Search results for "Development"

Author response: Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

2017

Analysis of Activity States of Local Neuronal Microcircuits in Mouse Brain

2018

Time series of neuronal activity corresponding to different activity states in mouse brain are analyzed in the time domain and the time-frequency domain. The signals are associated with either a slow wave brain state or a persistent brain state. For both states, characteristic spectral features are identified and a simple detector is proposed that is able to identify the brain state with low latency and high accuracy. In practice, being able to monitor the brain state online and in real time is crucial for improved in vivoexperiments and, ultimately, for a causal understanding of brain dynamics.

A Fast Multiresolution Approach Useful for Retinal Image Segmentation

2018

Retinal diseases such as retinopathy of prematurity (ROP), diabetic and hypertensive retinopathy present several deformities of fundus oculi which can be analyzed both during screening and monitoring such as the increase of tortuosity, lesions of tissues, exudates and hemorrhages. In particular, one of the first morphological changes of vessel structures is the increase of tortuosity. The aim of this work is the enhancement and the detection of the principal characteristics in retinal image by exploiting a non-supervised and automated methodology. With respect to the well-known image analysis through Gabor or Gaussian filters, our approach uses a filter bank that resembles the “à trous” wav…

Combining GPU and FPGA technology for efficient exhaustive interaction analysis in GWAS

2016

Interaction between genes has become a major topic in quantitative genetics. It is believed that these interactions play a significant role in genetic variations causing complex diseases. Due to the number of tests required for an exhaustive search in genome-wide association studies (GWAS), a large amount of computational power is required. In this paper, we present a hybrid architecture consisting of tightly interconnected CPUs, GPUs and FPGAs and a fine-tuned software suite to outperform other implementations in pairwise interaction analysis while consuming less than 300Watts and fitting into a standard desktop computer case.

Detection of Southern tomato virus by molecular hybridisation

2017

A nuclear Xdh phylogenetic analysis of yams (Dioscorea: Dioscoreaceae) congruent with plastid trees reveals a new Neotropical lineage

2018

Weighted fitness theory: an approach to symbiotic communities

2017

Zur Bedeutsamkeit von Operationalisierungen medienpädagogischer Grundbegriffe: Kritisch-rationale Anmerkungen zur Medienbildung

2017

Der hier dargestellte Entwurf einer kritisch-rationalen Medienbildung basiert auf dem Entwurf einer kritisch-rationalen Medienpädagogik. Die Medienpädagogik im Allgemeinen und die Medienbildung im Speziellen müssen sich in der Bestimmung ihrer Grundbegriffe auf allgemeinpädagogische Arbeiten rückbeziehen und sollten nicht versuchen, ihre Grundbegriffe komplett neu zu definieren. Dies wird in diesem Beitrag exemplarisch für die Grundbegriffe Erziehung, Sozialisation und Bildung getan. Der Bildungsbegriff wird ausführlicher behandelt und es wird dafür plädiert, zwischen einer Medienausbildung und Medienselbstbildung zu unterscheiden. Beide Aspekte sind gleichermassen relevant für die Medienbi…

Identificación de polimorfismos de nucleótido simple en centenarios

2016

Resumen Introduccion La longevidad viene determinada por la genetica propia de cada especie y por factores externos, tales como nutricionales, ambientales, sociales, etc. Sin embargo, los individuos mas longevos se caracterizan por presentar una mayor adaptacion al entorno condicionada predominantemente por su propia genetica. Dentro de una misma poblacion con relativa homogeneidad genotipica, podemos encontrar cambios sutiles en la secuencia de ADN que afectan unicamente a un nucleotido. Estos cambios denominados polimorfismos de nucleotido simple ( Single Nucleotide Polimorphisim [SNP]) se encuentran con una prevalencia mayor al 1-5% de la poblacion. Por ello, nos planteamos estudiar en i…

Identificación de polimorfismos de un solo nucleótido relacionados con la fragilidad

2018

Resumen Introduccion La busqueda de biomarcadores que permitan la deteccion y el posible tratamiento precoz de la fragilidad se ha convertido en uno de los objetivos primordiales de la comunidad cientifica geriatrica. El objetivo del presente estudio fue identificar polimorfismos de un solo nucleotido ([SNP] del ingles single nucleotide polymorphisms) relacionados con la fragilidad. Material y metodos El estudio se llevo a cabo en 152 sujetos de la cohorte del Estudio de Toledo (de 65 a 95 anos de edad), clasificados como fragiles (n = 78), y no fragiles (n = 74), segun los criterios de Fried. Tras la extraccion de sangre se aislo y amplifico el ADN para el analisis de SNP mediante la tecno…