Search results for "Derivative"

showing 10 items of 1074 documents

Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture

2016

The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from…

Dry powder inhaler (DPI)Materials scienceChemistry PharmaceuticalPharmaceutical ScienceNanotechnologyCapsulesOleic Acids02 engineering and technology030226 pharmacology & pharmacy03 medical and health sciences0302 clinical medicineHypromellose DerivativesAdministration InhalationAerodynamic diameterHPMC capsulesLubricantskin and connective tissue diseasesLubricantsFactorial modelModels StatisticalInhalationDry Powder Inhalers021001 nanoscience & nanotechnologyHypromellose DerivativesDry-powder inhalerbody regionsAerosolizationInternal lubricantLinear models0210 nano-technologyMATEMATICA APLICADABiomedical engineeringParticle fraction
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Slow Relaxation of the Magnetization in Anilato-Based Dy(III) 2D Lattices.

2021

The search for two- and three-dimensional materials with slow relaxation of the magnetization (single-ion magnets, SIM and single-molecule magnets, SMM) has become a very active area in recent years. Here we show how it is possible to prepare two-dimensional SIMs by combining Dy(III) with two different anilato-type ligands (dianions of the 3,6-disubstituted-2,5-dihydroxy-1,4-benzoquinone: C6O4X22−, with X = H and Cl) in dimethyl sulfoxide (dmso). The two compounds prepared, formulated as: [Dy2(C6O4H2)3(dmso)2(H2O)2]·2dmso·18H2O (1) and [Dy2(C6O4Cl2)3(dmso)4]·2dmso·2H2O (2) show distorted hexagonal honeycomb layers with the solvent molecules (dmso and H2O) located in the interlayer space and…

Dy(III)Models Molecularhoneycomb structureMaterials sciencePharmaceutical ScienceCrystal structureArticleAnalytical Chemistrylcsh:QD241-441chemistry.chemical_compoundMagnetizationFI-SIMlcsh:Organic chemistryCoordination ComplexesDrug DiscoveryBenzoquinonesDysprosiumMoleculePhysical and Theoretical ChemistryMolecular StructureDimethyl sulfoxideOrganic ChemistryRelaxation (NMR)SIMSMMSolventCrystallographychemistrylayered materialsChemistry (miscellaneous)MagnetMolecular MedicineDerivative (chemistry)anilato ligandsMolecules (Basel, Switzerland)
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Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

2009

Abstract Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE2 and NO production. The suvanine aldehyde derivative 4 inhibited inducible nitric oxide protein expression with an IC50 value of 7.3 μM.

EXTRACTIONmedicine.drug_classStereochemistrySesterterpenoidsBiochemistryAldehydeAnti-inflammatorySesterterpenesNitric oxidechemistry.chemical_compoundAnti-inflammatory activityEPONGESpongeDrug DiscoverymedicineOrganic chemistryIC50ACTIVITE ANTIINFLAMMATOIREchemistry.chemical_classificationTESTACTIVITE BIOLOGIQUEbiologyOrganic ChemistryINVERTEBRE AQUATIQUEbiology.organism_classificationTerpenoidSpongechemistrySUBSTANCE NATURELLEDerivative (chemistry)
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Options and Accounting Information: Empirical Evidence in Stock and Derivative Markets

2014

This study investigates the informational role of options trading in the price discovery process around the dissemination of accounting information, specifically annual and quarterly earnings announcements. Firstly, we examine the effect of options markets by analyzing stock market reaction to earnings news conditional on the availability of options markets. Secondly, we examine options-trading activity around the release of earnings news. Results show that when options trading is available, the options market enhances the price efficiency of equity markets. Moreover, the dissemination of earnings news is associated with significant unusual activity in the options market due to informed tra…

Earnings response coefficientEarningsFinancial economicsAccounting information systemDerivatives marketNon-qualified stock optionStock marketBusinessEarnings surprisePrice discoverySSRN Electronic Journal
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Credit derivatives disclosure in banks’ risk reporting: Empirical evidence from four large European banks

2019

This paper aims to analyze the derivatives disclosure in banks’ annual risk reports. In this paper, the author uses content analysis to examine the qualitative and quantitative profiles of the derivatives disclosure at a cross-country level, with particular reference to credit derivatives. The empirical research is conducted on a sample of large European banks. The paper also shows that there is room to improve various aspects of derivatives disclosure, and provides some useful insights for further research. The derivatives disclosure in banks’ annual risk reports has deep managerial, financial, regulatory and accounting implications at a firm and industry levels, and the comprehension of t…

Economics and Econometrics050208 financeSettore SECS-P/11 - Economia Degli Intermediari Finanziaribusiness.industryStrategy and Management05 social sciencesAccountingSample (statistics)050201 accountingEmpirical researchRisk reporting Risk disclosure Credit derivative Banking Financial regulation Risk management Banking risks.Content analysis0502 economics and businessCredit derivativebusinessEmpirical evidenceFinanceRisk Governance and Control: Financial Markets and Institutions
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Rolling over stock index futures contracts

2009

Derivative contracts have a finite life limited by their maturity. The construction of continuous series, however, is crucial for academic and trading purposes. In this study, we analyze the relevance of the choice of the rollover date, defined as the point in time when we switch from the front contract series to the next one. We have used five different methodologies in order to construct five different return series of stock index futures contracts. The results show that, regardless of the criterion applied, there are not significant differences between the resultant series. Therefore, the least complex method can be used in order to reach the same conclusions. © 2009 Wiley Periodicals, I…

Economics and EconometricsActuarial scienceSeries (mathematics)Rollover (finance)Discount pointsGeneral Business Management and AccountingMaturity (finance)Derivative (finance)Order (exchange)AccountingEconomicsRelevance (information retrieval)Futures contractFinanceJournal of Futures Markets
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The timeline of trading frictions in the European carbon market

2012

We evaluate the quality of prices of EU-ETS, the most active European derivative market for greenhouse gas emissions allowances (EUAs). So far, this market has had two phases, a trial phase (from 2005 to 2007) and a commitment phase (from 2008 to 2012). The true value of a trial-phase EUA at the beginning of 2008 was inevitably zero because it could not be used in the commitment phase to cover emission targets. However, continued rumors of over-allocation of EUAs led to an early collapse of the market by May 2007. We study whether this market breakdown and the subsequent outbreak of the international financial crisis had a persistent effect on the quality of the commitment phase. We provide…

Economics and EconometricsAdverse selectionTimelineMarket microstructureMonetary economicsEuropean Union Emission Trading SchemeTrial Phasecomputer.software_genreMarket makerMarket liquidityMicroeconomicsGeneral EnergyGreenhouse gasFinancial crisisDerivatives marketEconomicsPrice returnEmissions tradingVolatility (finance)Algorithmic tradingcomputerEnergy Economics
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Model Based Monte Carlo Pricing of Energy and Temperature Quanto Options

2010

Weather derivatives have become very popular tools in weather risk management in recent years. One of the elements supporting their diffusion has been the increase in volatility observed on many energy markets. Among the several available contracts, Quanto options are now becoming very popular for a simple reason: they take into account the strong correlation between energy consumption and certain weather conditions, so enabling price and weather risk to be controlled at the same time. These products are more efficient and, in many cases, significantly cheaper than simpler plain vanilla options. Unfortunately, the specific features of energy and weather time series do not enable the use of …

Economics and EconometricsComputer scienceMonte Carlo methodTemperature levelBivariate analysisEnergy priceDynamic modelMicroeconomicsEconomicsEconometricsweather derivatives Quanto options pricing derivative pricing model simulation and forecast.Time seriesQuanto options; Temperature level; Energy price; Dynamic modelMonte Carlo methods for option pricingjel:C53Quanto optionsjel:C51Energy consumptionVariance (accounting)jel:C32Quantojel:G13weather derivatives; Quanto options pricing; derivative pricing; model simulation; forecastjel:L94jel:G17General Energyjel:Q54Binomial options pricing modelVolatility (finance)Futures contract
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A critical view on temperature modelling for application in weather derivatives markets

2012

In this paper we present a stochastic model for daily average temperature. The model contains seasonality, a low-order autoregressive component and a variance describing the heteroskedastic residuals. The model is estimated on daily average temperature records from Stockholm (Sweden). By comparing the proposed model with the popular model of Campbell and Diebold (2005), we point out some important issues to be addressed when modelling the temperature for application in weather derivatives market.

Economics and EconometricsHeteroscedasticityStochastic modellingAutoregressive conditional heteroskedasticityVariance (accounting)Seasonalitymedicine.diseaseGeneral EnergyAutoregressive modelDerivatives marketmedicineEconometricsTime seriesMathematicsEnergy Economics
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Temperature and seasonality influences on Spanish electricity load

2002

Abstract Deregulation of the Spanish electricity market in 1998 and the possible listing of electricity or weather derivative contracts have encouraged the study of the relationship between electricity demand and weather in Spain. In this paper, a transfer function intervention model is developed for forecasting daily electricity load from cooling and heating degree–days. The influence of weather and seasonality is proved, and is significant even when the autoregressive effects and the dynamic specification of the temperature are taken into account. The estimated general model shows a high predictive power. The results and information presented in this paper could be of interest for current…

Economics and Econometricsbusiness.industryWeather derivativeDeregulationGeneral EnergyAutoregressive modelEconometricsEconomicsPredictive powerElectricity marketElectricityListing (finance)businessEnergy economicsEnergy Economics
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