Search results for "Design"

Time and the Design of Web-Based Learning Environments

2005

Introduction Design can be seen as a form of creation, which involves complexity and synthesis (Goel & Pirolli, 1992; Schon, 1987). In a broad sense, anyone who designs is a designer. This means that unlike analysts or critics, designers put elements together and bring new creations into being. In so doing they deal with many variables and constraints, some initially known and some discovered through the design process (Etelapelto, 1998). According to Burgoon, Buller, and Woodall (1996), it is typically human to affect and change one's environment. However humans are affected by their physical surroundings as well. Schon (1987) perceives all human constructive and creative activity as desig…

User-oriented evaluation of mechanical single-channel axial pipettes.

2013

Hand tools should be designed so that they are comfortable to use, fit the hand and are user-oriented. Six different manual, single-channel axial pipettes were evaluated for such objective outcomes as muscular activity, wrist postures and efficiency, as well as for subjective outcomes concerning self-assessed features of pipette usability and musculoskeletal strain. Ten experienced laboratory employees volunteered for the study. The results showed that light and short pipettes with better tool comfort resulted in reduced muscular activity and perceived musculoskeletal strain when they were compared with a long and heavy pipette. There were no differences in the efficiency between the differ…

Modeling hexanal production in oxido-reducing conditions by the yeast Yarrowia lipolytica

2009

International audience; Hexanal produced by cells of a recombinant Yarrowia lipolytica yeast expressing the hydroperoxide lyase (HPL) from green bell pepper fruit was studied under oxido-reducing conditions using the reducing dithiotreitol and oxidizing potassium ferricyanide compounds. The combined effect of pH, linoleic acid 13-hydroperoxides concentration, temperature and oxido-reducing molecules on the hexanal production was studied. Significant positive effects for the hexanal production were found using high concentrations of hydroperoxides (100 mM, 30 g/L). Adding reducing molecules enhanced significantly hexanal production while the oxidizing molecules had an inhibitory effect. Comb…

Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia.

2016

Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especial…

Using/Designing Digital Technologies of Representation in Aborginal Australian Knowledge Practices

2007

Palladium coupling catalysts for pharmaceutical applications

2007

International audience; This review discusses recent advances made in the area of palladium-catalyzed coupling reactions and describes a selection of the catalytic systems that are useful in the preparation of valuable compounds for the pharmaceutical industry. Most of these types of syntheses have used either simple palladium salts or palladium precursors associated with electron-rich mono- or bidentate phosphine ligands as catalysts. For some reactions, ligands such as triphenyl phosphine, 1,1'-bis(diphenylphosphino)ferrocene, a carbene or a bipyridine have also been employed. Several new procedures for the Suzuki cross-coupling reaction, the activation of aryl chlorides, the functionaliz…

Overlapping community detection versus ground-truth in AMAZON co-purchasing network

2015

International audience; Objective evaluation of community detection algorithms is a strategic issue. Indeed, we need to verify that the communities identified are actually the good ones. Moreover, it is necessary to compare results between two distinct algorithms to determine which is most effective. Classically, validations rely on clustering comparison measures or on quality metrics. Although, various traditional performance measures are used extensively. It appears very clearly that they cannot distinguish community structures with different topological properties. It is therefore necessary to propose an alternative methodology more sensitive to the community structure variations in orde…

Extending CSG with projections: Towards formally certified geometric modeling

2015

We extend traditional Constructive Solid Geometry (CSG) trees to support the projection operator. Existing algorithms in the literature prove various topological properties of CSG sets. Our extension readily allows these algorithms to work on a greater variety of sets, in particular parametric sets, which are extensively used in CAD/CAM systems. Constructive Solid Geometry allows for algebraic representation which makes it easy for certification tools to apply. A geometric primitive may be defined in terms of a characteristic function, which can be seen as the zero-set of a corresponding system along with inequality constraints. To handle projections, we exploit the Disjunctive Normal Form,…

Extensions of the witness method to characterize under-, over- and well-constrained geometric constraint systems

2011

International audience; This paper describes new ways to tackle several important problems encountered in geometric constraint solving, in the context of CAD, and which are linked to the handling of under- and over-constrained systems. It presents a powerful decomposition algorithm of such systems. Our methods are based on the witness principle whose theoretical background is recalled in a first step. A method to generate a witness is then explained. We show that having a witness can be used to incrementally detect over-constrainedness and thus to compute a well-constrained boundary system. An algorithm is introduced to check if anchoring a given subset of the coordinates brings the number …

Semantic oriented data structuration for MABS Application to BIM

2013

International audience; This paper presents a multiagent-based simulation approach to qualify the usage of buildings from the design phase. Our approach combines ontology and evolution process based on machine learning algorithms. The ontology relies on semantic data structures for the representation of environment components, agent knowledge and all data generated during the simulation.