre amarilla, la enfermedad del virus del Chikungunya, la enfermedad del virus del Zika (EVZ) entre otras afectan seriamente la salud de las poblaciones a través de todo el país. Dentro de estas enfermedades se destacan la enfermedad del de…

2020

Vector-borne diseases such as malaria, dengue fever, West Nile virus, and so forth are some of the most prominent threats to human health. They are transmitted to the human population by infected insects or by direct transmission between humans. The epidemic process relies on suitable environmental and climatic conditions. Indeed, climatic factors affect the development of pathogens in vectors as well as the population dynamics of the vectors impacting significantly the incidence of disease in the human population. While the influence of the climatic conditions on Vector-borne diseases is well-documented, there is a strong need to design more realistic epidemiological models incorporating e…

Relative risk estimation of dengue disease at small spatial scale

2017

Abstract Background Dengue is a high incidence arboviral disease in tropical countries around the world. Colombia is an endemic country due to the favourable environmental conditions for vector survival and spread. Dengue surveillance in Colombia is based in passive notification of cases, supporting monitoring, prediction, risk factor identification and intervention measures. Even though the surveillance network works adequately, disease mapping techniques currently developed and employed for many health problems are not widely applied. We select the Colombian city of Bucaramanga to apply Bayesian areal disease mapping models, testing the challenges and difficulties of the approach. Methods…

Vascular Leakage in Severe Dengue Virus Infections: A Potential Role for the Nonstructural Viral Protein NS1 and Complement

2006

Background Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown. Methods The major nonstructural dengue virus (DV) protein NS1 was tested for its capacity to activate human complement in its membrane-associated and soluble forms. Plasma samples from 163 patients with DV infection and from 19 patients with other febrile illnesses were prospectively analyzed for viral load and for levels of NS1 and complement-activation products. Blood and pleural fluids from 9 patient…

Two-level resolution of relative risk of dengue disease in a hyperendemic city of Colombia.

2018

Risk maps of dengue disease offer to the public health officers a tool to model disease risk in space and time. We analyzed the geographical distribution of relative incidence risk of dengue disease in a high incidence city from Colombia, and its evolution in time during the period January 2009—December 2015, identifying regional effects at different levels of spatial aggregations. Cases of dengue disease were geocoded and spatially allocated to census sectors, and temporally aggregated by epidemiological periods. The census sectors are nested in administrative divisions defined as communes, configuring two levels of spatial aggregation for the dengue cases. Spatio-temporal models including…

Joint Estimation of Relative Risk for Dengue and Zika Infections, Colombia, 2015–2016

2019

We jointly estimated relative risk for dengue and Zika virus disease (Zika) in Colombia, establishing the spatial association between them at the department and city levels for October 2015–December 2016. Cases of dengue and Zika were allocated to the 87 municipalities of 1 department and the 293 census sections of 1 city in Colombia. We fitted 8 hierarchical Bayesian Poisson joint models of relative risk for dengue and Zika, including area- and disease-specific random effects accounting for several spatial patterns of disease risk (clustered or uncorrelated heterogeneity) within and between both diseases. Most of the dengue and Zika high-risk municipalities varied in their risk distributio…

Could the recent zika epidemic have been predicted?

2017

AbstractGiven knowledge at the time, the recent 2015-2016 zika virus (ZIKV) epidemic probably could not have been predicted. Without the prior knowledge of ZIKV being already present in South America, and given the lack of understanding of key epidemiologic processes and long-term records of ZIKV cases in the continent, the best related prediction was for potential risk of an Aedes-borne disease epidemic. Here we use a recently published two-vector capacity model to assess the predictability of the conditions conducive to epidemics of diseases like zika, chikungunya or dengue, transmitted by the independent or concurrent presence of Aedes aegypti and Aedes albopictus. We compare the potenti…

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

2014

NS2B-NS3 is a serine protease of the Dengue virus considered a key target in the search for new antiviral drugs. In this study flavonoids were found to be inhibitors of NS2B-NS3 proteases of the Dengue virus serotypes 2 and 3 with IC50 values ranging from 15 to 44 μM. Agathisflavone (1) and myricetin (4) turned out to be noncompetitive inhibitors of dengue virus serotype 2 NS2B-NS3 protease with Ki values of 11 and 4.7 μM, respectively. Docking studies propose a binding mode of the flavonoids in a specific allosteric binding site of the enzyme. Analysis of biomolecular interactions of quercetin (5) with NT647-NHS-labeled Dengue virus serotype 3 NS2B-NS3 protease by microscale thermophoresis…

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

2021

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.