Search results for "Dengue"
showing 7 items of 37 documents
Multiple Linear Regression to predict larvicidal activity against <em>Aedes aegypti </em>mosquito
2017
Vector-borne diseases are one of the important health problems in most tropical countries. Aedes aegypti is an important vector for transmission of dengue, yellow fever, chikungunya, arthritis, and Zika fever. According to the World Health Organization, it is estimated that Ae. aegypti causes 50 million infections and 25,000 deaths per year. The emerging scenario highlights that the eco-friendly and effective control measures for mosquito vectors is of crucial importance. One of the most effective vector control measures has been the use of larvicidal compounds however; this success was short lived due to development of resistance against them in many mosquito strains, ecological imbalance …
Hepatīta B kora antigēna veidoto vīrusveidīgo daļiņu modificēšana vakcīnu prototipa izstrādei
2017
DENV vakcīnu izveide balstās galvenokārt, izmantojot dzīvus novājinātus vīrusus. 2015. gadā tika reģistrēta pirmā tetravalenta novājināta denges vīrusa vakcīna. Kā drošāks vakcīnas veids ir subvienību vakcīnas. Daudzsološākais DENV antigēns subvienību vakcīnas izveidē ir apvalka proteīna III domēns. Lai palielinātu antigēna subvienības imunogenitāti, tiek izmantotas vīrusveidīgās daļiņas (VLP) kā svešu antigēnu nesēji. Tā kā VLP ir pašnereplicējošas, tās tiek uzskatītas par drošākiem kandidātiem vakcīnu izveidē, salīdzinot ar dzīviem novājinātiem vīrusiem. Maģistra darba mērķis bija iegūt 2. serotipa denges vīrusa apvalka III domēnu (DV2-III) prezentējošas mutantās HBc VLP. Pētījumā tika pā…
El TRATAMIENTO PERIODÍSTICO DE LAS NOTICIAS RELACIONADAS CON LOS VIRUS DEL DENGUE Y ZIKA EN LOS MEDIOS DIGITALES DE HONDURAS (2010-2017)
2019
Resumen: En 1979, se identificó la primera epidemia de dengue en Honduras. En 2010, las autoridades sanitarias y gubernamentales hondureñas decretaron lo que sería la quinta epidemia que afectaba a la población. Cinco años más tarde, una enfermedad emergente llegó al continente americano: el zika. Las entidades internacionales como la Organización Mundial de la Salud y la Organización Panamericana de Salud extendieron la alerta a nivel latinoamericano, en especial a los países propensos por su situación geográfica, climatológica y situación socioeconómica. El objetivo del presente estudio es analizar el contenido de las noticias que se publicaron sobre los virus del dengue y zika en tres di…
Assessing the case of Dengue in Argentina 2009: discrimination and fear
2010
After almost a decade, the re-appearance of Dengue in Argentina caused panic and fears. Unlike Bolivia, Brazil and Paraguay where policies of preventions have been followed, the future of dengue is uncertain for Argentina; this paper does not have any political affiliation but emphasizes the role that mass media play in the coverage of epidemics. The question as to whether a newspaper or mass media corporation should maintain a minimum of objectivity is too complex to be resolved in this short article. However, we have so far set forth a model which will help other researchers to interpret topics of this nature in the future. In moments of disorder, uncertainty or disaster, societies experi…
Prevalence of ulcerative stomatitis in arbovirus infections in a Brazilian Northeast population
2020
Background Although there are no population-based studies that support an association, there are reports in the literature of mucocutaneous, vesiculobullous and ulcerated lesions in the oral mucosa in cases of arbovirus infection. The aim of this study is to analyze the prevalence of ulcerative stomatitis in individuals affected by arboviruses in a population of the municipality of Arcoverde, Pernambuco, Brazil. Material and Methods 1,003 people living in an area assigned to a Primary Health Care Unit were interviewed. A structured questionnaire was used for data collection, with questions about sociodemographic variables, residence conditions, general health information, as well as informa…
Avaliando o caso da dengue na Argentina em 2009: discriminação e medo
2010
Após quase uma década, a reaparição da Dengue na Argentina causou pânico e medo. Diferente da Bolívia, do Brasil e do Paraguai, onde as políticas de prevenção têm sido seguidas, o futuro da dengue fica incerto para a Argentina; este trabalho não tem qualquer afiliação política, mas destaca o papel da mídia de massa na cobertura das epidemias. A questão de se um jornal ou corporação de mídia de massa deveria manter um mínimo de objetividade é extensa demais para ser resolvida neste artigo curto. Entretanto, temos apresentado um modelo que ajudará outros pesquisadores a interpretarem temas desta natureza no futuro. Nos momentos de desordem, incerteza ou desastre, as sociedades passam por uma …
Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.
2021
The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …