Search results for "Density Functional Theory."

showing 10 items of 935 documents

Triggering dissymmetry in achiral dye molecules by chiral solvents: Circular dichroism experiments and DFT calculations

2011

The electronic circular dichroism spectra of achiral product “Lumogen F Red” (ROT-300) in four different chiral solvents are recorded at different temperatures. DFT calculations allow to identify two enantiomeric conformers for ROT-300. In vacuo they are equally populated; in chiral solvents one enantiomer prevails. Thermodynamic quantities involved in the chiral preference are derived. Chirality, 2011. © 2011 Wiley-Liss, Inc.

Models MolecularCircular dichroismMolecular ConformationPhotochemistryCatalysisAnalytical ChemistryProchiralityComputational chemistryDrug Discoverycircular dichroism (CD)time-dependent density functional theory (TDDFT)MoleculeColoring AgentsConformational isomerismSpectroscopySettore CHIM/02 - Chimica FisicaPharmacologyChemistryCircular DichroismOrganic ChemistryStereoisomerismCircular dichroism spectradye molecules solvent effectSolventsQuantum TheoryEnantiomerChirality (chemistry)Chirality
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DFT studies on the structural and vibrational properties of polyenes

2015

Detailed density functional theory (DFT) calculations on the structure and harmonic frequencies of model all-trans and all-cis polyenes were undertaken. For the first time, we report on the convergence of selected B3LYP/6-311++G** and BLYP/6-311++G** calculated structural parameters resulting from a systematic increase in polyene size (chains containing 2 to 14 C = C units). The limiting values of the structural parameters for very long chains were estimated using simple three-parameter empirical formulae. BLYP/6-311++G** calculated ν(C = C) and ν(C–C) frequencies for all-trans and all-cis polyenes containing up to 14 carbon–carbon double bonds were used to estimate these values for very lo…

Models MolecularDouble bondPolyenes02 engineering and technologyConjugated systemSpectrum Analysis RamanVibrationC-C bondAll-trans polyenesDFT01 natural sciencesMolecular physicsCatalysisInorganic ChemistryIR and Raman spectroscopychemistry.chemical_compoundComputational chemistry0103 physical sciencesWavenumberMoleculePhysical and Theoretical Chemistrychemistry.chemical_classificationOriginal Paper010304 chemical physicsChemistryOrganic ChemistryLimitingEthylenes021001 nanoscience & nanotechnologyPolyeneComputer Science ApplicationsC = C bondComputational Theory and MathematicsQuantum TheoryDensity functional theoryAll-cis polyenes0210 nano-technologyJournal of Molecular Modeling
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A computationally feasible quantum chemical model for 13C NMR chemical shifts of PCB-derived carboxylic acids.

2004

Two quantum chemical models have been derived for the prediction of 13C NMR chemical shifts of novel PCB acids obtained from PCBs by catalytic carbonylation. 13C isotropic shielding constants were calculated employing the GIAO (gauge-independent atomic orbital) method with density functional theory (DFT). The best results were obtained by cluster calculations, which took the solvent effects into account properly. In this approach, a solvent molecule (acetone) was attached by a hydrogen bond to every hydrogen atom present in a PCB acid, and the geometry of the molecular cluster was optimized employing the AM1 method. For 158 chemical shifts, the cross-validated standard error was 2.8 ppm and…

Models MolecularEnvironmental EngineeringMagnetic Resonance SpectroscopyHealth Toxicology and MutagenesisCarboxylic AcidsQuantum chemistryAtomic orbitalEnvironmental ChemistryQuantitative Biology::BiomoleculesCarbon IsotopesMolecular StructureHydrogen bondChemistryChemical shiftPublic Health Environmental and Occupational HealthGeneral MedicineGeneral ChemistryHydrogen atomCarbon-13 NMRPollutionPolychlorinated BiphenylsModels ChemicalSolventsPhysical chemistryQuantum TheoryDensity functional theoryEnvironmental PollutantsSolvent effectsSoftwareChemosphere
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Molecular orbital studies on brominated diphenyl ethers. Part I—conformational properties

2005

Polybrominated diphenyl ethers (PBDEs) are widely used as additive flame retardants and quantities in the environment are on the rise. Because they are structurally related to polychlorinated biphenyls and also to thyroid hormones, there is serious concern that PBDEs may pose a danger to human health. Knowledge of their conformational properties is key to assessing their environmental fate and risk. The conformational properties of PBDEs were investigated by quantum chemical methods including semiempirical self-consistent field molecular orbital (SCF-MO), ab initio SCF-MO and density functional theory (DFT). Conformational analyses of model congeners 2,2',4,6'-tetrabromodiphenyl ether and 2…

Models MolecularEnvironmental EngineeringStereochemistryPhenyl EthersHealth Toxicology and MutagenesisPolybrominated BiphenylsMolecular ConformationPublic Health Environmental and Occupational HealthAb initioEtherGeneral MedicineGeneral ChemistryPollutionBrominated Diphenyl EthersChemistry Techniques Analyticalchemistry.chemical_compoundPolybrominated diphenyl etherschemistryComputational chemistryAb initio quantum chemistry methodsEnvironmental ChemistryMolecular orbitalDensity functional theoryConformational isomerismFlame RetardantsChemosphere
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Stereoelectronic Requirements for Optimal Hydrogen-Bond-Catalyzed Enolization

2011

Protein crystallographic analysis of the active sites of enolizing enzymes and structural analysis of hydrogen-bonded carbonyl compounds in small molecule crystal structures, complemented by quantum chemical calculations on related model enolization reactions, suggest a new stereoelectronic model that accounts for the observed out-of-plane orientation of hydrogen-bond donors (HBDs) in the oxyanion holes of enolizing enzymes. The computational results reveal that the lone-pair directionality of HBDs characteristic for hydrogen-bonded carbonyls is reduced upon enolization, and the enolate displays almost no directional preference for hydrogen bonding. Positioning the HBDs perpendicular to the…

Models MolecularHydrogen bondOrganic ChemistryHydrogen BondingStereoisomerismOxyanionGeneral ChemistryCrystal structureKeto–enol tautomerismKetonesCarbon-Carbon Double Bond IsomerasesPhotochemistrySmall moleculeCatalysisMitochondriaCatalysischemistry.chemical_compoundCrystallographychemistryHumansThermodynamicsDensity functional theoryOxyanion holeAlgorithmsChemistry - A European Journal
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On the Catalytic Effect of Water in the Intramolecular Diels–Alder Reaction of Quinone Systems: A Theoretical Study

2012

The mechanism of the intramolecular Diels#8211;Alder (IMDA) reaction of benzoquinone 1, in the absence and in the presence of three water molecules, 1w, has been studied by means of density functional theory (DFT) methods, using the M05-2X and B3LYP functionals for exploration of the potential energy surface (PES). The energy and geometrical results obtained are complemented with a population analysis using the NBO method, and an analysis based on the global, local and group electrophilicity and nucleophilicity indices. Both implicit and explicit solvation emphasize the increase of the polarity of the reaction and the reduction of activation free energies associated with the transition stat…

Models MolecularImplicit solvationPopulationpolar Diels–Alder reactionsMolecular ConformationPharmaceutical SciencePhotochemistryArticleCatalysisAnalytical Chemistrylcsh:QD241-441lcsh:Organic chemistryComputational chemistryDrug DiscoveryDFT reactivity indicesComputer SimulationPhysical and Theoretical ChemistryeducationDiels–Alder reactioneducation.field_of_studyCycloaddition ReactionChemistryOrganic Chemistryintramolecular Diels–Alder reactionsSolvationQuinonesWaterHydrogen Bondingwater catalysisBenzoquinoneTransition stateModels ChemicalChemistry (miscellaneous)Intramolecular forceMolecular MedicineQuantum TheoryThermodynamicsDensity functional theorylocal reactivity difference indexDiterpenesAlgorithmsMolecules
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Density Functional Theory Study of the Trans-Trans-Cis (TTC)→Trans-Trans-Trans (TTT) Isomerization of a Photochromic Spiropyran Merocyanine

2008

Density Functional Theory (DFT) calculations have been performed on the TTC→TTT isomerization reaction of the open forms of the 1',3'-dihydro-8-bromo-6-nitro- 1',3',3'-trimethylspiro[2H-1-benzopyran-2,2'-(2H)indole (8-Br-6-nitro-BIPS) system. The calculations were carried out in vacuo and in methylene chloride solution at different temperatures. Results are compared with the available experimental values of free energy difference and activation energy in solution.

Models MolecularIndolesVacuumSpiropyran; photochromism; DFT calculation; solvent influence on activation energy; merocyanine.merocyaninesolvent influence on activation energyPharmaceutical ScienceDFT calculationPyrimidinonesPhotochemistryArticleAnalytical Chemistrylcsh:QD241-441Photochromismchemistry.chemical_compoundlcsh:Organic chemistryDrug DiscoveryBenzopyransMerocyaninePhysical and Theoretical ChemistryMethyleneFluorescent DyesIndole testSpiropyranMethylene ChlorideOrganic ChemistryStereoisomerismModels TheoreticalNitro CompoundsphotochromismSolutionschemistrymerocyanine.Chemistry (miscellaneous)ThermodynamicsMolecular MedicineDensity functional theorySpiropyranIsomerizationCis–trans isomerismMolecules
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What is the form of muscimol from fly agaric mushroom (Amanita muscaria) in water? An insight from NMR experiment supported by molecular modeling.

2020

ARTYKUŁ Z BADAŃ SPECJALNYCH

Models MolecularMagnetic Resonance SpectroscopyAmanita010402 general chemistry01 natural scienceschemistry.chemical_compoundReceptors GABAComputational chemistryMoleculeHumansGeneral Materials ScienceGABA-A Receptor Antagonistsindirect spin‐spin coupling constantsNMR in waterDensity Functional TheoryCarbon Isotopesbiology010405 organic chemistryAgaricmolecular modelingMuscimolChemical shiftWaterGeneral ChemistryCarbon-13 NMRbiology.organism_classification0104 chemical sciencesSolventnervous systemchemistryMuscimolGIAO NMRZwitterionProtonsAmanita muscariaMagnetic resonance in chemistry : MRCREFERENCES
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Geometric Isomerism in Pentacoordinate Cu2+ Complexes: Equilibrium, Kinetic, and Density Functional Theory Studies Reveal the Existence of Equilibriu…

2009

A ligand (L1) (bis(aminoethyl)[2-(4-quinolylmethyl)aminoethyl]amine) containing a 4-quinolylmethyl group attached to one of the terminal amino groups of tris(2-aminoethyl)amine (tren) has been prepared, and its protonation constants and stability constants for the formation of Cu(2+) complexes have been determined. Kinetic studies on the formation of Cu(2+) complexes in slightly acidic solutions and on the acid-promoted complex decomposition strongly suggest that the Cu(2+)-L1 complex exists in solution as a mixture of two species, one of them showing a trigonal bipyramidal (tbp) coordination environment with an absorption maximum at 890 nm in the electronic spectrum, and the other one bein…

Models MolecularMagnetic Resonance SpectroscopyCations DivalentMolecular ConformationProtonationLigandsInorganic ChemistryIsomerismComputational chemistryMoleculePhysical and Theoretical ChemistryMolecular StructureChemistryLigandHydrolysisNuclear magnetic resonance spectroscopyHydrogen-Ion ConcentrationSquare pyramidal molecular geometryKineticsTrigonal bipyramidal molecular geometryCrystallographySpectrophotometryDensity functional theoryProtonsAcidsCopperCis–trans isomerismInorganic Chemistry
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Effects of static and dynamic perturbations on isotropic hyperfine coupling constants in some quinone radicals.

2004

The effects of solvent dielectric response on the isotropic hyperfine coupling constants of the 1,4-benzoquinone, 1,4-naphthoquinone and 9,10-anthraquinone anions and 1,4-naphthalenediol cation radicals were studied by electron spin resonance (ESR) spectroscopy and by the theoretical density functional method within the polarizable continuum model. Experimental results demonstrate that the isotropic hyperfine coupling constants can be obtained with high accuracy and that the effects of solvent impurities can be minimized by careful sample preparation. The results obtained correlate well with theoretical predictions from density functional theory calculations. For 1,4-naphthalenediol both th…

Models MolecularMagnetic Resonance SpectroscopyFree RadicalsRadicalMolecular ConformationPolarizable continuum modelMolecular physicsSensitivity and Specificitylaw.inventionlawImpurityComputational chemistryElectric ImpedanceGeneral Materials ScienceComputer SimulationSpectroscopyElectron paramagnetic resonanceBinding SitesChemistryIsotropyQuinonesReproducibility of ResultsGeneral ChemistrySolventKineticsSolventsAnisotropyDensity functional theoryArtifactsMagnetic resonance in chemistry : MRC
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