Search results for "Dermatopathology"

showing 5 items of 5 documents

The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA.

2019

AIMS The risk assessment of spitzoid lesions is one of the most difficult challenges in dermatopathology practice. In this regard, the loss of p16 expression and the homozygous deletion of CDKN2A, have been pointed in the literature as reliable indicators of high risk. However, these findings are poorly reproducible, and the molecular bases underlying the loss of p16 expression remain unclear. We aimed to identify the underlying events causing loss of CDKN2A/p16 in spitzoid tumors. MATERIALS AND METHODS We evaluated the immunohistochemical expression of p16, and the presence of CDKN2A genetic alterations detected through fluorescence in situ hybridization (FISH) and multiplex ligation-depen…

0301 basic medicineAdultMalePathologymedicine.medical_specialtyHistologySkin NeoplasmsPathology and Forensic MedicineMelanin03 medical and health sciencesYoung Adult0302 clinical medicineCDKN2ANevus Epithelioid and Spindle CellmedicineBiomarkers TumorNevusHumansMultiplex ligation-dependent probe amplificationneoplasmsMelanomaCyclin-Dependent Kinase Inhibitor p16In Situ Hybridization FluorescenceMelaninsmedicine.diagnostic_testbusiness.industryMelanomamedicine.diseaseImmunohistochemistryGene Expression Regulation NeoplasticMedical Laboratory Technology030104 developmental biology030220 oncology & carcinogenesisMutationImmunohistochemistryMelanocytesFemaleDermatopathologybusinessMultiplex Polymerase Chain ReactionFluorescence in situ hybridizationApplied immunohistochemistrymolecular morphology : AIMM
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Granulomas en dermatopatología: principales entidades. Parte I

2021

This series of 2 articles on dermatopathologic diagnoses reviews conditions in which granulomas form. Part 1 clarifies concepts, discusses the presentation of different types of granulomas and giant cells, and considers a large variety of noninfectious diseases. Some granulomatous diseases have a metabolic origin, as in necrobiosis lipoidica. Others, such as granulomatous mycosis fungoides, are related to lymphomas. Still others, such as rosacea, are so common that dermatologists see them nearly daily in clinical practice.

medicine.medical_specialtybusiness.industryLanghans giant cellGeneral Medicinemedicine.diseaseDermatologyNecrobiosis lipoidicaClinical PracticeGiant cellRosaceaTouton giant cellhemic and lymphatic diseasesGranulomaMedicineDermatopathologybusinessActas Dermo-Sifiliográficas
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Granulomas en dermatopatología: principales entidades. Parte II

2021

Part 2 of this series on granulomatous diseases focuses on skin biopsy findings. Whereas the first part treated noninfectious conditions (metabolic disorders and tumors, among other conditions), this part mainly deals with various types of infectious disease along with other conditions seen fairly often by clinical dermatologists.

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryFairly OftenLanghans giant cellGeneral Medicinemedicine.diseaseDermatologyGiant cellTouton giant cellInfectious disease (medical specialty)GranulomaSkin biopsyMedicineDermatopathologybusinessActas Dermo-Sifiliográficas
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Papulo-purpuric dermatitis of childhood: a distinct PLEVA-like eruption associated to SARS-CoV-2 infection. Clinical, histopathological and immunohis…

2021

Abstract We observed ten children with a papular eruption with purpuric features during the SARS‐CoV‐2 pandemic in Northern Italy (May‐December 2020). Histological examination showed signs of SARS‐CoV‐2‐related dermatosis. Evidence of nucleocapsid viral proteins using SARS‐CoV‐2 (2019‐nCoV) nucleocapsid antibody revealed cuticular staining of the deep portion of the eccrine glands in all cases.

Pathologymedicine.medical_specialtySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)virusesdermatopathology pediatric PLEVA SARS-CoV-2 skin histopathology Humans Pandemics SARS-CoV-2 COVID-19 Dermatitis PurpuraDermatitisDermatologySARS‐CoV‐2Eccrine glandMedicineHumansskin and connective tissue diseasesdermatopathologyPandemicsPurpuraHistological examinationbiologybusiness.industrySARS-CoV-2fungiskin histopathologyCOVID-19Original ArticlesNorthern italyStainingrespiratory tract diseasesbody regionspediatricPLEVAPediatrics Perinatology and Child Healthbiology.proteinImmunohistochemistryOriginal ArticleDermatopathologyAntibodybusiness
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Depressed indurated plaque with elastorrhexis as a distinctive lesion in Buschke‐Ollendorff syndrome

2020

Buschke-Ollendorff syndrome (BOS) is a rare autosomal dominant genodermatosis caused by heterozygous mutations in LEMD3 and characterized by connective tissue nevi and sclerotic bone lesions known as osteopoikilosis. We report a family with three individuals affected by BOS, two of whom manifested clinical and histopathological peculiarities, presenting with a depressed indurated plaque as the main cutaneous manifestation instead of the classic connective tissue nevi. Notable elastorrhexis was present in both biopsies.

AdultMalePathologymedicine.medical_specialtyDermatologySkin DiseasesLesionBuschke–Ollendorff syndrome030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinemedicineHumansChildSclerotic boneOsteopoikilosisConnective tissue nevusbusiness.industryGenodermatosisSkin Diseases Geneticmedicine.diseasehumanities030220 oncology & carcinogenesisPediatrics Perinatology and Child HealthFemaleOsteopoikilosisDermatopathologymedicine.symptombusinessPediatric Dermatology
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