Search results for "Dermatitis"
showing 10 items of 220 documents
Skimager for the objective erythema estimation in atopic dogs
2020
In this study, the severity of canine skin erythema was assessed objectively for the first time. Atopic dermatitis (AD) is a common canine inflammatory and pruritic skin disease associated with an allergic reaction to exogenous allergens. The monitoring of skin erythema over time with lesion severity scales like the CADESI-4 is an essential diagnostic and research tool, especially for clinical trials. Currently, the erythema assessment is subjective due to visual estimation. In our study, we calculated the erythema index (EI) in 14 atopic dogs based on the analysis of multispectral skin images taken with the Skimager device. The relationship between the EI and a visual erythema estimation w…
Cutaneous Exposure to the Superantigen Staphylococcal Enterotoxin B Elicits a T-Cell-Dependent Inflammatory Response
1996
We analyzed the impact of superantigens secreted by skin-colonizing Staphylococci on the skin and the associated lymphoid tissue following epicutaneous application and intracutaneous injection of small amounts of staphylococcal enterotoxin B (SEB). A single intracutaneous injection of 50 ng of SEB elicited a strong inflammatory response in the skin of BALB/c mice. Three to 6 h later, we observed langerhans cell activation, mast cell degranulation, vasodilation, upregulation of ICAM-1, and induction of VCAM-1 on dermal blood vessels, with vascular adhesion of granulocytes. by 12 to 24 h, cell infiltration of the dermis increased, reaching the epidermis. Among the infiltrating leukocytes, a s…
Antibodies directed to drug epitopes to investigate the structure of drug-protein photoadducts. Recognition of a common photobound substructure in ti…
2001
Drug-induced photoallergy is an immune adverse reaction to the combined effect of drugs and light. From the mechanistic point of view, it first involves covalent binding of drug to protein resulting in the formation of a photoantigen. Hence, determination of the structures of drug-protein photoadducts is of great relevance to understand the molecular basis of photoallergy and cross-immunoreactivity among drugs. Looking for new strategies to investigate the covalent photobinding of drugs to proteins, we generated highly specific antibodies to drug chemical substructures. The availability of such antibodies has allowed us to discriminate between the different modes by which tiaprofenic acid (…
Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene
2005
Sesquiterpene acids are natural products that, in contrast with the thoroughly studied sesquiterpene lactones, have received little pharmacological attention. A good source of this class of compounds is Inula viscosa (Asteraceae), a plant with documented anti-inflammatory effects. The present paper gives the results of our investigations on the biochemical mechanisms involved in the anti-inflammatory activity of one such compound, dehydrocostic acid. The most salient findings were that in vitro dehydrocostic acid inhibits leukotriene B(4) production (IC(50)=22 microM), elastase activity (IC(50)=43 microM) and bee venom phospholipase A(2) activity (IC(50)=17 microM). Furthermore, this sesqui…
Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis
2021
Simple Summary Atopic dermatitis, also called neurodermatitis, is one of the best-known chronic inflammatory skin diseases with eczema, strong itch and dry skin. It is based on an impaired skin barrier with changes in the fats and proteins of the horny layer, which leads to a disturbed water balance. Prurigo nodularis is a less common and intractable chronic skin disease with very itchy nodules. It can be associated with atopic dermatitis (so called atopic prurigo) or with many other diseases. The aim of this study was to compare these three skin diseases classic atopic dermatitis, atopic prurigo and non-atopic prurigo nodularis with healthy control subjects with regard to their skin barrie…
Adipokines as Biomarkers of Atopic Dermatitis in Adults
2020
Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult non-obese patients suffering from chronic extrinsic childhood-onset AD. We investigated 49 AD patients with a median age of 37 years. The control group consisted of 30 age-matched healthy subjects. Adipokines were assessed in the serum by ELISA assays and the severity of AD with the SCORing Atopic Dermatitis (SCORAD) index. We found that adiponectin and resistin decreased and l…
Dermatitis alérgica de contacto a cosméticos, estudio prospectivo durante los años 2005-2013 y estudio comparativo con el perido previo de 1996-2004
2015
INTRODUCCIÓN: En la sociedad actual, el culto a la belleza ha adquirido su máxima expresión, considerándose ésta sinónimo de éxito y de felicidad. Los cosméticos constituyen uno de los productos más importantes del mercado de la belleza, y su crecimiento es imparable. Por lo general son seguros y bien tolerados, y se encuentran sometidos a una legislación específica a nivel nacional y europeo con el objetivo de garantizar la ausencia de riesgos para la salud. Sin embargo, cada vez son más numerosos los estudios que describen reacciones adversas cutáneas relacionadas con el uso de cosméticos. De hecho, aunque la prevalencia de la dermatitis alérgica de contacto (DAC) a cosméticos se ha situa…
Comparing tacrolimus ointment and oral cyclosporine in adult patients affected by atopic dermatitis: a randomized study
2004
BACKGROUND: Atopic dermatitis (AD) is a chronic allergic inflammatory disease, which manifests itself with eczematous skin lesions. OBJECTIVE: We compared the clinical efficacy of tacrolimus ointment (0.1%) given twice a day and oral cyclosporine (3 mg/kg) given once daily. Rescue medication for itching included cetirizine 10-20 mg (equal to one or two tables). METHODS: Thirty patients, aged 13-45 years (mean+/-SD 27.1+/-10.9), with a history of moderate-to-severe AD were randomized to treatments, 15 patients for each treatments. Assessment of efficacy was based on SCORAD, on scores of daily itching, erythema, interference with sleep, due to the skin condition and days without use of cetiri…
Probiotics in the prevention and treatment of atopic dermatitis
2020
The use of probiotic supplements might change the composition of the intestinal flora of children, subsequently modulating the immune system's reactivity. The effects of probiotic administration for the prevention/treatment of allergic diseases and atopic dermatitis, in particular, are still so controversial that no definitive recommendation can be made at this stage. Differences in strain specificity, timing, and length of administration all contribute to diversifying the conclusions of this review.
Probiotiku izvēle atopiskā dermatīta gadījumos
2018
Alerģijas epidēmijas veicināšanā lielu lomu spēlē mūsdienu attīstītās sabiedrības dzīvesveids, kuru raksturo mikrobiālas floras nomākšana, tā izmainot cilvēka mikrobiotu un negatīvi ietekmējot imūno regulāciju (Fiocchi et al 2015). Maģistra darba mērķis bija noskaidrot dermatologu viedokli par atopisko dermatītu, ņemot vērā ārstēšanas vadlīnijas, un, izanalizējot zinātniskās publikācijas, izpētīt atopiskā dermatīta ārstēšanas tendences Latvijā, un izpētīt probiotiķu lomu atopiskā dermatīta profilaksē. Anketas aizpildīja ārsti – dermatologi (praktizējošie ārsti). Datu analīzei tika izmantotas 70 aptaujas. Secinājumi: Atopiskā dermatīta ārstēšanā visbiežāk izvēlas topiski lietojamos glokokort…